Results 11 to 20 of about 1,153 (147)

PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration [PDF]

Advanced Science
Cellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting senescence markers and the senescence‐associated secretory phenotype (SASP), remains
Sheng Liu, Kanglu Li, Yuxin He, Sheng Chen, Wenbo Yang, Xuanzuo Chen, Shiqing Feng, Liming Xiong, Yizhong Peng, Zengwu Shao   +9 more
doaj   +4 more sources

Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases. [PDF]

Int J Mol Sci
Cellular senescence, a state of stable cell cycle arrest accompanied by a complex senescence-associated secretory phenotype (SASP), is a fundamental biological process implicated as a key driver of lung aging and lung age-related diseases (LARDs).
Ozdemir SA, Faizan MI, Kaur G, Shaikh SB, Ul Islam K, Rahman I.   +5 more
europepmc   +7 more sources

Mitigating Pro-Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy. [PDF]

Aging Cell
ABSTRACT Senescent cells are known to contribute to aging and age‐related diseases. One key way they influence aging is by secreting senescence‐associated secretory phenotype (SASP) factors along with several damage‐associated molecular pattern (DAMP) molecules.
Barkovskaya A, Brauning A, Thambala A, Bhardwaj K, Chamoli M, Rane A, Andersen JK, Sharma A.   +7 more
europepmc   +6 more sources

Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect. [PDF]

Int J Mol Sci
Cellular senescence is closely connected with cancer progression, recurrence, and metastasis. Senotherapy aims to soothe the harmful effects of senescent cells either by inducing their apoptosis (senolytic) or by suppressing the senescence-associated secretory phenotype (SASP) (senomorphic).
Henschke A, Grześkowiak B, Ivashchenko O, Sánchez-Cerviño MC, Coy E, Moya S.   +5 more
europepmc   +5 more sources

Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics. [PDF]

Drug Des Devel Ther
Alum EU, Izah SC, Uti DE, Ugwu OP, Betiang PA, Basajja M, Ejemot-Nwadiaro RI.   +6 more
europepmc   +4 more sources

Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies. [PDF]

Int J Mol Sci
Senolytic and senomorphic therapies gain more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the “normal” cells. Ageing is not a disease. Clinical studies on healthy people will be difficult to conduct.
Imb M, Véghelyi Z, Maurer M, Kühnel H.
europepmc   +5 more sources

Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar, Şerife Ayaz-Güner, Zeynep Gunaydin, Musa Karakukcu, Gianfranco Peluso, Giovanni Di Bernardo, Servet Özcan, Servet Özcan, Umberto Galderisi, Umberto Galderisi, Umberto Galderisi   +10 more
doaj   +7 more sources

Effective and Stable Senomorphic Apigenin Delivery System Obtained by Supercritical Carbon Dioxide Processing. [PDF]

Int J Mol Sci
Apigenin (AP) is a natural flavonoid with senomorphic potential and neuroprotective action; however, poor aqueous solubility (<1 μg/mL) limits its bioavailability and therapeutic use. Therefore, the aim of this study was to obtain an amorphous dispersion of AP and evaluate its biological properties.
Stasiłowicz-Krzemień A, Rosiak N, Racaniello GF, Denora N, Cielecka-Piontek J.   +4 more
europepmc   +5 more sources

Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging [PDF]

Scientific Reports
Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging.
Patrick Bogdanowicz, Paul Bensadoun, Maïté Noizet, Benoît Béganton, Armony Philippe, Sandrine Alvarez-Georges, Gautier Doat, Amélie Tourette, Sandrine Bessou-Touya, Jean-Marc Lemaitre, Hélène Duplan   +10 more
doaj   +2 more sources

The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases [PDF]

Biomedicines
Cellular senescence is a permanent cell cycle arrest that plays a critical role in the development and pathogenesis of age-related diseases. This paper aims to present the biological mechanisms of cellular senescence and the role of the senescence ...
Krupa Z, Wrona J, Zawadzka M, Rydzek J, Lizon J, Kalemba P, Kochman K, Iwaszkiewicz P, Iwanowski R, Woźniak S.   +9 more
europepmc   +2 more sources