Results 101 to 110 of about 21,246,065 (185)

Successful Conversion Surgery after Ceritinib Monotherapy in a Patient with Advanced Inflammatory Myofibroblastic Tumor Harboring SQSTM1-ALK fusion

Journal of Cancer Research and Practice
Inflammatory myofibroblastic tumor (IMT) is an intermediate malignant neoplasm, and approximately 50% of patients are anaplastic lymphoma kinase positive (ALK+). Given this unique trait, ALK tyrosine kinase inhibitors (TKIs), initially developed for ALK+
Qi-An Wang, Chao-Wei Lee, Ren-Chin Wu, Chiao-En Wu   +3 more
doaj   +1 more source

NSUN2-Mediated M5c Dysregulation Promotes OSCC Ferroptosis

International Dental Journal
Aim or purpose: This study aimed to investigate the role of NSUN2-mediated 5-methylcytosine (m5C) methylation in regulating ferroptosis resistance and tumor progression in oral squamous cell carcinoma (OSCC), identifying potential epitranscriptomic ...
Yunyang Lu, Wei Zhao, Fangyang Shi, Jie Wu, Hui Gao, Hui Zhang, Jiajun Hu, Shiyu Lv, Weidong Du, Runze Li   +9 more
doaj   +1 more source

The multifaceted role of SQSTM1/p62 in disc degeneration: A master regulator of cellular stress responses

Biochemistry and Biophysics Reports
Intervertebral disc degeneration (IDD) is a key contributor to lumbar degenerative diseases and chronic low back pain. Accumulating evidence indicates that Sequestosome 1 (SQSTM1/p62), a multifunctional adaptor protein, plays a pivotal role in IDD ...
Yang Hou, Lei Liu, Tianyi Zhao, Yongfei Guo, Jiangang Shi   +4 more
doaj   +1 more source

MiR-646 inhibited cell proliferation and migration by targeting P62 in glioma

Cell Adhesion & Migration
MiR-646, a small non-coding RNA, poorly expressed in a variety of tumors. This study aimed to clarify the role of miR-646 and its underlying mechanisms in glioblastoma (GBM).
Fangyu Ye, Heng Zhang, Qianqian Chen, Yanping Gui, Geng Tian, Yuting Ye, Xin Chen, Haijuan Dong, Xiangshan Fan, Jun Chen, RuiYing Yuan, Li Zhao, Juping Yu   +12 more
doaj   +1 more source

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis. [PDF]

Mol Neurobiol, 2023
Davidson JM, Wu SSL, Rayner SL, Cheng F, Duncan K, Russo C, Newbery M, Ding K, Scherer NM, Balez R, García-Redondo A, Rábano A, Rosa-Fernandes L, Ooi L, Williams KL, Morsch M, Blair IP, Di Ieva A, Yang S, Chung RS, Lee A.   +20 more
europepmc   +1 more source

Electroacupuncture pretreatment alleviated cerebral ischemia-reperfusion injury via suppressing autophagy in cerebral cortex tissue in rats

针刺研究, 2019
ObjectiveTo investigate the effect of electroacupuncture(EA)preconditioning on autophagy in cerebral cortex tissues of rats with cerebral ischemia-reperfusion injury(CIRI),so as to explore its mechanisms underlying improvement of CIRI.MethodsThirty-three
HUANG Ya-guang, YANG Song-bai, DU Li-peng, CAI San-jin, FENG Zhi-tao, MEI Zhi-gang   +5 more
doaj  

Immunoexpression of p62/SQSTM1/Sequestosome-1 in human primary and recurrent IDH1/2 wild-type glioblastoma: A pilot study. [PDF]

Oncol Lett, 2022
Ieni A, Pizzimenti C, Broggi G, Caltabiano R, Germanò A, Barbagallo GMV, Vigneri P, Giuffrè G, Tuccari G.   +8 more
europepmc   +1 more source

Sequestosome 1-P62 : a new promoter of melanoma progression. [PDF]

, 2013
Melanoma is an extremely aggressive type of cancer, whose incidence continues to increase worldwide. Despite of new recently approved therapies, melanoma remains highly resistant to treatment and relapses are frequently seen in clinical practice. Thus, the identification of new mechanisms of melanoma progression and translation of this knowledge ...
openaire   +1 more source

Constitutive Activation of p62/Sequestosome-1-Mediated Proteaphagy Regulates Proteolysis and Impairs Cell Death in Bortezomib-Resistant Mantle Cell Lymphoma. [PDF]

Cancers (Basel), 2022
Quinet G, Xolalpa W, Reyes-Garau D, Profitós-Pelejà N, Azkargorta M, Ceccato L, Gonzalez-Santamarta M, Marsal M, Andilla J, Aillet F, Bosch F, Elortza F, Loza-Alvarez P, Sola B, Coux O, Matthiesen R, Roué G, Rodriguez MS.   +17 more
europepmc   +1 more source

Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression. [PDF]

Cell Biosci, 2021
Yuan X, Tian GG, Pei X, Hu X, Wu J.
europepmc   +1 more source