Results 111 to 120 of about 149,683 (183)

Targeting LIF With Cyclovirobuxine D to Suppress Tumor Progression via LIF/p38MAPK/p62‐Modulated Mitophagy in Hepatocellular Carcinoma

MedComm, Volume 6, Issue 6, June 2025.
Multi‐omics approaches identify LIF as a potential biomarker and druggable protein that is dysregulated in HCC. LIF inhibition suppresses HCC development by inducing mitophagy via the novel LIF/p38MAPK/p62 pathway. Cyclovirobuxine‐D (CVB‐D) was identified as the first LIF inhibitor in HCC, which binding LIF at Val145, showed therapeutic potential in ...
Yingying Shao, Di Lu, Wenke Jin, Sibao Chen, Lifeng Han, Tao Wang, Leilei Fu, Haiyang Yu   +7 more
wiley   +1 more source

Protocol to culture Leishmania protozoans for lipophosphoglycan extraction and purification. [PDF]

STAR Protoc
Teufel LU, Dos Santos JC.
europepmc   +1 more source

Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva

Protein Science, Volume 34, Issue 6, June 2025.
Abstract The Theileria parva sporozoite surface antigen p67 is a target of the bovine humoral immune response that generates antibodies capable of providing protection against subsequent infection. As a result, p67 has been the subject of efforts aimed at the development of an anti‐sporozoite subunit vaccine.
Shane Miersch, Alex U. Singer, Chao Chen, Fred Fellouse, Anupriya Gopalsamy, Luciano Silva e Costa, Anna Lacasta, Hannah Chege, Naomi Chege, Vishvanath Nene, Sachdev S. Sidhu   +10 more
wiley   +1 more source

HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response. [PDF]

EMBO Rep
Nishimura S, Kioka H, Ding S, Hakui H, Shinomiya H, Tanabe K, Hitsumoto T, Matsuoka K, Kato H, Tsukamoto O, Asano Y, Takashima S, Enchev RI, Sakata Y.   +13 more
europepmc   +1 more source

Design and evolution of a synthetic small protein scaffold based on the WW domain

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Protein engineering is a powerful tool in biotechnology and the basis to create unprecedented sequences, structures, and functions. The WW domains are a family of naturally occurring proteins involved in the molecular recognition of proline‐rich and phosphorylated peptide sequences with relevance in cellular processes involved in human ...
Ana Margarida Gonçalves Carvalho Dias, Gonçalo Duarte Gomes Teixeira, Arménio Jorge Moura Barbosa, Joao Goncalves, Olga Iranzo, Ana Cecília Afonso Roque   +5 more
wiley   +1 more source

Bacteriocin from the Raccoon Dog Oral Microbiota Inhibits the Growth of Pathogenic Methicillin-Resistant Staphylococcus aureus. [PDF]

Acta Naturae
Baranova MN, Soboleva EA, Kornienko MA, Malakhova MV, Mokrushina YA, Gabibov AG, Terekhov SS, Smirnov IV.   +7 more
europepmc   +1 more source

Defining short linear motif binding determinants by phage display‐based deep mutational scanning

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Deep mutational scanning (DMS) has emerged as a powerful approach for evaluating the effects of mutations on binding or function. Here, we developed a DMS by phage display protocol to define the specificity determinants of short linear motifs (SLiMs) binding to peptide‐binding domains.
Caroline Benz, Lars Maassen, Leandro Simonetti, Filip Mihalic, Richard Lindqvist, Ifigenia Tsitsa, Aimiliani Konstantinou, Per Jemth, Anna K. Överby, Norman E. Davey, Ylva Ivarsson   +10 more
wiley   +1 more source

Overexpression and biophysical and functional characterization of a recombinant FGF21. [PDF]

Biophys Rep (N Y)
Phan P, Hoang J, Kumar TKS.
europepmc   +1 more source

Gibberellin signalling mediates nucleocytoplasmic trafficking of Sucrose Synthase 1 to regulate the drought tolerance in rice

Plant Biotechnology Journal, Volume 23, Issue 6, Page 1909-1926, June 2025.
Summary The Green Revolution (GR) has substantially improved cereal crop yields and enhanced adaptation to diverse environmental challenges. However, the molecular and cellular mechanisms involving GR‐related genes that regulate drought tolerance in plants remain largely unclear.
Jishuai Huang, Bin Xie, Fengjun Xian, Kejia Liu, Qian Yan, Yurong He, Lin Zhu, Wei Liu, Yue Jiang, Yuting Chen, Leilei Peng, Yuwei Zhou, Jun Hu   +12 more
wiley   +1 more source

Different propensities for gate opening in gyrases and topoisomerase IV. [PDF]

Nucleic Acids Res
Willing F, Mhaindarkar VP, Hirsch J, Lanz MA, Mitton-Fry MJ, Gubaev A, Klostermeier D.   +6 more
europepmc   +1 more source