Results 81 to 90 of about 1,153 (147)

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Editorial: Cellular senescence in physiology and pathophysiology

Frontiers in Physiology, 2023
Mustafa Ark, Mohammad Nasir Uddin
doaj   +1 more source

Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice

FEBS Open Bio
SARS‐CoV‐2 infection can lead to severe COVID‐19, particularly in elderly individuals and those with compromised immunity. Cellular senescence has been implicated as a key pathogenic mechanism.
Ju Hwan Jeong, Sun‐Ok Kim, Seong Cheol Min, Eung‐Gook Kim, Min‐Suk Song, Eun‐Young Shin   +5 more
doaj   +1 more source

Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Pharmaceuticals
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier, Saifudeen Ismael, Gregory Jaye Bix   +2 more
doaj   +1 more source

The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications

Experimental Gerontology
Osteoarthritis (OA) is a common and debilitating joint disorder, with its pathogenesis significantly influenced by factors such as aging and obesity.
Kai Huang, Haili Cai
doaj   +1 more source

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Nature Communications
Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang, Jianwei You, Xincheng Yang, Ruishu Jiao, Jie Xu, Yue zhang, Wen Mi, Lingzhi Zhu, Youqiong Ye, Ruobing Ren, Delin Min, Meilin Tang, Li Chen, Fuming Li, Pingyu Liu   +14 more
doaj   +1 more source

Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells

Targets
Taken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Hejing Tang, Xu Zhang, Senyang Hu, Yuhan Song, Wenhua Jin, Jianmin Zou, Yan Zhang, Jiayue Guo, Peng An, Junjie Luo, Pengjie Wang, Yongting Luo, Yinhua Zhu   +12 more
openaire   +1 more source

Activatable and Self-Monitoring Hydrogen Sulfide-Based Molecular Senomorphics for Visualized Regulation of Cellular Senescence

, 2023
Jili Li, Yuqi Xie, Jian Wang, Linlin Wang, Yinghao Xia, Yanlan Liu, Weihong Tan   +6 more
openalex   +2 more sources

Apigenin and Phloretin Combination for Skin Aging and Hyperpigmentation Regulation

Cosmetics
Melasma is a pathology with multifactorial causes that results in hyperpigmentation of sun-exposed areas, particularly facial skin. New treatments targeting the different factors regulating this condition need to be effective with and have limited ...
Alfredo Martínez-Gutiérrez, Javier Sendros, Teresa Noya, Mari Carmen González   +3 more
doaj   +1 more source

Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities

Cell Regeneration
The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen   +7 more
doaj   +1 more source