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Toxicology and Applied Pharmacology, 2022
Exposure to inorganic arsenic has been known to induce cancers in various organs, however, the underlying mechanisms remain unclear. Premature senescence refers to the irreversible growth arrest induced by stress stimuli. The senescence-associated secretory phenotype (SASP), particularly in fibroblasts, has been shown to promote cancer development.
Keiko Nohara
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Exposure to inorganic arsenic has been known to induce cancers in various organs, however, the underlying mechanisms remain unclear. Premature senescence refers to the irreversible growth arrest induced by stress stimuli. The senescence-associated secretory phenotype (SASP), particularly in fibroblasts, has been shown to promote cancer development.
Keiko Nohara
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Assessing Functional Roles of the Senescence-Associated Secretory Phenotype (SASP)
2018Cellular senescence is linked to many normal biological processes, including tumor suppression, development, and wound healing, but it is also associated with age-related pathologies such as cancer progression. Numerous functions of senescent cells depend on their ability to secrete bioactive molecules, a characteristic termed the senescence-associated
Nicolas, Malaquin +2 more
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The senescence-associated secretory phenotype and its physiological and pathological implications [PDF]
Nature Reviews Molecular Cell BiologyCellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations, chronic DNA damage responses, and a hypersecretory state known as the ...
Boshi Wang +2 more
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Detecting the Senescence-Associated Secretory Phenotype (SASP) by High Content Microscopy Analysis
2016The diverse arrays of proteins secreted by senescent cells have been described to influence aging and to have both pro-tumorigenic and anti-tumorigenic influences on the surrounding microenvironment. Further characterization of these proteins, known as the senescence-associated secretory phenotype (SASP), and their regulators is required to understand ...
Priya, Hari, Juan Carlos, Acosta
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Molecular Cancer Research, 2019
Abstract Dyskeratosis congenita is a telomere DNA damage syndrome characterized by defective telomere maintenance, bone marrow failure, and increased head and neck cancer risk. The Pot1b−/−;Terc+/− mouse exhibits some features of dyskeratosis congenita, but head and neck cancer was not ...
Angelica M, Lagunas +5 more
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Abstract Dyskeratosis congenita is a telomere DNA damage syndrome characterized by defective telomere maintenance, bone marrow failure, and increased head and neck cancer risk. The Pot1b−/−;Terc+/− mouse exhibits some features of dyskeratosis congenita, but head and neck cancer was not ...
Angelica M, Lagunas +5 more
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, 2012 Throughout your lifetime renewable tissues and those which are exposed to prolonged inflammation experience an accumulation of senescent cells. These cells have previously been shown to acquire the senescence-associated secretory phenotype (SASP) that ...
Pati, Brooke A.
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Detection of the Senescence-Associated Secretory Phenotype (SASP)
2012Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
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Genes & Cells, 2014
To study the cellular senescence mechanisms and senescence-associated secretory phenotype of the tumor cell lines in response to doxorubicin exposure. The cell lines indicated above were used in present study: human fibroblasts lines BJ, human osteosarcoma cell line U-2 OS and gastrointestinal stromal tumor cell line GIST-T1.
B. R Ramazanov +2 more
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To study the cellular senescence mechanisms and senescence-associated secretory phenotype of the tumor cell lines in response to doxorubicin exposure. The cell lines indicated above were used in present study: human fibroblasts lines BJ, human osteosarcoma cell line U-2 OS and gastrointestinal stromal tumor cell line GIST-T1.
B. R Ramazanov +2 more
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Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP)
Dual-faced cellular senescence is responsible for beneficial biological processes and for age-related pathologies. Senescent cells under stable proliferation arrest develop numerous senescence-associated phenotypes such as the potent pro-inflammatory secretome called the senescence-associated secretory phenotype (SASP).Nicolas, Malaquin, Francis, Rodier
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Circulation, 2022
Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We aimed to assess the prognostic significance of the SASP assessed by a combination of plasma protein biomarkers in human HF. Methods:
Chenao Qian +12 more
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Background: Cell senescence is involved in various age-related pathologies, including HF. The SASP is a characteristic secretory phenotype from senescent cells. We aimed to assess the prognostic significance of the SASP assessed by a combination of plasma protein biomarkers in human HF. Methods:
Chenao Qian +12 more
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