Results 171 to 180 of about 1,609 (186)

Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway

International Journal of Biological Sciences
Background: Cellular senescence has emerged as a pivotal focus in cardiovascular research. This study investigates the previously unrecognized role of cellular senescence in septic cardiomyopathy (SCM) and evaluates senomorphic therapy using ruxolitinib (Rux) as a potential treatment option.
Yang, Boshen, Li, Taixi, Wang, Zhixiang, Zhu, Yuankang, Niu, Kaifan, Hu, Sien, Lin, Zhiqi, Zheng, Xinjie, Jin, Xian, Shen, Chengxing   +9 more
exaly   +3 more sources

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Senomorphic, senolytic, and rejuvenation therapies

2022
Xiang Yang Zhu, Lilach O. Lerman
openaire   +1 more source

HYDROCHLOROTHIAZIDE AS A NEW SENOMORPHIC DRUG CANDIDATE

Amaç: Konvansiyonel kanser tedavisinde kullanılan kemoterapötiklerin hem kanser hem de kanser olmayan hücrelerde hücresel senesensi indüklediği bilinmektedir. Senesent hücrelerin önemli özellikleri, hücre morfolojilerinde belirgin değişikliklerin olması ve bu hücrelerden senesens ilişkili sekretuvar fenotip (SASP) olarak adlandırılan çeşitli sitokin ...
Şimay Demir, Yaprak Dilber, Akgül, Senem   +1 more
openaire   +1 more source

Dapagliflozin Exerts Senomorphic Effects on Adriamycin-Induced Podocyte Injury via Modulation of Complosome

Journal of the American Society of Nephrology, 2023
Giuseppe Castellano, Min Li, Deborah Mattinzoli, Silvia Armelloni, Masami Ikehata, Carlo Alfieri   +5 more
openaire   +1 more source

Shotgun Study Reveals Senomorphic Targets Based on SASP Mediated by SEV

Cells have the capacity to modulate the microenvironment through the secretion of molecules (cytokines, chemokines, matrix proteins…) and vesicles, which vary according to the pathology involved, such as cancer or the natural process such as senescence.
Lucio-Gallego, Sergio, Mato-Basalo, Rocío, Alarcón-Veleiro, Carmen, Berjawi, Lama, López-Calvo, Ismael, Carrera, Mónica, Gutiérrez, Lola, Gil, Concha, Mateos, Jesús, Arufe, María C., Fafián-Labora, Juan   +10 more
openaire   +1 more source

RISING STARS: Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes

Journal of Molecular Endocrinology
Abstract Type 2 diabetes mellitus (DM) is closely associated with cellular senescence (SnC), a state of irreversible cell cycle arrest marked by functional decline. Preventing cellular senescence in already diagnosed DM patients is crucial for limiting disease progression and the onset of co-morbidities.
Mari van de Vyver, Saiuree Govender, Kelly Petersen-Ross, Kayla Howard   +3 more
openaire   +1 more source

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin

Science Advances, 2021
Cheng Xu, Wei-Bin Shen, Hidetoshi Hasuwa
exaly  

Metabolite Profiling of Allium hookeri Leaves Using UHPLC-qTOF-MS/MS and the Senomorphic Activity of Phenolamides

Nutrients, 2023
Thi Phuong Doan, Mi Zhang, Jorge E. Ponce-Zea   +2 more
exaly  

Senescence and cancer — role and therapeutic opportunities

Nature Reviews Clinical Oncology, 2022
Clemens A Schmitt, Marco Demaria
exaly  

Metabolite Profiling of Rambutan (Nephelium lappaceum L.) Seeds Using UPLC-qTOF-MS/MS and Senomorphic Effects in Aged Human Dermal Fibroblasts

Nutrients, 2020
Hyo-Moon Cho, Eun-Jin Park, Mi Zhang
exaly