Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice. [PDF]
Exploration (Beijing)The accumulation of senescent cells and their secretion of senescence‐associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Zhu Y +14 more
europepmc +5 more sources
Could Hyaluronic Acid Be Considered as a Senomorphic Agent in Knee Osteoarthritis? A Systematic Review [PDF]
Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending.
Andrea Bernetti +6 more
doaj +4 more sources
Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones [PDF]
CellsRepurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We performed a repurposing screen of 240 clinically approved molecules in
Laura R. Bramwell +2 more
doaj +7 more sources
Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema [PDF]
Experimental and Molecular Medicine, 2023 Senescence, a hallmark of aging, is a factor in age-related diseases (ARDs). Therefore, targeting senescence is widely regarded as a practicable method for modulating the effects of aging and ARDs.
Jung-Jin Park +8 more
doaj +4 more sources
Biology, 2023 Aging is related to a low-grade and sterile inflammation called inflammaging, recognized as the main risk factor for age-related disease (ARD) development.
Giulia Matacchione +6 more
doaj +4 more sources
Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s disease [PDF]
Frontiers in Neurology, 2023 Drosophila melanogaster is a valuable model organism for a wide range of biological exploration. The well-known advantages of D. melanogaster include its relatively simple biology, the ease with which it is genetically modified, the relatively low ...
Sean J. Miller +4 more
doaj +4 more sources
Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models. [PDF]
PharmaceuticsBackground/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Park S +6 more
europepmc +2 more sources
Targeting SASP with FDA-approved agents: minoxidil and diazoxide as potential senomorphic agents in cancer therapy [PDF]
Türk Biyokimya DergisiChemotherapy-induced senescent cells are recognized to lead to cancer progression and resistance to treatment by releasing factors associated with the senescence-associated secretory phenotype (SASP).
Simay Demir Yaprak Dilber +4 more
doaj +2 more sources
The Senotherapeutic Effects of APPA (Apocynin [AP] and Paeonol [PA]) on Senescent Human Chondrocytes. [PDF]
Pharmaceuticals (Basel)Background/Objectives: Osteoarthritis (OA) is a complex joint disease involving chronic inflammation, aging, and obesity, affecting nearly 6 million people worldwide.
Fernández-Moreno M +6 more
europepmc +2 more sources
The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action. [PDF]
Pharmaceuticals (Basel)Background: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Della Vedova L +4 more
europepmc +2 more sources