SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY
Central Asian Journal of Medical Hypotheses and EthicsAging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev, Prim B. Singh
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Frentizole derivatives with mTOR inhibiting and senomorphic properties [PDF]
Biomedicine & Pharmacotherapy, 2023 Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has been revealed.
Zofia Chrienova +21 more
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Synergistic targeting of senolytic and senomorphic action with dual-engineered biomimetic macrophage nanovesicles for mitigating osteoarthritis. [PDF]
Bioact MaterOsteoarthritis (OA), a leading cause of chronic disability worldwide, is increasingly recognized to be driven by the accumulation of senescent chondrocytes (sCDs) and their deleterious pro-inflammatory senescence-associated secretory phenotype (SASP ...
Peng W +9 more
europepmc +2 more sources
Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice [PDF]
Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced response to vaccine regimens.
Carla Luís +5 more
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Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis [PDF]
International Journal of Molecular Sciences, 2022 Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA treatment is currently not available. Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in the etiology of OA.
Pei-Wei Weng +7 more
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Correction to "Rutin is a Potent Senomorphic Agent to Target Senescent Cells and Can Improve Chemotherapeutic Efficacy". [PDF]
Aging Celleuropepmc +5 more sources
Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy [PDF]
Aging Cell, 2023 AbstractAging is a major risk factor for most chronic disorders, for which cellular senescence is one of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence‐associated secretory phenotype (SASP), which significantly contributes to organismal aging and age‐related disorders.
Hanxin Liu +9 more
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Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells. [PDF]
Aging CellJiang B +6 more
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HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells [PDF]
Aging, 2021 The senescence of retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a predominant chaperone that regulates cellular homeostasis under divergent physio-pathological conditions including senescence.
Chen, Dan-Dan +12 more
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Aging Pathobiology and Therapeutics, 2023 Background: Senomorphics have been considered as an effective alternative paradigm of senotherapeutics to regulate cellular senescence and related disorders by inhibiting the deleterious effects of senescence-associated secretory phenotype (SASP) components secreted by senescent cells without inducing cell death.
Yuqi Xie +6 more
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