Results 161 to 170 of about 21,246,065 (185)
Some of the next articles are maybe not open access.
Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma
Expert Opinion on Therapeutic Targets, 2019Protein sequestosome 1/p62 (p62) plays a crucial role in vital complex and interacting signaling pathways in normal and neoplastic cells. P62 is involved in autophagy, defense against oxidative stress via activation of the Keap1/Nrf2 system, in protein aggregation and sequestration, and in apoptosis.
Helmut Denk +3 more
openaire +2 more sources
Characterization and chemical modulation of p62/SQSTM1/Sequestosome-1 as an autophagic N-recognin
2023In the Arg/N-degron pathway, single N-terminal (Nt) residues function as N-degrons recognized by UBR box-containing N-recognins that induce substrate ubiquitination and proteasomal degradation. Recent studies led to the discovery of the autophagic Arg/N-degron pathway, in which the autophagic receptor p62/SQSTM1/Sequestosome-1 acts as an N-recognin ...
Su Jin, Lee +5 more
openaire +2 more sources
Autophagy upregulation ameliorates cell injury in Sequestosome 1 knockout podocytes in vitro
Biochemical and Biophysical Research Communications, 2017Autophagy is a catabolic process to maintain intracellular homeostasis that degrades damaged proteins and organelles in mammalian cells. Podocytes are crucial for maintaining the normal function of the glomerular filtration barrier. In the present study, we aimed to investigate the high glucose-induced cell injury in human podocytes and the protective ...
Zhaoping, Li +5 more
openaire +2 more sources
Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD)
2015p62/sequestosome-1 is a multidimensional protein that interacts with many signaling factors, and regulates a variety of cellular functions including inflammation, apoptosis, and autophagy. Our previous work has revealed in the retinal pigment epithelium (RPE) that p62 promotes autophagy and simultaneously enhances an Nrf2-mediated antioxidant response ...
Lei, Wang +4 more
openaire +2 more sources
Sequestosome 1 (SQSTM1) Mutations in Paget’s Disease of Bone from the United States
Calcified Tissue International, 2008Paget's disease of bone (PDB) is a localized bone disease characterized by excessive bone resorption due to overactive osteoclasts. Seven genetic loci (PDB1-PDB7) have been reported for late-onset PDB. PDB3 is the only locus where a gene, sequestosome 1 (SQSTM1), has been identified.
Emily C, Rhodes +10 more
openaire +2 more sources
Sequestosome 1/p62: a multi-domain protein with multi-faceted functions
Frontiers in Biology, 2012The Sequestosome 1/p62 protein has been implicated in the regulation of a multitude of cellular processes such as NF-κB signaling, NRF2-driven oxidative stress response, protein turnover through the ubiquitin-proteasome pathway and the autophagosome/lysosome pathway, apoptosis and cellular metabolism.
Xiaoyan Liu, Jozsef Gal, Haining Zhu
openaire +1 more source
Journal of Agricultural and Food Chemistry
Bacillus thuringiensis produces insecticidal crystal (Cry) proteins that target and destroy insect pest midgut epithelial cells, ultimately leading to larval death. However, exposure to sublethal concentrations of Cry proteins can activate defense responses to counteract toxicity.
Sirui Li +8 more
openaire +2 more sources
Bacillus thuringiensis produces insecticidal crystal (Cry) proteins that target and destroy insect pest midgut epithelial cells, ultimately leading to larval death. However, exposure to sublethal concentrations of Cry proteins can activate defense responses to counteract toxicity.
Sirui Li +8 more
openaire +2 more sources
Mutations in Sequestosome-1 result in inclusion body formation
Bone, 2012E. Azzam, M.H. Helfrich, L.J. Hocking⁎
openaire +1 more source