Results 141 to 150 of about 646 (170)
Intervention treatment reducing cellular senescence inhibits tubulointerstitial fibrosis in diabetic mice following acute kidney injury. [PDF]
Clin Sci (Lond)Tesch GH +3 more
europepmc +1 more source
Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions. [PDF]
Signal Transduct Target TherMikawa T +27 more
europepmc +1 more source
Healthy Ageing and Longevity, 2020 Cellular senescence is a stress and repair response that protects us from cancer and contributes to tissue homeostasis by inducing a stable cell cycle arrest and imposing a secretory phenotype. Senescent cells are held in check to avoid their aberrant proliferation while at the same time they serve as new signaling nodes to orchestrate tissue repair ...
Pilar Picallos-Rabina +2 more
exaly +3 more sources
Senotherapy, cancer, and aging
Journal of Geriatric OncologyWe aimed to highlight the effects of senotherapy on the prevention and treatment of cancer in older individuals. The aim of senotherapy is to eliminate senescent cells. These cells express the senescence-associated secretory phenotype (SASP). With production of inflammatory cytokines, growth factors, and different type of proteases, the SASP is ...
Claire Falandry, Silvio Monfardini
exaly +6 more sources
Senotherapy: growing old and staying young?
Pflugers Archiv European Journal of Physiology, 2017 Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair.
Roland Schmitt, Schmitt Roland
exaly +4 more sources
Targeting normal and cancer senescent cells as a strategy of senotherapy
Ageing Research Reviews, 2019 Senotherapy is an antiageing strategy. It refers to selective killing of senescent cells by senolytic agents, strengthening the activity of immune cells that eliminate senescent cells or alleviating the secretory phenotype (SASP) of senescent cells. As senescent cells accumulate with age and are considered to be at the root of age-related disorders ...
Ewa Sikora +2 more
exaly +4 more sources
Senotherapy for attenuation of cellular senescence in aging and organ implantation
Journal of Industrial and Engineering Chemistry, 2018 Abstract Cellular senescence in transplant is induced by aging and therapy-induced stress, which is caused by generation of senescent cells in transplant during engraftment. These senescent cells induce transplant failure due to secretion of senescence-associated secretory phenotype (SASP).
Dong Yun Lee
exaly +4 more sources
Senotherapy preserves resilience in aging
Geriatrics and Gerontology InternationalIn aging societies, social and economic burdens of aging‐related diseases are increasing significantly. Senotherapy, which targets aging by eliminating senescent cells (senolytics) or removing sources of chronic inflammation (senostatics), are proposed as novel strategies for aging‐related diseases.
Kazumichi Yoshida, Hiroshi Kondoh
exaly +4 more sources
Targeted delivery strategy: A beneficial partner for emerging senotherapy
Biomedicine and Pharmacotherapy, 2022 Numerous cutting-edge studies have confirmed that the slow accumulation of cell cycle arrested and secretory cells, called senescent cells (SCs), in tissues is an important negative factor, or even the culprit, in age- associated diseases such as non-alcoholic fatty liver, Alzheimer's disease, type 2 diabetes, atherosclerosis, and malignant tumors ...
Qixiong, Zhang +4 more
exaly +3 more sources