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Circulation, 2022
Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We aimed to assess the prognostic significance of the SASP assessed by a combination of plasma protein biomarkers in human HF. Methods:
Chenao Qian +12 more
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Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We aimed to assess the prognostic significance of the SASP assessed by a combination of plasma protein biomarkers in human HF. Methods:
Chenao Qian +12 more
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Detection of the Senescence-Associated Secretory Phenotype (SASP)
2012Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
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2022
ABSTRACTCellular senescence, irreversible cell cycle arrest, is induced by various triggers including telomere shortening, oncogene activation, and DNA damage. Senescent cells exhibit the senescence-associated secretory phenotype (SASP), a pathological feature that contributes to organismal aging.
Nurhanani Razali +4 more
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ABSTRACTCellular senescence, irreversible cell cycle arrest, is induced by various triggers including telomere shortening, oncogene activation, and DNA damage. Senescent cells exhibit the senescence-associated secretory phenotype (SASP), a pathological feature that contributes to organismal aging.
Nurhanani Razali +4 more
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Molecular Cancer Research, 2019
Abstract Dyskeratosis congenita is a telomere DNA damage syndrome characterized by defective telomere maintenance, bone marrow failure, and increased head and neck cancer risk. The Pot1b−/−;Terc+/− mouse exhibits some features of dyskeratosis congenita, but head and neck cancer was not ...
Angelica M, Lagunas +5 more
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Abstract Dyskeratosis congenita is a telomere DNA damage syndrome characterized by defective telomere maintenance, bone marrow failure, and increased head and neck cancer risk. The Pot1b−/−;Terc+/− mouse exhibits some features of dyskeratosis congenita, but head and neck cancer was not ...
Angelica M, Lagunas +5 more
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Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP)
Dual-faced cellular senescence is responsible for beneficial biological processes and for age-related pathologies. Senescent cells under stable proliferation arrest develop numerous senescence-associated phenotypes such as the potent pro-inflammatory secretome called the senescence-associated secretory phenotype (SASP).Nicolas, Malaquin, Francis, Rodier
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Free Radical Biology and Medicine, 2015
Cellular senescence has evolved as one of the protective mechanisms to arrest the growth of cells with oncogenic potential. While senescent cells lose the ability to divide, they remain metabolically active and adapt a senescence-associated secretory phenotype (SASP).
Akshaya Chandrasekaran +3 more
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Cellular senescence has evolved as one of the protective mechanisms to arrest the growth of cells with oncogenic potential. While senescent cells lose the ability to divide, they remain metabolically active and adapt a senescence-associated secretory phenotype (SASP).
Akshaya Chandrasekaran +3 more
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Archives of Pharmacal Research, 2017
During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin.
Hyun Lim +4 more
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During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin.
Hyun Lim +4 more
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Cancer Research
Abstract Cellular senescence is a stress-induced program following aberrant oncogene activation or administration of cancer therapies, including chemotherapeutic agents and CDK4/6 inhibitors commonly used for treating advanced breast cancers, that results in the proliferative arrest of damaged cells and induction of the senescence ...
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Abstract Cellular senescence is a stress-induced program following aberrant oncogene activation or administration of cancer therapies, including chemotherapeutic agents and CDK4/6 inhibitors commonly used for treating advanced breast cancers, that results in the proliferative arrest of damaged cells and induction of the senescence ...
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Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
2021Fabiola Olivieri +2 more
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Apoptotic stress causes mtDNA release during senescence and drives the SASP
Nature, 2023Stella Victorelli +2 more
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