Results 101 to 110 of about 149,683 (183)

Simplified Protocol for the Purification of Native Cas Nucleases for DNA-Free Genome Editing. [PDF]

Methods Protoc
D'Amico M, Maggiolini FAM, Forleo LR, Cardone MF, Velasco R, Basile T, Bergamini C.   +6 more
europepmc   +1 more source

Intersectin‐1 enhances calcium‐dependent replenishment of the readily releasable pool of synaptic vesicles during development

The Journal of Physiology, EarlyView.
Abstract figure legend During development, Intersectin‐1 (Itsn1) translocates near voltage‐gated calcium channels (VGCCs) to enhance Ca2+‐dependent replenishment of readily releasable synaptic vesicles (SVs). In the presynaptic terminal, SVs undergo a cycle involving formation (step 1), docking (step 2), exocytosis (step 3), endocytosis (step 4) and ...
Yi‐Mei Yang, Adam Fekete, Jason Arsenault, Ameet S. Sengar, Jamila Aitoubah, Giovanbattista Grande, Angela Li, Eric W. Salter, Alex Wang, Melanie D. Mark, Stefan Herlitze, Sean E. Egan, Michael W. Salter, Lu‐Yang Wang   +13 more
wiley   +1 more source

Preformed mincle dimers stabilized by an interchain disulfide bond in the neck region. [PDF]

Glycobiology
Liu Y, Drickamer K, Taylor ME.
europepmc   +1 more source

The Pepper E3 Ligase CaGIR1 Acts as a Negative Regulator of Drought Response via Controlling CaGRAS1 Stability

Plant, Cell &Environment, Volume 48, Issue 7, Page 5498-5513, July 2025.
ABSTRACT The ubiquitin‐proteasome pathway modulates protein stability, which impacts plant responses to abiotic stresses, such as drought. Our previous study reported that the pepper GRAS‐type transcription factor CaGRAS1 plays a positive role in drought resistance.
Woonhee Baek, Donghyuk Oh, Lim Chae Woo, Sung Chul Lee   +3 more
wiley   +1 more source

Peptides based on the interface of hnRNPA2B1-transthyretin complex repress retinal angiogenesis in diabetic retinopathy. [PDF]

J Transl Med
Chen Y, Ye L, Cui S, Shao J, Xin Y.
europepmc   +1 more source

Calpain inhibition in a transgenic model of calpastatin overexpression facilitates reversal of myocardial hypertrophy

ESC Heart Failure, Volume 12, Issue 3, Page 2256-2266, June 2025.
Abstract Aims It was recently demonstrated that the intracellular signalling phosphatase calcineurin is subject to cleavage by the protease calpain, resulting in a truncated calcineurin fragment that is a strong inductor of myocardial hypertrophy. We now address the question of whether inhibition of calpain function in cardiomyocytes, and thereby ...
Gregor Sachse, Johanna Tennigkeit, Nikolaos Pagonas, Philipp Hillmeister, Ivo Buschmann, Martin Czolbe, Peter Nordbeck, Joachim Schmitt, Daniel Patschan, Oliver Ritter   +9 more
wiley   +1 more source

A "proto" type galectin expressed in striped bass (<i>Morone saxatilis</i>) tissues is released to epidermal mucus and binds to bacterial and mucus glycans. [PDF]

Front Cell Infect Microbiol
Henrikson DE, Ahmed H, Tasumi S, Gokara M, Feng C, Abernathy K, Iqbal M, Bianchet MA, Vasta GR.   +8 more
europepmc   +1 more source

Enolase and 16.5‐kDa Tegument‐Associated Protein in Fasciola hepatica Extracellular Vesicles: Clues to Their Role in Pathogenesis

Journal of Extracellular Biology, Volume 4, Issue 6, June 2025.
Recombinant enolase and 16.5 tegumentary proteins from F. hepatica EVs may influence the progression of fibrosis, altering cell growth, proteomic profiles, and EVs secretion in macrophages, hepatic stellate cells (HSCs) and hepatocytes. r‐Fhenolase reduced fibrosis markers in HSCs and exhibited anti‐inflammatory properties in macrophages, and r‐Fh16 ...
Aránzazu González‐Arce, Christian M. Sánchez‐López, Liz F. Sánchez‐Palencia, Antonio Marcilla, Dolores Bernal   +4 more
wiley   +1 more source

A SecA-associated protease modulates the extent of surface display of staphylococcal protein A. [PDF]

J Bacteriol
Azam MS, Ibrahim AM, Leddy O, Oh S-Y, Schneewind O, Missiakas D.   +5 more
europepmc   +1 more source

Proteomics of Urinary Extracellular Vesicles Highlight the Involvement of Vitronectin and the Fibrinolytic and TNF Pathways as Mechanisms Underlying Renal Fibrosis in Kidney Transplant Patients

Journal of Extracellular Biology, Volume 4, Issue 6, June 2025.
ABSTRACT Vitronectin (VTN) is a potential non‐invasive biomarker for renal fibrosis, originally described in urinary extracellular vesicles (uEV) from kidney transplant patients (KTx). However, VTN's specific role in renal fibrosis is unclear, as it is involved in various physiological processes.
Marta Clos‐Sansalvador, Sergio G. Garcia, Paula Rodríguez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Cristina Grange, Benedetta Bussolati, Marcella Franquesa, Javier Juega, Francesc E. Borràs   +9 more
wiley   +1 more source