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Sequestosome 1 Is Part of the Interaction Network of VAPB [PDF]

International Journal of Molecular Sciences, 2021
VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored membrane protein of the endoplasmic reticulum that can also be detected at the inner nuclear membrane.
Christof Lenz, Christina James, Henning Urlaub   +2 more
exaly   +4 more sources

Sequestosome 1/p62 enhances chronic skin inflammation

Journal of Allergy and Clinical Immunology, 2021
BACKGROUND The molecular control of inflammation and epidermal thickening in skin lesions of patients with Atopic Dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of ...
Peter Petzelbauer, Erwin F Wagner, Özge Uluçkan   +2 more
exaly   +3 more sources

The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence

F1000Research, 2023
Sequestosome-1, encoded by the gene SQSTM1, functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways.
Carl Laflamme, Peter McPherson, Riham Ayoubi   +2 more
exaly   +2 more sources

TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1

Molecular Immunology, 2014
The atypical protein kinase C-interacting protein p62/sequestosome-1 (p62) has emerged as a crucial molecule in a variety of cellular functions due to its involvement in various signaling mechanisms.
Carla Reale, Romania Stilo, Angela Ferravante   +2 more
exaly   +2 more sources

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Enhancing Efficacy of Albumin-Bound Paclitaxel for Human Lung and Colorectal Cancers through Autophagy Receptor Sequestosome 1 (SQSTM1)/p62-Mediated Nanodrug Delivery and Cancer therapy.

ACS Nano, 2023
Selective autophagy is a defense mechanism by which foreign pathogens and abnormal substances are processed to maintain cellular homeostasis. Sequestosome 1 (SQSTM1)/p62, a vital selective autophagy receptor, recruits ubiquitinated cargo to form ...
Yu-Wei Lin, T. Lin, Chien-Hung Chen, Roujun Wang, Ya-Hui Lin, Tzu-Yen Tseng, Yan-Jun Zhuang, Sheng Tang, Yen-Cheng Lin, Jiun-Yu Pang, Rajan Deepan Chakravarthy, Hsin-Chieh Lin, Shey-Cherng Tzou, Jui-I Chao   +13 more
semanticscholar   +1 more source

Caveolin-1 Alleviates Crohn's Disease-induced Intestinal Fibrosis by Inhibiting Fibroblasts Autophagy Through Modulating Sequestosome 1.

Inflammatory Bowel Diseases, 2022
BACKGROUND Intestinal fibrosis is a common complication of Crohn's disease (CD) and is characterized by the excessive accumulation of extracellular matrix produced by activated myofibroblasts. Caveolin-1 (CAV1) inhibits fibrosis.
Meng-Li Yu, Wei Zhu, Jin-Hai Wang, Xue-Yang Chen, Xinjue He, Bingru Lin, Li Cen, Tianyu Zhou, Chao Lu, Chao-Hui Yu, Jing Sun   +10 more
semanticscholar   +1 more source