Results 31 to 40 of about 1,083,142 (408)

Comparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock [PDF]

, 2018
The Surviving Sepsis Guidelines suggest the use of vasopressin in case of catecholamine-refractory septic shock. Terlipressin (TP) as a V-1-selective AVP analogue is a potential alternative, though data regarding the first-line administration in septic ...
Arnemann, Philip H, Becker, Karsten, Ertmer, Christian, Hessler, Michael, Kampmeier, Tim G, Morelli, Andrea, Rehberg, Sebastian W, Seidel, Laura M   +7 more
core   +1 more source

Septic Shock

Journal of Anesthesia and Anesthetic Drugs, 2022
Patients who present to the emergency department demonstrating clinical signs of circulatory shock constitute a medical emergency, often associated with significant mortality. Severe sepsis, characterized as infection with systemic manifestations and accompanying organ dysfunction or tissue hypoperfusion, can lead to septic shock.
openaire   +1 more source

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Critical Care, 2020
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rates range from 15 to 56%.
M. Bauer, H. Gerlach, T. Vogelmann, F. Preissing, J. Stiefel, D. Adam   +5 more
semanticscholar   +1 more source

Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study

Critical Care, 2021
Background Timely administration of antibiotics is one of the most important interventions in reducing mortality in sepsis. However, administering antibiotics within a strict time threshold in all patients suspected with sepsis will require huge amount ...
Y. Im, D. Kang, R. Ko, Yeon Joo Lee, S. Lim, Sunghoon Park, S. J. Na, C. Chung, M. Park, D. Oh, C. Lim, G. Suh, Chae-Man Sang-Bum Dong Kyu Gee Young Kyeongman Ryoung-Eun Y Lim Hong Oh Suh Jeon Ko Cho Lee Lim Park Heo Lee K, C. Lim, Sang-Bum Hong, D. Oh, G. Suh, K. Jeon, R. Ko, Y. Cho, Yeon Joo Lee, S. Lim, Sunghoon Park, J. Heo, Jae-Myeong Lee, K. Kim, Youjin Chang, Sang-Min Lee, Suk-Kyung Hong, W. Cho, Sanghyeon Kwak, Heung Bum Lee, J. Ahn, G. Seong, Song-I Lee, T. Park, Su Hwan Lee, E. Choi, J. Moon   +38 more
semanticscholar   +1 more source

Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis

Медицинская иммунология, 2020
Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
doaj   +1 more source

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock.
T. Fujii, N. Luethi, P. Young, D. Frei, G. Eastwood, C. French, A. Deane, Y. Shehabi, L. Hajjar, G. Oliveira, A. Udy, N. Orford, S. Edney, A. Hunt, H. Judd, L. Bitker, L. Cioccari, T. Naorungroj, Fumitaka Yanase, S. Bates, F. McGain, Elizabeth P Hudson, W. Al-Bassam, D. B. Dwivedi, C. Peppin, P. Mccracken, J. Orosz, M. Bailey, R. Bellomo   +28 more
semanticscholar   +1 more source

Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock

Biomedicines, 2022
(1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death.
Jesús Beltrán-García, Rebeca Osca-Verdegal, Beatriz Jávega, Guadalupe Herrera, José-Enrique O’Connor, Eva García-López, Germán Casabó-Vallés, María Rodriguez-Gimillo, José Ferreres, Nieves Carbonell, Federico V. Pallardó, José Luis García-Giménez   +11 more
doaj   +1 more source

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study [PDF]

, 2018
Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)—a sensitive biomarker of glomerular function,
Antonelli, M., Beishuizen, A., Bergmann, A., Chousterman, B. G., Constatin, J. -M., Damoisel, C., Deye, N., Di Somma, S., Dugernier, T., Francois, B., Gaudry, S., Gayat, E., Hartmann, O., Hollinger, A., Huberlant, V., Lascarrou, J. -B., Laterre, P. -F., Legrand, M., Marx, G., Mebazaa, A., Mercier, E., Oueslati, H., Pickkers, P., Sonneville, R., Struck, J., Wittebole, X.   +25 more
core   +2 more sources

Contribution of Metabolic Cell Swelling on Microcirculatory Perfusion in Septic Shock [PDF]

, 2023
Sepsis, a systemic immunological response that leads to organ-dysfunction, the development of septic shock, and death has mortality rate of 15-25%. A subset of sepsis, septic shock, has an in-hospital mortality rate of 30-50%.
Payne, Charles E
core   +2 more sources

The Role of Complement System in Septic Shock

Clinical and Developmental Immunology, 2012
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang   +8 more
doaj   +1 more source