Results 71 to 80 of about 997,918 (264)

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Corticosteroids in septic shock: a systematic review and network meta-analysis [PDF]

, 2017
Ben Gibbison, José A López-López, Julian P. T. Higgins, Tom Miller, Gianni D. Angelini, Stafford L. Lightman, Djillali Annane   +6 more
openalex   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock [PDF]

, 2008
Andreas Link, Simina Selejan, Christoph Maack, Monika Lenz, Michael Böhm   +4 more
openalex   +1 more source

Dynamic Arginine Methylation of YBX1 Relay Controls Its Phase Separation and Chemoradiotherapy Resistance in Rectal Cancer

Advanced Science, EarlyView.
Protein arginine methyltransferase 3 (PRMT3) induces the arginine methylation of Y‐box binding protein 1 (YBX1), which suppresses phase separation and is imperative for its nuclear translocation. Subsequently, lysine‐specific demethylase 4A demethylates YBX1 to unmask the R247 residue and promote its phase separation, which transcriptionally regulates ...
Yunxing Shi, Taixuan Wan, Shaoru Liu, Huashan Liu, Ziwei Zeng, Wenxin Li, Zhenxing Liang, Li Xiong, Shuanglin Luo, Yunfei Yuan, Liang Huang, Liang Kang   +11 more
wiley   +1 more source

Fluid resuscitation in severe sepsis and septic shock: systematic description of fluids used in randomized trials [PDF]

, 2013
Bram Rochwerg, Anna Włudarczyk, Wojciech Szczeklik, Waleed Alhazzani, Anees Sindi, Fayez Alshamsi, Wang-chun Ip, Michael T.M. Wang, Sultan Altayyar, Guowei Li, Alison Fox‐Robichaud, and the FISSH group Gordon Guyatt   +11 more
openalex   +1 more source

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

Journal of the American Medical Association (JAMA), 2016
M. Shankar-Hari, Gary S. Phillips, M. Levy, C. Seymour, Vincent X. Liu, C. Deutschman, D. Angus, G. Rubenfeld, M. Singer   +8 more
semanticscholar   +1 more source

Chloroplast Fibrillin‐Mediated α‐Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance

Advanced Science, EarlyView.
ToCV‐encoded p22 targets chloroplast plastoglobules (PGs) via directly binding PG structural protein FBN1.1, reducing the size of PG and inhibiting α‐tocopherol biosynthesis via competing with tocopherol cyclase (VTE1). Consequently, the elevated chloroplast ROS not only creates a suitable cellular environment for efficient ToCV infection but also ...
Sijia Liu, Xuedong Liu, Qin Yan, Xi Chen, Lianyi Zang, Jingang Hu, Xiaoping Zhu, Zaifeng Fan, Tao Zhou   +8 more
wiley   +1 more source

Protocol-Based Resuscitation for Septic Shock: A Meta-Analysis of Randomized Trials and Observational Studies [PDF]

, 2016
Woo Kyung Lee, Ha Yeon Kim, Jinae Lee, Shin Ok Koh, Jeongmin Kim, Sungwon Na   +5 more
openalex   +1 more source

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Intensive Care Medicine, 2017
A. Rhodes, Laura Evans, W. Alhazzani, Mitchell M. Levy, M. Antonelli, R. Ferrer, Anand Kumar, J. Sevransky, L. Charles, Sprung, M. Nunnally, B. Rochwerg, G. D. Rubenfeld, D. Angus, D. Annane, Richard Beale, Geoffrey J. Bellinghan, Gordon R. Bernard, J. Chiche, C. Coopersmith, D. D. Backer, Craig French, Seitaro, Fujishima, H. Gerlach, Jorge Hidalgo, S. M. Hollenberg, Alan E. Jones, Dilip R. Karnad, R. Kleinpell, Y. Koh, T. Lisboa, R. Flavia, Machado, John J. Marini, John C. Marshall, J. Mazuski, L. McIntyre, Anthony S. McLean, S. Mehta, Rui Moreno, J. Myburgh, P. Navalesi, O. Nishida, Tiffany M. Osborn, A. Perner, Colleen M. Plunkett, Marco, Ranieri, Christa A. Schorr, Maureen A. Seckel, Christopher W. Seymour, L. Shieh, Khalid A. Shukri, Steven Q. Simpson, M. Singer, B. T. Thompson, R. Sean, Townsend, T. V. D. Poll, Jean-Louis Vincent, W. Wiersinga, L. Janice, Zimmerman, R. Dellinger   +64 more
semanticscholar   +1 more source