Results 91 to 100 of about 57,370,564 (168)
Food Frontiers, Volume 7, Issue 5, September 2026.Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi +6 more
wiley +1 more source
Acta Neuropathologica Communications, 2018 Muscle atrophy with weakness is a core feature of amyotrophic lateral sclerosis (ALS) that has long been attributed to motor neuron loss alone. However, several studies in ALS patients, and more so in animal models, have challenged this assumption with ...
Matthew D. Cykowski +5 more
doaj +1 more source
Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.This graphical abstract illustrates the dynamic bidirectional crosstalk between microRNA biogenesis and autophagy, which serves as a critical regulatory axis in cardiovascular homeostasis. We highlight how specific miRNAs modulate autophagic flux to mitigate vascular inflammation and plaque instability, while concurrently, the autophagic machinery ...
Sepehr Ebrahimi‐Dehkordi +11 more
wiley +1 more source
Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain
, 2013 The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways. p62 deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this ...
Ikeda, Akira +15 more
core +1 more source
针刺研究, 2019 ObjectiveTo investigate the effect of electroacupuncture(EA)preconditioning on autophagy in cerebral cortex tissues of rats with cerebral ischemia-reperfusion injury(CIRI),so as to explore its mechanisms underlying improvement of CIRI.MethodsThirty-three
HUANG Ya-guang +5 more
doaj +2 more sources
SchizophreniaSequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy ...
Kun Yang +3 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li +4 more
wiley +1 more source
p62/Sequestosome-1: mapping sites of protein-handling stress in canine cutaneous mast cell tumors
, 2015 Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information.
Lamm, C.G. +6 more
core +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease
, 2002 Paget's disease of bone (PDB) is a common disorder characterized by focal abnormalities of increased and disorganized bone turnover. Genetic factors are important in the pathogenesis of PDB, and in previous studies, we and others identified a locus for ...
Hocking, Lynne J. +12 more
core +1 more source