Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng +20 more
wiley +1 more source
A transmission relationship investigation of HIV infection through male-to-male sex among a case of left-behind children with heterosexual orientation in Zhejiang Province of China. [PDF]
Hou Z +7 more
europepmc +1 more source
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu +8 more
wiley +1 more source
A circovirus-like genomic sequence with unique architecture and phylogenetic relatedness to human-linked viral lineages. [PDF]
Dai L +11 more
europepmc +1 more source
Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates
This review highlights the construction of AIE active bioconjugates via click chemical or bioorthogonal reactions, and their applications in biosensing, bioimaging, and image‐guided treatment. The challenges and perspectives in the area are also discussed.
Xinzhe Yang +3 more
wiley +1 more source
Identification of A Novel Human Adenovirus Type 114 Associated with An Acute Respiratory Disease Outbreak at An Elementary School - Beijing, China, September 2024. [PDF]
Wei X +6 more
europepmc +1 more source
Ontogenetic sequences in phyllopharyngean ciliates. ABSTRACT Heterochronic shifts in developmental sequences of unicellular organisms are rarely considered as mechanisms behind their morphological evolution. Among eukaryotic microbes, ciliates represent a key model group, exhibiting diverse morphologies and developmental trajectories.
Klára Bukovinská, Peter Vďačný
wiley +1 more source
Predicting protein-nucleic acid flexibility using persistent sheaf Laplacians.
Hayes N, Merkurjev E, Wei GW.
europepmc +1 more source
Detection of <i>Metschnikowia bicuspidata</i> in Chinese Mitten Crabs (<i>Eriocheir sinensis</i>) Using Recombinase Polymerase Amplification. [PDF]
Liu L +6 more
europepmc +1 more source
Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu +9 more
wiley +1 more source

