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The Bidirectional Role of Cellular Senescence in the Treatment of Ovarian Cancer. [PDF]
BiomedicinesYuan D +7 more
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The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP)
Experimental Cell Research, 2020Cellular senescence is a phenomenon of irreversible growth arrest of mammalian somatic cells. Senescent cells increase the production of secretory proteins such as inflammatory cytokines, a phenomenon termed senescence-associated secretory phenotype (SASP).
Michihiko Fujii
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Toxicology and Applied Pharmacology, 2022
Exposure to inorganic arsenic has been known to induce cancers in various organs, however, the underlying mechanisms remain unclear. Premature senescence refers to the irreversible growth arrest induced by stress stimuli. The senescence-associated secretory phenotype (SASP), particularly in fibroblasts, has been shown to promote cancer development.
Kieko Nohara, Kazuyuki Okamura
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Exposure to inorganic arsenic has been known to induce cancers in various organs, however, the underlying mechanisms remain unclear. Premature senescence refers to the irreversible growth arrest induced by stress stimuli. The senescence-associated secretory phenotype (SASP), particularly in fibroblasts, has been shown to promote cancer development.
Kieko Nohara, Kazuyuki Okamura
exaly +3 more sources
Journal of Investigative Dermatology, 2021
During aging, skin accumulates senescent cells. The transient presence of senescent cells, followed by their clearance by the immune system, is important in tissue repair and homeostasis. The persistence of senescent cells that evade clearance contributes to the age-related deterioration of the skin.
Johannes Grillari +2 more
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During aging, skin accumulates senescent cells. The transient presence of senescent cells, followed by their clearance by the immune system, is important in tissue repair and homeostasis. The persistence of senescent cells that evade clearance contributes to the age-related deterioration of the skin.
Johannes Grillari +2 more
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Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)
2018Cellular senescence is linked to many normal biological processes, including tumor suppression, development, and wound healing, but it is also associated with age-related pathologies such as cancer progression. Numerous functions of senescent cells depend on their ability to secrete bioactive molecules, a characteristic termed the senescence-associated
Nicolas, Malaquin +2 more
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Detecting the Senescence-Associated Secretory Phenotype (SASP) by High Content Microscopy Analysis
2016The diverse arrays of proteins secreted by senescent cells have been described to influence aging and to have both pro-tumorigenic and anti-tumorigenic influences on the surrounding microenvironment. Further characterization of these proteins, known as the senescence-associated secretory phenotype (SASP), and their regulators is required to understand ...
Priya, Hari, Juan Carlos, Acosta
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Detection of the Senescence-Associated Secretory Phenotype (SASP)
2012Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
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Genes & Cells, 2014
To study the cellular senescence mechanisms and senescence-associated secretory phenotype of the tumor cell lines in response to doxorubicin exposure. The cell lines indicated above were used in present study: human fibroblasts lines BJ, human osteosarcoma cell line U-2 OS and gastrointestinal stromal tumor cell line GIST-T1.
B. R Ramazanov +2 more
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To study the cellular senescence mechanisms and senescence-associated secretory phenotype of the tumor cell lines in response to doxorubicin exposure. The cell lines indicated above were used in present study: human fibroblasts lines BJ, human osteosarcoma cell line U-2 OS and gastrointestinal stromal tumor cell line GIST-T1.
B. R Ramazanov +2 more
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