Results 231 to 240 of about 8,456,945 (252)
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Molecular Cancer Research, 2019
Abstract Dyskeratosis congenita is a telomere DNA damage syndrome characterized by defective telomere maintenance, bone marrow failure, and increased head and neck cancer risk. The Pot1b−/−;Terc+/− mouse exhibits some features of dyskeratosis congenita, but head and neck cancer was not ...
Angelica M, Lagunas +5 more
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Abstract Dyskeratosis congenita is a telomere DNA damage syndrome characterized by defective telomere maintenance, bone marrow failure, and increased head and neck cancer risk. The Pot1b−/−;Terc+/− mouse exhibits some features of dyskeratosis congenita, but head and neck cancer was not ...
Angelica M, Lagunas +5 more
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The Senescence-Associated Secretory Phenotype (SASP) and Redox-Dependent Invasion of Metastatic Cancer Cells [PDF]
, 2012 Throughout your lifetime renewable tissues and those which are exposed to prolonged inflammation experience an accumulation of senescent cells. These cells have previously been shown to acquire the senescence-associated secretory phenotype (SASP) that ...
Pati, Brooke A.
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Natural Products as Anti-Senescence-Associated Secretory Phenotype (SASP) Agents
Current Medicinal ChemistryCellular senescence denotes an irreversible cell-cycle arrest implicated in organismal aging and age-related disorders, distinguished by the Senescence-Associated Secretory Phenotype (SASP). SASP manifests the capacity of senescent cells to secrete a broad array of bioactive molecules-cytokines, chemokines ...
Lina, Yang +4 more
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Circulation, 2022
Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We aimed to assess the prognostic significance of the SASP assessed by a combination of plasma protein biomarkers in human HF. Methods:
Chenao Qian +12 more
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Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We aimed to assess the prognostic significance of the SASP assessed by a combination of plasma protein biomarkers in human HF. Methods:
Chenao Qian +12 more
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Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP)
Dual-faced cellular senescence is responsible for beneficial biological processes and for age-related pathologies. Senescent cells under stable proliferation arrest develop numerous senescence-associated phenotypes such as the potent pro-inflammatory secretome called the senescence-associated secretory phenotype (SASP).Nicolas, Malaquin, Francis, Rodier
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Inflammopharmacology
Cellular senescence is a natural process, where cells permanently stop dividing in response to stress, helping prevent cancer and assist in tissue repair. However, these senescent cells release a variety of inflammatory factors, known as the senescence-associated secretory phenotype (SASP), which, when persistent, can cause chronic inflammation ...
Poonam Sahu, Trilochan Satapathy
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Cellular senescence is a natural process, where cells permanently stop dividing in response to stress, helping prevent cancer and assist in tissue repair. However, these senescent cells release a variety of inflammatory factors, known as the senescence-associated secretory phenotype (SASP), which, when persistent, can cause chronic inflammation ...
Poonam Sahu, Trilochan Satapathy
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2022
ABSTRACT Cellular senescence, irreversible cell cycle arrest, is induced by various triggers including telomere shortening, oncogene activation, and DNA damage. Senescent cells exhibit the senescence-associated secretory phenotype (SASP), a pathological feature that contributes to organismal aging.
Nurhanani Razali +4 more
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ABSTRACT Cellular senescence, irreversible cell cycle arrest, is induced by various triggers including telomere shortening, oncogene activation, and DNA damage. Senescent cells exhibit the senescence-associated secretory phenotype (SASP), a pathological feature that contributes to organismal aging.
Nurhanani Razali +4 more
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Free Radical Biology and Medicine, 2015
Cellular senescence has evolved as one of the protective mechanisms to arrest the growth of cells with oncogenic potential. While senescent cells lose the ability to divide, they remain metabolically active and adapt a senescence-associated secretory phenotype (SASP).
Akshaya Chandrasekaran +3 more
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Cellular senescence has evolved as one of the protective mechanisms to arrest the growth of cells with oncogenic potential. While senescent cells lose the ability to divide, they remain metabolically active and adapt a senescence-associated secretory phenotype (SASP).
Akshaya Chandrasekaran +3 more
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Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
2021Fabiola Olivieri +2 more
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Cancer Research
Abstract Cellular senescence is a stress-induced program following aberrant oncogene activation or administration of cancer therapies, including chemotherapeutic agents and CDK4/6 inhibitors commonly used for treating advanced breast cancers, that results in the proliferative arrest of damaged cells and induction of the senescence ...
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Abstract Cellular senescence is a stress-induced program following aberrant oncogene activation or administration of cancer therapies, including chemotherapeutic agents and CDK4/6 inhibitors commonly used for treating advanced breast cancers, that results in the proliferative arrest of damaged cells and induction of the senescence ...
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