Results 21 to 30 of about 1,153 (147)

An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening. [PDF]

Commun Biol
Study of cellular senescence is critical in aging research and anti-senescence therapy drug development. Current methods for the evaluation of the widely accepted cellular senescence marker senescence-associated beta galactosidase (SA-β-gal) activity ...
Hu Y, Xue X, Han T, Li Y, Zhang T, Lu T, Zhang P.   +6 more
europepmc   +2 more sources

Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation. [PDF]

Antioxidants (Basel)
Ferroptosis and senescence are unique cellular processes that lead to irreversible cell abnormalities and tissue damage in many diseases, such as cancer, neurodegeneration, cardiac, liver, and kidney damage.
Kourti M, Kontoghiorghes GJ.
europepmc   +2 more sources

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]

The FEBS Journal, 2022
The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, Laura J. Niedernhofer, Paul D. Robbins   +4 more
openalex   +3 more sources

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age-Related Conditions in Mice. [PDF]

Adv Sci (Weinh)
Cellular senescence is a cell fate triggered by stressful stimuli and displays a hypersecretory feature, the senescence‐associated secretory phenotype (SASP). Senescent cell burden increases with aging and contributes to age‐related organ dysfunction and
Zhang H, Xu Q, Jiang Z, Sun R, Wang Q, Liu S, Luan X, Campisi J, Kirkland JL, Zhang W, Sun Y.   +10 more
europepmc   +2 more sources

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science
Cellular senescence, a fundamental hallmark of aging, plays a paradoxical, often pro‐tumorigenic role in cancer. This malignancy is largely driven by the senescence‐associated secretory phenotype (SASP), yet the mechanisms that govern the production of a
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
doaj   +2 more sources

Sex-Specific Protection of Endothelial Function after Vascular Ischemia/Reperfusion Injury by the Senomorphic Agent Ruxolitinib [PDF]

International Journal of Molecular Sciences, 2023
Ischemia/reperfusion (I/R)-induced endothelial dysfunction occurs in various cardiovascular disorders. I/R injury is partially driven by the release of cytokines. Known for its use in senotherapy, the JAK inhibitor ruxolitinib is able to block the release of cytokines.
Lars Saemann, Paula Naujoks, Lotta Hartrumpf, Sabine Pohl, Andreas Simm, Gábor Szabó   +5 more
openalex   +3 more sources

A Senomorphic‐Conjugated Scaffold for Application of Senescent Cells in Regenerative Medicine [PDF]

Advanced Therapeutics, 2023
AbstractProcuring a sufficient amount of cells is essential for cell‐based regenerative therapy. However, the application of senescent cells replicated using cell culture is limited because the cells have lost their regenerative ability or produce deleterious senescence‐associated secretory phenotypes (SASPs).
Wenqi Deng, Jun-ichiro JO, Tomonari Tanaka, Hidetoshi Morikuni, Yoshiya Hashimoto, Naoyuki Matsumoto, Yoshitomo Honda   +6 more
openalex   +2 more sources

Emerging roles of senolytics/senomorphics in HIV-related co-morbidities [PDF]

Biochemical Pharmacology
Human immunodeficiency virus (HIV) is known to cause cellular senescence and inflammation among infected individuals. While the traditional antiretroviral therapies (ART) have allowed the once fatal infection to be managed effectively, the quality of life of HIV patients on prolonged ART use is still inferior. Most of these individuals suffer from life-
Gagandeep Kaur, Md. Sohanur Rahman, Sadiya Bi Shaikh, Kingshuk Panda, Srinivasan Chinnapaiyan, Maria Santiago Estevez, Xia Li, Hoshang Unwalla, Irfan Rahman   +8 more
openalex   +3 more sources

Defining Microbiota-Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age-Related T Cell Senescence. [PDF]

Aging Cell
Rees NP, Conway J, Dugan B, Amir SS, Parker A, Carding SR, Duggal NA.   +6 more
europepmc   +3 more sources

Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration. [PDF]

Biomolecules
Cellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Delenko J, Hyman N, Chatterjee PK, Safaric Tepes P, Shih AJ, Xue X, Gurney J, Baker AG, Wei C, Munoz Espin D, Fruk L, Gregersen PK, Metz CN.   +12 more
europepmc   +2 more sources