Results 61 to 70 of about 735,970 (407)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Neuroinflammation Involved in Diabetes-Related Pain and Itch

Frontiers in Pharmacology, 2022
Diabetes mellitus (DM) is a global epidemic with increasing incidence, which results in diverse complications, seriously affects the patient quality of life, and brings huge economic burdens to society.
Xiao-Xia Fang, Xiao-Xia Fang, Heng Wang, Hao-Lin Song, Juan Wang, Zhi-Jun Zhang   +5 more
doaj   +1 more source

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]

, 2019
Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara, Bouchaud, Grégory, Costa, Ana, Denery-Papini, Sandra, Díaz-Perales, Araceli, E.M. Willemsen, Linette, Garrido-Arandia, María, Gavrovic-Jankulovic, Marija, H.M. van Bilsen, Jolanda, Hayen, Simone, L. Bavaro, Simona, L. Roggen, Erwin, Lozano-Ojalvo, Daniel, M. Antunes, Célia, Wróblewska, Mónica   +14 more
core   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Peculiarities detected in formation of speficic hapten sensitization to phenol in children

Analiz Riska Zdorovʹû, 2022
Phenol contamination in ambient air is a factor which creates health risks for children living in a zone influenced by emissions from a ferrous metallurgy enterprise.
O.V. Dolgikh, D.G. Dianova
doaj   +1 more source

Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine [PDF]

, 2014
Peer reviewedPublisher ...
Anne-Sophie eDelbes, Celine eCansell, Francois eTronche, Frederic eAmbroggi, Frederic eAmbroggi, Jacques eBARIK, Jacques eBARIK, Marc eTuriault, Marie-Louise eDongelmans, Pier Vincenzo Piazza, Sebastien eParnaudeau, Sebastien eParnaudeau, Serge H Luquet   +12 more
core   +6 more sources

Sensitization patterns and minimum screening panels for aeroallergens in self-reported allergic rhinitis in China

Scientific Reports, 2017
Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China.
H. Lou, Siyuan Ma, Yan Zhao, F. Cao, F. He, Zhong-yan Liu, J. Bousquet, Chengshuo Wang, Luo Zhang, C. Bachert   +9 more
semanticscholar   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150 [PDF]

, 2008
Peer ...
Altier, Bautista, Bhave, Bhave, Bregman, Caterina, Caterina, Caterina, Cesare, Cesare, Chai, Chuang, Coghlan, Colledge, Darian-Smith, Davis, Distler, Docherty, Gao, Guler, Hoshi, Hoshi, Huang, Jahnel, Jordt, Jung, Klauck, Koplas, Leiser, Lin, Lin Li, Lishko, Lopshire, Lu, Lumpkin, Matta, McKemy, Morenilla-Palao, Moriyama, Navedo, Nilius, Nilius, Novakova-Tousova, Numazaki, Oliveria, Perl, Peter A. McNaughton, Prescott, Rathee, Reid, Sandoz, Smith, Smith, Southall, Stein, Story, Vellani, Venkatachalam, Voets, Watanabe, Xu, Xuming Zhang, Zhang, Zurborg   +63 more
core   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source