Results 31 to 40 of about 1,087,361 (389)

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Critical Care, 2020
Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality risks. Consequently, mortality rates range from 15 to 56%.
M. Bauer, H. Gerlach, T. Vogelmann, F. Preissing, J. Stiefel, D. Adam   +5 more
semanticscholar   +1 more source

Septic shock: perspective methods of diagnostics and therapy based on immunopathogenesis

Медицинская иммунология, 2020
Based on the III International Consensus on the definition of Sepsis and Septic Shock (Sepsis-3), the modern definition of septic shock was proposed: “Septic shock is a type of sepsis that is accompanied by severe hemodynamic, metabolic and cellular ...
L. I. Gomanova
doaj   +1 more source

Characterization of Early Peripheral Immune Responses in Patients with Sepsis and Septic Shock

Biomedicines, 2022
(1) Background: Sepsis is a life-threatening condition caused by an abnormal host response to infection that produces altered physiological responses causing tissue damage and can result in organ dysfunction and, in some cases, death.
Jesús Beltrán-García, Rebeca Osca-Verdegal, Beatriz Jávega, Guadalupe Herrera, José-Enrique O’Connor, Eva García-López, Germán Casabó-Vallés, María Rodriguez-Gimillo, José Ferreres, Nieves Carbonell, Federico V. Pallardó, José Luis García-Giménez   +11 more
doaj   +1 more source

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock.
T. Fujii, N. Luethi, P. Young, D. Frei, G. Eastwood, C. French, A. Deane, Y. Shehabi, L. Hajjar, G. Oliveira, A. Udy, N. Orford, S. Edney, A. Hunt, H. Judd, L. Bitker, L. Cioccari, T. Naorungroj, Fumitaka Yanase, S. Bates, F. McGain, Elizabeth P Hudson, W. Al-Bassam, D. B. Dwivedi, C. Peppin, P. Mccracken, J. Orosz, M. Bailey, R. Bellomo   +28 more
semanticscholar   +1 more source

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study [PDF]

, 2018
Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)—a sensitive biomarker of glomerular function,
Antonelli, M., Beishuizen, A., Bergmann, A., Chousterman, B. G., Constatin, J. -M., Damoisel, C., Deye, N., Di Somma, S., Dugernier, T., Francois, B., Gaudry, S., Gayat, E., Hartmann, O., Hollinger, A., Huberlant, V., Lascarrou, J. -B., Laterre, P. -F., Legrand, M., Marx, G., Mebazaa, A., Mercier, E., Oueslati, H., Pickkers, P., Sonneville, R., Struck, J., Wittebole, X.   +25 more
core   +2 more sources

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock [PDF]

, 2005
Stress doses of hydrocortisone a re known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the
Anderson, Annane, Astudillo, Barie, Barie, Bastos, Bertsch, Blomquist, Bollaert, Bolton, Bolton, Bone, Briegel, Briegel, Briegel, Briegel, Danielson, Donato, Eidelman, Endo, Haimoto, Herrmann, Hollenberg, Hund, Hund, Jonsson, Keh, Lindner, Marshall, Metinko, Munck, Mussack, Mussack, Pelinka, Pelinka, Rosen, Schwarz, Stanimirovic, Usui, Vincent, Waage, Weiss, Westaby, Wheeler, Wiesmann, Wunderlich, Young   +46 more
core   +2 more sources

The Role of Complement System in Septic Shock

Clinical and Developmental Immunology, 2012
Septic shock is a critical clinical condition with a high mortality rate. A better understanding of the underlying mechanisms is important to develop effective therapies.
Jean Charchaflieh, Jiandong Wei, Georges Labaze, Yunfang Joan Hou, Benjamin Babarsh, Helen Stutz, Haekyung Lee, Samrat Worah, Ming Zhang   +8 more
doaj   +1 more source

Fluid balance and cardiac function in septic shock as predictors of hospital mortality [PDF]

, 2013
INTRODUCTION: Septic shock is a major cause of morbidity and mortality throughout the world. Unfortunately, the optimal fluid management of septic shock is unknown and currently is empirical.
Doherty, Joshua A, Hampton, Nicholas, Kollef, Marin H, McEvoy, Colleen, McKenzie, Matthew, Micek, Scott T   +5 more
core   +3 more sources

Changes in Circulating Procalcitonin Versus C-Reactive Protein in Predicting Evolution of Infectious Disease in Febrile, Critically Ill Patients [PDF]

, 2013
Objective:Although absolute values for C-reactive protein (CRP) and procalcitonin (PCT) are well known to predict sepsis in the critically ill, it remains unclear how changes in CRP and PCT compare in predicting evolution of: infectious disease ...
Groeneveld, A.B.J. (Johan), Hoeboer, S.H. (Sandra)   +1 more
core   +10 more sources

Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Journal of the American Medical Association (JAMA), 2016
IMPORTANCE The Third International Consensus Definitions Task Force defined sepsis as "life-threatening organ dysfunction due to a dysregulated host response to infection." The performance of clinical criteria for this sepsis definition is unknown ...
C. Seymour, V. Liu, T. Iwashyna, F. Brunkhorst, T. Rea, A. Scherag, G. Rubenfeld, J. Kahn, M. Shankar-Hari, M. Singer, C. Deutschman, G. Escobar, D. Angus   +12 more
semanticscholar   +1 more source