Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation. [PDF]
Integr Med ResSeok YM +18 more
europepmc +1 more source
Senolytic Therapy in Sleep Apnea: Murky Waters or Fountain of Youth? [PDF]
Am J Respir Crit Care MedJun JC.
europepmc +1 more source
A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows. [PDF]
Inflamm RegenChen B, Li G, Fang Q, Ding P, Gao Y.
europepmc +1 more source
Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic toxicity via regulating ER stress and β-cell apoptosis. [PDF]
Mol CellsKim S, Hwang AR, Kim SH, Lim JH, Woo CH.
europepmc +1 more source
Targeted delivery strategy: A beneficial partner for emerging senotherapy
Biomedicine and Pharmacotherapy, 2022 Numerous cutting-edge studies have confirmed that the slow accumulation of cell cycle arrested and secretory cells, called senescent cells (SCs), in tissues is an important negative factor, or even the culprit, in age- associated diseases such as non-alcoholic fatty liver, Alzheimer's disease, type 2 diabetes, atherosclerosis, and malignant tumors ...
Qixiong Zhang
exaly +3 more sources
Senotherapy preserves resilience in aging
Geriatrics and Gerontology InternationalIn aging societies, social and economic burdens of aging‐related diseases are increasing significantly. Senotherapy, which targets aging by eliminating senescent cells (senolytics) or removing sources of chronic inflammation (senostatics), are proposed as novel strategies for aging‐related diseases.
Takumi Mikawa, Hiroshi Kondoh
exaly +3 more sources
Related searches:
Senotherapy: growing old and staying young?
Pflugers Archiv European Journal of Physiology, 2017Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair.
Roland Schmitt
exaly +3 more sources
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Pharmacological Reviews, 2023An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies. Key traits of senescent cells include cell cycle arrest, apoptosis resistance, and secretome shift to ...
Lucas, Vasco +2 more
openaire +2 more sources
Senotherapies: A novel strategy for synergistic anti-tumor therapy
Drug Discovery Today, 2022Cellular senescence was initially considered an effective antitumor mechanism, and senescence-induced therapy has previously been regarded as an efficient treatment. However, increasing studies have discovered that persistent senescent cells (SNCs) might have unanticipated negative repercussions for antitumor treatment.
Xuxin, Qi, Li, Jiang, Ji, Cao
openaire +2 more sources
Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases [PDF]
International Journal of Molecular Sciences, 2020 The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently needed problem of social relevance.
Alessia Mongelli +2 more
exaly +4 more sources