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Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction
Inflammation Research, 2021Sepsis-induced myocardial dysfunction (SIMD) is a condition manifested by an intrinsic myocardial systolic and diastolic dysfunction during sepsis, which is associated with worse clinical outcomes and a higher mortality.Several pathophysiological mechanisms including mitochondrial dysfunction, abnormal body immune reaction, metabolic reprogramming ...
Hang Yang, Zhaocai Zhang
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Polo-like kinase 1 promotes sepsis-induced myocardial dysfunction
International Immunopharmacology, 2023Sepsis-induced myocardial dysfunction (SIMD) is the main cause of mortality in sepsis. In this study, we identified Polo-like kinase 1 (Plk-1) is a promoter of SIMD. Plk-1 expression was increased in lipopolysaccharide (LPS)-treated mouse hearts and neonatal rat cardiomyocytes (NRCMs). Inhibition of Plk-1 either by heterozygous deletion of Plk-1 or Plk-
Yaqi Xing, Chen Chen, Yuanyuan Zheng
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SEPSIS-INDUCED MYOCARDIAL DYSFUNCTION
Shock, 2006Despite the fact that septic patients exhibit altered cardiac function, it is not considered a major pathology during sepsis. Thus, the molecular mechanisms underlying sepsis-induced myocardial dysfunction have not been studied extensively. In a polymicrobial septic rat model, +dP/dt and -dP/dt on day 1 were not altered but found depressed later, i.e.,
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Sepsis-induced myocardial dysfunction
Current Opinion in Critical Care, 2018Purpose of review Sepsis leads to a complex intramyocardial inflammatory response that results in sepsis-induced myocardial dysfunction. Here, recent findings are reviewed in a physiologic context. Recent findings Decreased systolic contractility during sepsis limits ventricular ...
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Protective effects of NLRP3 inhibitor MCC950 on sepsis-induced myocardial dysfunction
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2021Sepsis-induced myocardial dysfunction (SIMD) leads to poor prognosis or even death in severe sepsis cases, therefore, exploring its pathogenesis and new therapeutic targets has become the focus of current research. Specifically, an SIMD rat model was constructed by cecal ligation and puncture (CLP) method. At 24 h after intraperitoneal injection of the
S, Li, Z, Guo, Z Y, Zhang
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Sepsis-induced myocardial dysfunction and myocardial protection from ischemia/reperfusion injury
Frontiers in Bioscience, 2006Sepsis, bacteremia and inflammation cause myocardial depression. The mechanism of the dysfunction is not clearly established partly because dysfunction can be elicited by many different mechanisms which can all manifest in disruption of myocardial mechanical function. In addition the models of sepsis and bacteremia and inflammation may vary drastically
Kathleen H, McDonough +1 more
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Downregulation of PI3K-γ in a mouse model of sepsis-induced myocardial dysfunction
Cytokine, 2017A key component during sepsis is the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, of which the PI3K-γ isoform is a major regulator in many inflammatory responses. However, the role of PI3K-γ in the development of sepsis-induced myocardial dysfunction (SIMD) is unknown.
Ting-Ting, Fan +4 more
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Overexpression of CTRP3 protects against sepsis-induced myocardial dysfunction in mice
Molecular and Cellular Endocrinology, 2018C1q/tumor necrosis factor-related protein-3 (CTRP3) shows striking homologies of genomic structure to the adiponectin. In this study, we aimed to investigate the protective role of CTRP3 against sepsis-induced cardiomyopathy. Here, we overexpressed CTRP3 in myocardium by direct intramyocardial injection and constructed a model of lipopolysaccharide ...
Wen-Ying Wei +6 more
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[Pathogenesis of sepsis-induced myocardial dysfunction].
Zhonghua wei zhong bing ji jiu yi xue, 2018Sepsis is a common disease in intensive care units (ICU), and the resulted multi-organ dysfunction syndrome (MODS) is the main cause of death in patients with severe sepsis. The cardiovascular system is one of the most important target organ for sepsis.
Yunpeng, Lou, Zhaofen, Lin
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Interleukin-27 is elevated in sepsis-induced myocardial dysfunction and mediates inflammation
Cytokine, 2016Interleukin (IL)-27 is an important cytokine involved in many human inflammatory diseases. In this study, we investigated its role in the pathogenesis of sepsis-induced myocardial dysfunction (SIMD).Twenty patients with SIMD and 24healthy donors were prospectively enrolled. Expression of IL-27 was detected in serum from SIMD patients by ELISA.
Feng, Gao +6 more
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