Results 151 to 160 of about 646 (170)
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Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Pharmacological Reviews, 2023An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies. Key traits of senescent cells include cell cycle arrest, apoptosis resistance, and secretome shift to ...
Lucas, Vasco +2 more
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Senotherapy for chronic lung disease
Pharmacological ReviewsChronic respiratory diseases are an enormous burden on healthcare and the third ranked cause of death globally. There is now compelling evidence that acceleration of lung aging and associated cellular senescence is a key driving mechanism of several chronic lung diseases, particularly chronic obstructive pulmonary disease and idiopathic pulmonary ...
Peter J Barnes
exaly +4 more sources
2023
Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent cells fail to repair tissue damage and release an array of inflammatory proteins, known as the ...
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Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent cells fail to repair tissue damage and release an array of inflammatory proteins, known as the ...
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Senotherapies: A novel strategy for synergistic anti-tumor therapy
Drug Discovery Today, 2022Cellular senescence was initially considered an effective antitumor mechanism, and senescence-induced therapy has previously been regarded as an efficient treatment. However, increasing studies have discovered that persistent senescent cells (SNCs) might have unanticipated negative repercussions for antitumor treatment.
Xuxin, Qi, Li, Jiang, Ji, Cao
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Senotherapy: Implications for Transplantation
TransplantationCellular senescence has been identified as a potential driver of age-associated loss of organ function and as a mediator of age-related disease. Novel strategies in targeting senescent cells have shown promise in several organ systems to counteract functional decline, chronic inflammation, and age-dependent loss of repair capacity.
Martin, Jaros, Anette, Melk
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[Senotherapy: Advances and new clinical perspectives].
Medecine sciences : M/S, 2021Cellular senescence has been now shown to be at the root of many degenerative processes that characterize ageing. Thus, in addition to an irreversible proliferative arrest following various stresses or inappropriate stimuli, cellular senescence leads to genetic, epigenetic, metabolic, structural and functional adaptations of the cell.
Damien, Veret, Jean-Marc, Brondello
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2018
Aging brings about many risks factors that can lead to age-related chronic disorders such as atherosclerosis, osteoporosis, and neurodegenerative diseases. Implicated in aging and age-related pathologies, the accumulation of senescent cells can prevent tissue repair and regeneration, leading to loss of physiological function.
Janice Wong +3 more
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Aging brings about many risks factors that can lead to age-related chronic disorders such as atherosclerosis, osteoporosis, and neurodegenerative diseases. Implicated in aging and age-related pathologies, the accumulation of senescent cells can prevent tissue repair and regeneration, leading to loss of physiological function.
Janice Wong +3 more
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Senotherapy: A New Horizon for COPD Therapy.
Chest, 2021There is increasing evidence that COPD is a disease of accelerated lung aging, with the accumulation of senescent cells that lose their ability to repair and secrete multiple inflammatory proteins known as the senescence-associated secretory phenotype (SASP), which mimic the profile of inflammatory mediators secreted in COPD.
Jonathan R, Baker +2 more
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Proteolysis targeting chimeras as senolytics: An emerging senotherapy for combating aging
The Journal of Pharmacology and Experimental TherapeuticsCellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives aging-related phenotypes. Clearance of senescent cells decreases chronic, low-grade inflammation and restores tissue repair capacity, thus improving human health and lifespan.
Alexis B. Cruickshank-Taylor +4 more
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