Results 61 to 70 of about 149,683 (183)
Clinical and Experimental Neuroimmunology, Volume 16, Issue 2, Page 88-97, May 2025.Principle and performance of an immunoprecipitation assay for detecting anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) autoantibodies using a non‐radioactive biotinylated recombinant protein. This new assay can serve as a potential alternative to the gold standard immunoprecipitation assay for detecting anti‐anti‐3‐hydroxy‐3 ...
Yukihiro Nishikawa +8 more
wiley +1 more source
MUSTN1 Interaction With SMPX Regulates Muscle Development and Regeneration
Cell Proliferation, EarlyView.Model of the role of MUSTN1 in skeletal muscle development. MUSTN1‐KO mice display delayed muscle growth and regeneration. MUSTN1 protects SMPX from instability and maintains the morphology of muscle fibres. MUSTN1 and SMPX synergistically promote myoblast proliferation and dependently facilitate differentiation.
Yu Fu +6 more
wiley +1 more source
Identification of an exosite at the neutrophil elastase/alpha‐1‐antitrypsin interface
The FEBS Journal, Volume 292, Issue 8, Page 1887-1903, April 2025.Molecular dynamics simulations predicted an exosite in the encounter complex between alpha‐1 antitrypsin (AAT) and neutrophil elastase (NE), comprising a patch of acidic residues which interacts with a basic loop on NE. Recombinant AAT variants with mutations of the three acidic residues show reduced association rate compared to wild‐type and confirm ...
Roberto Gangemi +8 more
wiley +1 more source
The FEBS Journal, EarlyView.Enhancing endocannabinoid signaling by targeting FAAH effectively mitigates cognitive deficits, reduces amyloid pathology, and modulates neuroinflammatory responses in a preclinical model of Alzheimer's disease. This effect is potentially mediated by attenuating the Aβ‐induced overexpression of the Bace1 gene through CB1‐dependent hypermethylation of ...
Sergio Oddi +12 more
wiley +1 more source
The FEBS Journal, EarlyView.Targeting the stability of oncogenic mutant p53 (mutp53) presents a promising strategy for cancer therapy. This study identifies the deubiquitinases (DUBs) USP5 and USP9X as key regulators of mutp53 stability. The DUB inhibitor WP1130 selectively destabilized mutp53 by promoting its ubiquitination, nuclear aggregation, and degradation via the ...
Swapnil Oak +6 more
wiley +1 more source
Bacterial transcriptional repressor NrdR – a flexible multifactorial nucleotide sensor
The FEBS Journal, EarlyView.NrdR is a bacterial transcription factor that regulates the expression of all three types of ribonucleotide reductase, an essential enzyme for cell survival, in response to intracellular ATP and dATP levels. We have carried out a comprehensive biochemical, biophysical and structural study of the response of E. coli NrdR to ATP and dATP.
Inna Rozman Grinberg +9 more
wiley +1 more source
Binding of proteins to CNBr‐activated sepharose 4B [PDF]
FEBS Letters, 1974 Gary S. David +2 more
openaire +3 more sources
Spermidine reduces ISGylation and enhances ISG15-USP18 interaction. [PDF]
Sci RepEtori H, Asoshina R, Obita T, Okumura F.
europepmc +1 more source
The FEBS Journal, EarlyView.Agarose gel‐supported lipid bilayers constructed at the interface between the lipid solution and the recording solution are useful for measuring channel currents through different types of toxin pores. In this system, the lipid bilayers can be easily reconstructed even after the bilayer is disrupted, and measurements of toxin pores could be repeated ...
Tsubasa Okuda +5 more
wiley +1 more source
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases. [PDF]
Adv Sci (Weinh)Mu W +13 more
europepmc +1 more source