Results 161 to 170 of about 10,262,985 (255)

Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death

Journal of Periodontal Research, EarlyView.
Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee, Eun‐Nam Kim, Gil‐Saeng Jeong   +2 more
wiley   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Senescence-Associated Secretory Phenotype as a Key Driver of Intestinal Aging: A Narrative Review

Population aging is accompanied by progressive deterioration of intestinal structure and function, leading to impaired epithelial regeneration, increased intestinal permeability, chronic inflammation, and gut microbiota dysbiosis.
Yustina Nuke Ardiyan, Johana Puspasari Dwi Pratiwi   +1 more
core   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Alleviating effects of plant extracts on senescence associated secretory phenotype (SASP)

Masterarbeit Wien, FH Campus Wien ...
openaire   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source