Results 111 to 120 of about 21,246,065 (185)

Moxibustion improves cardiac function by up-regulating autophagy-related proteins of cardiomyocytes in rats with chronic heart failure

针刺研究, 2019
Objective To observe the effect of moxibustion on cardiac function and the expression of autophagy-related proteins microtubule-associated protein 1 light chain 3(LC3)and selective autophagy receptor signaling adaptor sequestosome 1(SQSTM1/p62)in rats ...
LIU Na-na, JIA Xue-zhao, WANG Jing, ZHU Guo-qi, LI Dan, LI Qing-ling, MA Qiang   +6 more
doaj  

Palmitic acid-triggered B7H3 palmitoylation promotes immune escape

Nature Communications
Colorectal cancer responds poorly to immune checkpoint blockade in most patients with microsatellite-stable (MSS) tumors, highlighting the need for alternative targets.
Zejun Rao, Changsheng Huang, Qi Wu, Mao Li, Anyi Liu, Tong Zhu, Wangshuo Yang, Lanlan Yin, Shengyu Zhu, Xiaowei She, Chengxin Yu, Lang Liu, Pengcheng Li, Yucong Bai, Dongjing Zhang, Tianci Xie, Xiang Liu, Lu Liu, Feng Xu, Guihua Wang, Junbo Hu, Xuelai Luo   +21 more
doaj   +1 more source

Targeted delivery of glucocerebrosidase to lysosomes: The LYSOTAC (LYSOsome-TArgeting Chimera) technology

Asian Journal of Pharmaceutical Sciences
Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders caused by misfolding of lysosomal proteins and their degradation via endoplasmic reticulum-associated degradation (ERAD).
Hee-Yeon Kim, Eun Nam Choi, Gee Eun Lee, Sanghwa Yoon, Su Ran Mun, Eui Jung Jung, Minji Kim, Hyomin Lim, Yang Jae Kang, Woo-Jae Park, Yong Tae Kwon, Joo-Won Park   +11 more
doaj   +1 more source

Laetiporus sulphureus polysaccharides ameliorate chronic alcoholic liver disease by activating p62/Nrf2, AMPK pathways and reshaping gut microbiota

Food Science and Human Wellness
One novel enzymatic-extractable polysaccharide (ES1) from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.
Huajie Zhao, Liang Liu, Ningning Liu, Baoguo Deng, Min Li, Duan Li, Le Jia, Ge Wang, Fan Yang   +8 more
doaj   +1 more source

Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson's disease. [PDF]

Glia, 2023
Rocha SM, Kirkley KS, Chatterjee D, Aboellail TA, Smeyne RJ, Tjalkens RB.   +5 more
europepmc   +1 more source

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. [PDF]

J Neuropathol Exp Neurol, 2020
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Prokop S, Dickson DW, Yachnis AT, Giasson BI.   +6 more
europepmc   +1 more source

Sequestosome-1 (p62) expression reveals chaperone-assisted selective autophagy in immune-mediated necrotizing myopathies. [PDF]

Brain Pathol, 2020
Fischer N, Preuße C, Radke J, Pehl D, Allenbach Y, Schneider U, Feist E, von Casteleyn V, Hahn K, Ruck T, Meuth SG, Goebel HH, Graf R, Mammen A, Benveniste O, Stenzel W.   +15 more
europepmc   +1 more source

NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1. [PDF]

J Biol Chem, 2020
Shrestha BK, Skytte Rasmussen M, Abudu YP, Bruun JA, Larsen KB, Alemu EA, Sjøttem E, Lamark T, Johansen T.   +8 more
europepmc   +1 more source

Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2. [PDF]

Cardiovasc Res
Ghosh R, Fatahian AN, Rouzbehani OMT, Hathaway MA, Mosleh T, Vinod V, Vowles S, Stephens SL, Chung SD, Cao ID, Jonnavithula A, Symons JD, Boudina S.   +12 more
europepmc   +1 more source

SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination. [PDF]

Autophagy, 2018
Yang J, Peng H, Xu Y, Xie X, Hu R.
europepmc   +1 more source