Results 201 to 210 of about 240,931 (342)

Crystallographic fragment screening against SARS‐CoV‐2 nonstructural protein 1 using the F2X‐Entry Screen and a newly developed fragment library

open access: yesActa Crystallographica Section D, EarlyView.
Two crystallographic fragment screening campaigns against SARS‐CoV‐2 nonstructural protein 1 resulted in the identification of 21 new hits.Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) continues to threaten global health. This underpins the need for novel therapeutics against this virus.
Frank Lennartz   +9 more
wiley   +1 more source

Bordetella BcrH1 and BcrH2 Are Specific Chaperones for the Pore‐Forming Complex

open access: yesMicrobiology and Immunology, EarlyView.
ABSTRACT Bordetella has a type III secretion system that secretes virulence proteins crucial to the establishment of infection. The genes encoding components of the Bordetella type III secretion system are located in the bsc region on the chromosome. This region includes the bcrH1 and bcrH2 genes, which respectively encode the proteins BcrH1 and BcrH2.
Yuya Kishino   +4 more
wiley   +1 more source

Assay of Activated Form of Progesterone Receptor with ATP-Sepharose Column Chromatography

open access: diamond, 1989
Masafusa Asai   +3 more
openalex   +2 more sources

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy