Results 31 to 40 of about 1,095,165 (407)

Comparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock [PDF]

, 2018
The Surviving Sepsis Guidelines suggest the use of vasopressin in case of catecholamine-refractory septic shock. Terlipressin (TP) as a V-1-selective AVP analogue is a potential alternative, though data regarding the first-line administration in septic ...
Arnemann, Philip H, Becker, Karsten, Ertmer, Christian, Hessler, Michael, Kampmeier, Tim G, Morelli, Andrea, Rehberg, Sebastian W, Seidel, Laura M   +7 more
core   +1 more source

Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis

Медицинская иммунология, 2020
Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
doaj   +1 more source

A model of porcine polymicrobial septic shock

Intensive Care Medicine Experimental, 2023
Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Mortality of patients with sepsis is high and largely unchanged throughout the past decades.
Finnja Marie Zurek-Leffers, Florian Lehmann, Laura Brabenec, Sebastian Kintrup, Katharina E. M. Hellenthal, Kira Mersjann, Felicia Kneifel, Michael Hessler, Philip-Helge Arnemann, Tim-Gerald Kampmeier, Christian Ertmer, Patrick Kellner, Nana-Maria Wagner   +12 more
doaj   +1 more source

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Critical Care, 2020
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rates range from 15 to 56%.
M. Bauer, H. Gerlach, T. Vogelmann, F. Preissing, J. Stiefel, D. Adam   +5 more
semanticscholar   +1 more source

Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study

Critical Care, 2021
Background Timely administration of antibiotics is one of the most important interventions in reducing mortality in sepsis. However, administering antibiotics within a strict time threshold in all patients suspected with sepsis will require huge amount ...
Y. Im, D. Kang, R. Ko, Yeon Joo Lee, S. Lim, Sunghoon Park, S. J. Na, C. Chung, M. Park, D. Oh, C. Lim, G. Suh, Chae-Man Sang-Bum Dong Kyu Gee Young Kyeongman Ryoung-Eun Y Lim Hong Oh Suh Jeon Ko Cho Lee Lim Park Heo Lee K, C. Lim, Sang-Bum Hong, D. Oh, G. Suh, K. Jeon, R. Ko, Y. Cho, Yeon Joo Lee, S. Lim, Sunghoon Park, J. Heo, Jae-Myeong Lee, K. Kim, Youjin Chang, Sang-Min Lee, Suk-Kyung Hong, W. Cho, Sanghyeon Kwak, Heung Bum Lee, J. Ahn, G. Seong, Song-I Lee, T. Park, Su Hwan Lee, E. Choi, J. Moon   +38 more
semanticscholar   +1 more source

Augmented renal clearance is not a risk factor for mortality in Enterobacteriaceae bloodstream infections treated with appropriate empiric antimicrobials [PDF]

, 2017
The main objective of the study was to assess whether augmented renal clearance was a risk factor for mortality in a cohort of patients with Enterobacteriaceae sepsis, severe sepsis, or septic shock that all received appropriate antimicrobial therapy ...
Burnham, Jason P, Kollef, Marin H, Micek, Scott T   +2 more
core   +10 more sources

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock.
T. Fujii, N. Luethi, P. Young, D. Frei, G. Eastwood, C. French, A. Deane, Y. Shehabi, L. Hajjar, G. Oliveira, A. Udy, N. Orford, S. Edney, A. Hunt, H. Judd, L. Bitker, L. Cioccari, T. Naorungroj, Fumitaka Yanase, S. Bates, F. McGain, Elizabeth P Hudson, W. Al-Bassam, D. B. Dwivedi, C. Peppin, P. Mccracken, J. Orosz, M. Bailey, R. Bellomo   +28 more
semanticscholar   +1 more source

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study [PDF]

, 2018
Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)—a sensitive biomarker of glomerular function,
Antonelli, M., Beishuizen, A., Bergmann, A., Chousterman, B. G., Constatin, J. -M., Damoisel, C., Deye, N., Di Somma, S., Dugernier, T., Francois, B., Gaudry, S., Gayat, E., Hartmann, O., Hollinger, A., Huberlant, V., Lascarrou, J. -B., Laterre, P. -F., Legrand, M., Marx, G., Mebazaa, A., Mercier, E., Oueslati, H., Pickkers, P., Sonneville, R., Struck, J., Wittebole, X.   +25 more
core   +2 more sources

Q fever outbreak in the terraced vineyards of Lavaux, Switzerland

New Microbes and New Infections, EarlyView., 2014
Abstract Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux ...
C. Bellini, I. Magouras, C. Chapuis‐Taillard, O. Clerc, E. Masserey, G. Peduto, O. Péter, S. Schaerrer, G. Schuepbach, G. Greub   +9 more
wiley   +1 more source

The Role of Complement System in Septic Shock

Clinical and Developmental Immunology, 2012
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang   +8 more
doaj   +1 more source