Results 141 to 150 of about 57,370,564 (168)

Regulation of the autophagy-marker Sequestosome 1 in periodontal cells and tissues by biomechanical loading

Journal of Orofacial Orthopedics, 2019
Andreas Jäger
exaly   +2 more sources

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Lnc‐MEG3 inhibits invasion, migration, and epithelial– mesenchymal transition of nasopharyngeal carcinoma cells by regulating sequestosome 1

Head and Neck, 2021
Long non‐coding RNAs regulate malignant behaviors of nasopharyngeal carcinoma (NPC). We aim to investigate the roles and mechanisms of long non‐coding RNA maternally expressed gene 3 (lnc‐MEG3) in NPC.
Cai-Feng Zhou, Huiling Cao, Xinyuan Meng, Qi-Yao Zhang   +3 more
semanticscholar   +1 more source

Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice

Journal of Biological Chemistry, 2016
Xenobiotics exposure increases endoplasmic reticulum (ER) proliferation and cytochrome P-450 (CYP) induction to sustain metabolic requirements. Whether autophagy is essential for the removal of excess ER and CYP and whether an autophagy receptor is ...
Jia Fan, Kurt Zatloukal, Leopold Frohlich   +2 more
exaly   +2 more sources

Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 2.

Biochemical and Biophysical Research Communications - BBRC, 2020
Sequestosome 1 (p62) is a multifunctional adapter protein involved in various physiological functions, such as selective autophagy and oxidative stress response.
Ayuka Yokota, M. Hiramoto, Hirotsugu Hino, Mayumi Tokuhisa, M. Miyazaki, Hiromi Kazama, Naoharu Takano, K. Miyazawa   +7 more
semanticscholar   +1 more source

Homozygous sequestosome 1 (SQSTM1) mutation: a rare cause for childhood-onset progressive cerebellar ataxia with vertical gaze palsy

Ophthalmic Genetics, 2019
Mutations in sequestosome 1 (SQSTM1) gene are associated with neurodegenerative diseases, such as frontotemporal dementia and amyotrophic lateral sclerosis.
Sruthi S Nair, Soumya Sundaram, Ramshekhar N Menon   +2 more
exaly   +2 more sources

p62/sequestosome 1 deficiency accelerates osteoclastogenesis in vitro and leads to Paget’s disease–like bone phenotypes in mice

Journal of Biological Chemistry, 2018
The sequestosome 1 gene encodes the p62 protein and is the major genetic risk factor associated with Paget's disease of bone. In 2004, p62 was reported to up-regulate osteoclast differentiation by activating the transcription factors Nfatc1 and NF-κB ...
André Gessner
exaly   +2 more sources

Oroxylin A attenuates psoriasiform skin inflammation by direct targeting p62 (sequestosome 1) via suppressing M1 macrophage polarization

British Journal of Pharmacology
Psoriasis results from the interplay of innate and adaptive immunity in the skin. Oroxylin A (OA) has shown anti‐inflammatory effects in various disorders.
Yuxiang Ma, Yun-Yao Liu, You Zhong, Xiang-Zheng Li, Yu-Jiao Xu, Le-Yi Chen, Li-Tong Gong, He Huang, Xu Chen, Yuan He, Lei Qiang   +10 more
semanticscholar   +1 more source

Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma

Expert opinion on therapeutic targets, 2019
Introduction: Protein sequestosome 1/p62 (p62) plays a crucial role in vital complex and interacting signaling pathways in normal and neoplastic cells. P62 is involved in autophagy, defense against oxidative stress via activation of the Keap1/Nrf2 system,
H. Denk, C. Stumptner, P. Abuja, K. Zatloukal   +3 more
semanticscholar   +1 more source

Molecular modelling and dynamic simulations of sequestosome 1 (SQSTM1) missense mutations linked to Paget disease of bone

Journal of Biomolecular Structure and Dynamics, 2020
The Paget disease (PDB; OMIM is 167250) is a chronic bone disease caused by pathogenic mutations in Sequestome1/p62 (SQSTM1) gene. This study has aimed to interpret the relationship of PDB linked SQSTM1 mutations with protein structure and its molecular ...
N. A. Shaik, Khalidah K Nasser, M. Alruwaili, S. R. Alallasi, R. Elango, B. Banaganapalli   +5 more
semanticscholar   +1 more source

PB1 Domain Interaction of p62/Sequestosome 1 and MEKK3 Regulates NF-κB Activation [PDF]

Journal of Biological Chemistry, 2010
p62/Sequestosome 1 is a scaffold protein involved in the regulation of autophagy, trafficking of proteins to the proteasome, and activation of NF-κB. p62 encodes an N-terminal PB1 domain in addition to the ZZ domain, TRAF6-binding domain, LC3 interaction
David Siderovski, Adam J Kimple
exaly   +2 more sources