Results 41 to 50 of about 1,153 (147)

Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission

Biomedicine & Pharmacotherapy, 2023
With an aging population and the numerous health impacts associated with old age, the identification of anti-aging drugs has become an important new research direction. Although mitochondria have been recognized to affect aging, anti-aging drugs specifically targeting the mitochondria are less well characterized. In this study, diphenyleneiodonium (DPI)
Keng-Mao Liao, Chih‐Jung Chen, Weijia Luo, Chen-Wei Hsu, Sung‐Liang Yu, Pan‐Chyr Yang, Kang‐Yi Su   +6 more
openalex   +3 more sources

Senopathies—Diseases Associated with Cellular Senescence

Biomolecules, 2023
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak, Markus Schosserer, Johannes Grillari   +2 more
doaj   +1 more source

Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in chronic kidney disorder induced vascular calcification. [PDF]

Int J Immunopathol Pharmacol
Arora S, Halsey G, Zohora FT, Swiss A, Vyavahare N.   +4 more
europepmc   +4 more sources

Monoterpenoids from the Roots of <i>Liquidambar formosana</i> (Formosan Sweet Gum) Exhibit Senomorphic Activity Against Cellular Senescence. [PDF]

Nutrients
Le MTT, Vu QH, Mai VH, Ponce-Zea JE, Choi S, An JP, Oh WK.   +6 more
europepmc   +3 more sources

The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy. [PDF]

Mol Cancer
Cellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP).
Cao L, Li K, Li Q, Tong Q, Wang Y, Huang L.   +5 more
europepmc   +2 more sources

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin [PDF]

Science Advances, 2020
A microRNA-activated pathway in maternal diabetes–induced neuroepithelial cell senescence leads to neural tube defects.
Cheng Xu, Wei-Bin Shen, E. Albert Reece, Hidetoshi Hasuwa, Christopher Harman, Sunjay Kaushal, Peixin Yang   +6 more
openaire   +3 more sources

From Neuron-Centric to Glia-Centric: How Aging Glial Networks Drive Neurodegenerative Disease. [PDF]

J Neurochem
During aging, progressive alterations in glial networks reshape intercellular communication within the central nervous system. In the young brain, astrocytes and microglia actively regulate metabolic, immune, and synaptic processes that sustain neural circuit stability.
Hayashide LS, Pessoa B, Dias G, Pontes B, Pinto RS, Diniz LP.   +5 more
europepmc   +2 more sources

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent. [PDF]

Aging Dis
Assessing impact on the hallmarks of aging has emerged as a novel method for prioritizing dual-purpose longevity therapeutic targets and developing drugs simultaneously targeting aging and disease. Cellular senescence, a central hallmark of aging, progressively induces cellular growth arrest and accelerates the production of a pro-inflammatory ...
Tang Q, Xiao D, Veviorskiy A, Xin Y, Lok SWY, Pulous FE, Zhang P, Zhu Y, Ma Y, Hu X, Gu S, Zong C, Mukba S, Korzinkin M, Pun FW, Zhang M, Aliper A, Wu L, Ren F, Zhang L, Zhavoronkov A.   +20 more
europepmc   +3 more sources

Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes

Arthritis Research & Therapy, 2023
Background Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence ...
Yu-Hsiu Chen, Xin Zhang, David Attarian, Virginia Byers Kraus   +3 more
doaj   +1 more source

Single-cell profiling unveils a geroprotective role of Procyanidin C1 in hematopoietic immune system via senolytic and senomorphic effects. [PDF]

NPJ Aging
Liu X, Liu Y, Gao Y, Zhang C, Gu C, Lv J, Wu J, Su W.   +7 more
europepmc   +3 more sources