Results 71 to 80 of about 1,153 (147)

Effects of N-acetylcysteine on aging cell and obesity complications in obese adults: a randomized, double-blind clinical trial

Frontiers in Nutrition, 2023
BackgroundWe decided to conduct this study with the aim of investigating the effects of N-Acetylcysteine (NAC) on obesity complications and senescence of visceral adipose tissue in obese adults.Methods and analysisThe present study was conducted as a ...
Mohammad Hassan Sohouli, Ghazaleh Eslamian, Nasser Malekpour Alamdari, Maryam Abbasi, Sepideh Fazeli Taherian, Diba Behtaj, Hamid Zand   +6 more
doaj   +1 more source

Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae

Aging Cell, Volume 25, Issue 3, March 2026.
Aging is associated with a senescent‐like phenotype in neutrophils that emerges in bone marrow cells; however, many facets of this phenotype are only fully acquired upon entry into peripheral tissues. This neutrophil senescent‐like phenotype is in part driven by TNFα and impairs resistance of aged hosts to S. pneumoniae. Created in BioRender. Boughanem
Michael C. Battaglia, Manmeet Bhalla, Brandon Marzullo, Anagha Betadpur, Alexsandra P. Lenhard, Rania Hassan Mohamed, Murat C. Kalem, Lauren R. Heinzinger, Pathricia A. Leus, Samuel Labarron, Lee Ann Garrett‐Sinha, Joan Mecsas, Anna Blumental‐Perry, Elsa N. Bou Ghanem   +13 more
wiley   +1 more source

Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage

Aging Cell, Volume 25, Issue 2, February 2026.
Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell, Eleanor J. Jones, Nima Gharahdaghi, Daniel J. Wilkinson, Kenneth Smith, Philip J. Atherton, Anna K. Simon, Lynne S. Cox, Ghada Alsaleh   +8 more
wiley   +1 more source

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits

Aging Cell, Volume 25, Issue 2, February 2026.
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen, Jennifer L. Martindale, Martina Rossi, Chang Hoon Shin, Apala Pal, Rachel Munk, Martin Salamini‐Montemurri, Mirko Baranzini, Ethan M. Arends, Maja Mustapic, Yuta Lee, Jau‐Nan Lee, Sicco H. Popma, Justin Hu, Nathan Duda, Carlos J. Nogueras‐Ortiz, Dimitrios Kapogiannis, Chang‐Yi Cui, Myriam Gorospe   +18 more
wiley   +1 more source

Engineering Aging: Approaches to Model and Deconstruct Biological Complexity

Advanced Materials, Volume 38, Issue 1, 2 January 2026.
The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar, Sunny Shinchen Lee, Thomas R. Cox, Yu Suk Choi, Steven G. Wise, Jennifer L. Young, Giselle C. Yeo, Khoon S. Lim   +7 more
wiley   +1 more source

Integrative Omics Reveal Female‐Specific Benefits of p16+ Cell Clearance in Aging Mice

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Aging causes accumulation of p16⁺ senescent cells that promote inflammation and dysfunction. Multi‐omics analyses reveal striking sex differences in senescent cell burden and clearance: females accumulate more p16⁺ cells, especially in the liver, and their removal rejuvenates molecular and functional profiles.
Yao Lin, Boshi Wang, Mengling Huang, Justina C. Wolters, Marco Demaria   +4 more
wiley   +1 more source

Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

Aging Cell, Volume 25, Issue 1, January 2026.
The SC subtype with a pro‐inflammatory, proapoptotic, tissue‐damaging SASP is susceptible to senolytics. The SC subset not killed by senolytics has a pro‐growth/repair SASP. “Senosensitizers” that induce senolytic‐resistant SCs to be converted into SCs that are susceptible to senolytics could enable removal of relatively silent SCs.
Utkarsh Tripathi, Masayoshi Suda, Vagisha Kulshreshtha, Bryan T. Piatkowski, Allyson K. Palmer, Nino Giorgadze, Christina Inman, Nathan Gasek, Ming Xu, Kurt O. Johnson, Tamar Pirtskhalava, Selim Chaib, Larissa P. G. Langhi Prata, Yi Zhu, Renuka Kandhaya‐Pillai, Stefan G. Tullius, Saranya P. Wyles, Rambabu Majji, Hari Krishna Yalamanchili, David B. Allison, Tamar Tchkonia, James L. Kirkland   +21 more
wiley   +1 more source

Cellular Senescence, Inflammaging and Cardiovascular Disease

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Aging is the most important yet unmodifiable risk factor for cardiovascular disease (CVD). As a result, targeting cardiovascular aging has emerged as a promising strategy to promote long‐term cardiovascular health. This review summarizes current knowledge on the effects of aging within the cardiovascular system as well as systemic processes ...
Lukas Zanders, Denada Arifaj, Julian U. G. Wagner, Stefanie Dimmeler   +3 more
wiley   +1 more source

The role of p21 in cellular senescence and aging-related diseases

Molecules and Cells
: During the aging process or disease progression, normal cells and tissues in the body undergo various stresses, leading to cell damage and the need for repair, adaptation, apoptosis, or defense responses.
Jiayu Yan, Siyi Chen, Zimei Yi, Ruowen Zhao, Jiayu Zhu, Shuwen Ding, Junhua Wu   +6 more
doaj   +1 more source

Cellular Senescence in the Ascending Aorta and Complexity of Coronary Atherosclerosis

Journal of Aging Research, Volume 2026, Issue 1, 2026.
Background Cellular senescence might have a key role in the pathogenesis of vascular aging and atherosclerosis. However, human data directly linking cellular senescence in the vascular tissue with coronary artery disease (CAD) are limited. This study aimed to investigate the relationship between the proportion of senescent cells in the ascending aorta ...
Hanife Abanus, Mutlu Vural, Fahrettin Katkat, Esra Paşaoğlu, Abdullah Olgun, Bülent Mert, Udhaya Kumar Siva Kumar   +6 more
wiley   +1 more source