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The Role of Complement System in Septic Shock
Clinical and Developmental Immunology, 2012 Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh +8 more
doaj +1 more source
Fluid balance and cardiac function in septic shock as predictors of hospital mortality [PDF]
, 2013 INTRODUCTION: Septic shock is a major cause of morbidity and mortality throughout the world. Unfortunately, the optimal fluid management of septic shock is unknown and currently is empirical.
Doherty, Joshua A +5 more
core +3 more sources
F1000 Medicine Reports, 2010 Although several successful clinical trials in the last 2-3 years have been greeted with enthusiasm by intensivists, severe sepsis and septic shock still have increasing incidence and more or less unchanged mortality. Within the last few years, the progress in sepsis research covering definitions, epidemiology, pathophysiology, diagnosis, and standard ...
Gerlach, Herwig, Toussaint, Susanne
openaire +2 more sources
Critical Care, 2020 Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rates range from 15 to 56%.
M. Bauer +5 more
semanticscholar +1 more source
Characteristics and Outcomes of Patients with Vasoplegic Versus Tissue Dysoxic Septic Shock [PDF]
, 2013 Background: The current consensus definition of septic shock requires hypotension after adequate fluid challenge or vasopressor requirement. Some patients with septic shock present with hypotension and hyperlactatemia greater than 2 mmol/L (tissue ...
Jones, Alan E +6 more
core +1 more source
Annals of Intensive Care, 2021 The autonomic nervous system (ANS) regulates the cardiovascular system. A growing body of experimental and clinical evidence confirms significant dysfunction of this regulation during sepsis and septic shock.
M. Carrara +3 more
semanticscholar +1 more source
Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions [PDF]
, 2017 Background: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods:
A Mantovani +48 more
core +1 more source
Critical Care, 2021 Background Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients.
Arianna Piotti +95 more
semanticscholar +1 more source
The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: A meta-analysis of randomized controlled trials [PDF]
, 2014 __Introduction:__ The Surviving Sepsis Campaign guidelines recommend goal-directed therapy (GDT) for the early resuscitation of patients with sepsis. However, the findings of the ProCESS (Protocolized Care for Early Septic Shock) trial showed no benefit ...
Bakker, J. (Jan) +4 more
core +7 more sources
Veterinary Clinics of North America: Small Animal Practice, 1989 Septic shock is a life-threatening condition that results from the combined effects of bacteria and the host's chemical mediators of inflammation. Of particular detriment is the hyperdynamic and hypodynamic vasomotor instability that severely compromises the patient prior to the onset of overt bacteremia.
Resident, From the Department of Small Animal Clinical Sciences, University of Florida College of Veterinary Medicine, Gainesville, Florida ( host institution ) +2 more
openaire +5 more sources