Results 221 to 230 of about 666,129 (262)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence-Associated Traits. [PDF]

Aging Cell
Abdelmohsen K, Martindale JL, Rossi M, Shin CH, Pal A, Munk R, Salamini-Montemurri M, Baranzini M, Arends EM, Mustapic M, Lee Y, Lee JN, Popma SH, Hu J, Duda N, Nogueras-Ortiz CJ, Kapogiannis D, Cui CY, Gorospe M.   +18 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Epithelial AhR Suppresses Allergen-Induced Oxidative Stress and Senescence via c-Myc Regulation. [PDF]

Antioxidants (Basel)
Chen Z, Gu W, Wan R, Zeng Y, Xiang X, Ouyang R, Gao P.   +6 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Renal podocyte senescence in human obesity detected by urinary extracellular vesicles. [PDF]

EBioMedicine
Zhang L, Al-Saeedi M, Denic A, Jordan KL, Yang N, Yuan F, Zhu X, Xue A, Tang H, Eirin A, Lerman A, Fidler M, Hickson LJ, Rule AD, Kukla A, Lerman LO.   +15 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

From Neuron-Centric to Glia-Centric: How Aging Glial Networks Drive Neurodegenerative Disease. [PDF]

J Neurochem
Hayashide LS, Pessoa B, Dias G, Pontes B, Pinto RS, Diniz LP.   +5 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Heme drives cardiac endothelial senescence in sepsis via STING activation. [PDF]

Cell Death Dis
Li T, Zhu P, Wang J, Zhang T, Adams J, Tu F, Garbe C, Zhang X, Liu L, Singh K, Williams DL, Li C, Wang X.   +12 more
europepmc   +1 more source