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Inflammopharmacology
Cellular senescence is a natural process, where cells permanently stop dividing in response to stress, helping prevent cancer and assist in tissue repair. However, these senescent cells release a variety of inflammatory factors, known as the senescence-associated secretory phenotype (SASP), which, when persistent, can cause chronic inflammation ...
Poonam Sahu, Trilochan Satapathy
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Cellular senescence is a natural process, where cells permanently stop dividing in response to stress, helping prevent cancer and assist in tissue repair. However, these senescent cells release a variety of inflammatory factors, known as the senescence-associated secretory phenotype (SASP), which, when persistent, can cause chronic inflammation ...
Poonam Sahu, Trilochan Satapathy
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2022
ABSTRACT Cellular senescence, irreversible cell cycle arrest, is induced by various triggers including telomere shortening, oncogene activation, and DNA damage. Senescent cells exhibit the senescence-associated secretory phenotype (SASP), a pathological feature that contributes to organismal aging.
Nurhanani Razali +4 more
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ABSTRACT Cellular senescence, irreversible cell cycle arrest, is induced by various triggers including telomere shortening, oncogene activation, and DNA damage. Senescent cells exhibit the senescence-associated secretory phenotype (SASP), a pathological feature that contributes to organismal aging.
Nurhanani Razali +4 more
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Natural Products as Anti-Senescence-Associated Secretory Phenotype (SASP) Agents
Current Medicinal ChemistryCellular senescence denotes an irreversible cell-cycle arrest implicated in or-ganismal aging and age-related disorders, distinguished by the Senescence-Associated Secretory Phenotype (SASP). SASP manifests the capacity of senescent cells to secrete a broad array of bioactive molecules-cytokines, chemokines ...
Lina Yang +4 more
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Free Radical Biology and Medicine, 2015
Cellular senescence has evolved as one of the protective mechanisms to arrest the growth of cells with oncogenic potential. While senescent cells lose the ability to divide, they remain metabolically active and adapt a senescence-associated secretory phenotype (SASP).
Akshaya Chandrasekaran +3 more
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Cellular senescence has evolved as one of the protective mechanisms to arrest the growth of cells with oncogenic potential. While senescent cells lose the ability to divide, they remain metabolically active and adapt a senescence-associated secretory phenotype (SASP).
Akshaya Chandrasekaran +3 more
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Cancer Research
Abstract Cellular senescence is a stress-induced program following aberrant oncogene activation or administration of cancer therapies, including chemotherapeutic agents and CDK4/6 inhibitors commonly used for treating advanced breast cancers, that results in the proliferative arrest of damaged cells and induction of the senescence ...
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Abstract Cellular senescence is a stress-induced program following aberrant oncogene activation or administration of cancer therapies, including chemotherapeutic agents and CDK4/6 inhibitors commonly used for treating advanced breast cancers, that results in the proliferative arrest of damaged cells and induction of the senescence ...
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Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
2021Fabiola Olivieri +2 more
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Alleviating effects of plant extracts on senescence associated secretory phenotype (SASP)
Masterarbeit Wien, FH Campus Wien ...openaire +1 more source