Results 151 to 160 of about 728 (163)
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Senoprevention and senotherapy – new pharmacological strategies for age-related diseases?
Farmacja polskaStarzenie organizmu jest procesem, który zależy od wielu czynników, a charakterystyczne cechy starzenia się ujawniają swój postęp na trzech różnych poziomach: molekularnym, komórkowym oraz systemowym.
Magdalena Jurzak
semanticscholar +1 more source
Effect of the putative senotherapy, Fisetin on small airway epithelial cells in COPD
Mechanisms of lung injury and repairJ. Devulder +5 more
semanticscholar +2 more sources
A Senescent Subset in Human Hematopoietic Stem Cell (HSC) Compartment As Target for Senotherapy
BloodBackground: In mouse model for aging studies, clearance of senescent cells in the hematopoietic stem cell (HSC) compartment has been shown to rejuvenate the hematopoietic system.
Laura Poisa-Beiro +11 more
semanticscholar +1 more source
Angewandte Chemie
Drug resistance is a significant challenge for tumor therapy. Activating immunity is an effective method to combat drug-resistant tumors. Utilizing metallic chemotherapeutic agents to induce non-apoptotic programmed cell death is a practical approach to ...
Jinrong Yang +6 more
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Drug resistance is a significant challenge for tumor therapy. Activating immunity is an effective method to combat drug-resistant tumors. Utilizing metallic chemotherapeutic agents to induce non-apoptotic programmed cell death is a practical approach to ...
Jinrong Yang +6 more
semanticscholar +1 more source
Biomaterials
Tumor cellular senescence, characterized by reversible cell cycle arrest following anti-cancer therapies, presents a complex paradigm in oncology. Given that senescent tumor cells may promote angiogenesis, tumorigenesis, and metastasis, selective killing
Tao Wang +13 more
semanticscholar +1 more source
Tumor cellular senescence, characterized by reversible cell cycle arrest following anti-cancer therapies, presents a complex paradigm in oncology. Given that senescent tumor cells may promote angiogenesis, tumorigenesis, and metastasis, selective killing
Tao Wang +13 more
semanticscholar +1 more source
Metabolic remodeling in cancer and senescence and its therapeutic implications.
Trends in endocrinology and metabolismCellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging.
Yeonju Kim +3 more
semanticscholar +1 more source
Biochemical Society Transactions
Cellular senescence, a form of terminal cell cycle arrest, is as a key driver of organismal ageing and an important factor in age-related diseases. Insights into the senescent phenotype have led to the development of novel therapeutic strategies, collectively known as senotherapies, that aim to ameliorate the detrimental effects of senescent cell ...
Vinesh Dhokia +4 more
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Cellular senescence, a form of terminal cell cycle arrest, is as a key driver of organismal ageing and an important factor in age-related diseases. Insights into the senescent phenotype have led to the development of novel therapeutic strategies, collectively known as senotherapies, that aim to ameliorate the detrimental effects of senescent cell ...
Vinesh Dhokia +4 more
openaire +2 more sources
Targeting immunosenesence promotes clearance of senescent cells
Immunity & AgeingKnown as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age ...
Anteneh Mehari Tizazu +2 more
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Journal of Medicinal Chemistry
Psoriasis is a multifactorial inflammatory disorder characterized by therapeutic resistance and high recurrence rates, with complex unmet clinical demands necessitating novel therapeutic strategies.
Yangxin Yu +9 more
semanticscholar +1 more source
Psoriasis is a multifactorial inflammatory disorder characterized by therapeutic resistance and high recurrence rates, with complex unmet clinical demands necessitating novel therapeutic strategies.
Yangxin Yu +9 more
semanticscholar +1 more source