Results 21 to 30 of about 669,007 (261)
Cells, 2022 Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral infection induces acute pulmonary epithelial senescence followed by fibrosis ...
Xiaojing Hong +4 more
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The intrinsic stiffness of human trabecular meshwork cells increases with senescence. [PDF]
, 2015 Dysfunction of the human trabecular meshwork (HTM) plays a central role in the age-associated disease glaucoma, a leading cause of irreversible blindness.
Chang, Yow-Ren +4 more
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Crosstalk between p53 modifiers at PML bodies
Molecular & Cellular Oncology, 2018 Tumor protein p53 (TP53, best known as p53), the most frequently mutated tumor suppressor in cancer, plays a central role in cell fate decisions induced by DNA damage.
Sonja Matt, Thomas G Hofmann
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Cell Death and Disease, 2022 During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression.
Paula Carpintero-Fernández +10 more
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SWI/SNF regulates a transcriptional programme that induces senescence to prevent liver cancer [PDF]
, 2016 Oncogene-induced senescence (OIS) is a potent tumour suppressor mechanism. To identify senescence regulators relevant to cancer, we screened an shRNA library targeting genes deleted in hepatocellular carcinoma (HCC).
Banito, A +16 more
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Bone marrow senescence and the microenvironment of hematological malignancies [PDF]
, 2020 Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M. +3 more
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Capturing and Selecting Senescence Variation in Wheat
Frontiers in Plant Science, 2021 Senescence is a highly quantitative trait, but in wheat the genetics underpinning senescence regulation remain relatively unknown. To select senescence variation and ultimately identify novel genetic regulators, accurate characterization of senescence ...
Elizabeth A. Chapman +3 more
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Petal Senescence: New Concepts for Ageing Cells [PDF]
, 2009 Senescence in flower petals can be regarded as a form of programmed cell death (PCD), being a process where cells or tissues are broken down in an orderly and predictable manner, whereby nutrients are re-used by other cells, tissues or plant parts.
Doorn, W.G., van, Woltering, E.J.
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Wheat leaf senescence and its regulatory gene network
Crop Journal, 2021 Wheat leaf senescence is a developmental process that involves expressional changes in thousands of genes that ultimately impact grain protein content (GPC), grain yield (GY), and nitrogen use efficiency.
Nigarin Sultana +3 more
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EBioMedicine, 2019 Background: Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases.
LaTonya J. Hickson +32 more
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