Results 1 to 10 of about 415,034 (343)

In vitro and in silico characterization of alkaline serine protease from Bacillus subtilis D9 recovered from Saudi Arabia

Heliyon, 2021
In this study, we have isolated and characterized proteolytic soil bacteria and their alkaline protease. Based on 16S rRNA sequence analysis, 12 isolates with the highest protease activity were classified as B. subtilis and B. cereus groups. B.
Amal Mahmoud, Essam Kotb, Amany I. Alqosaibi, Ahmed A. Al-Karmalawy, Ibtesam S. Al-Dhuayan, Hameedah Alabkari   +5 more
doaj   +1 more source

Dual function of a bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals. [PDF]

PLoS ONE, 2010
Bee venom contains a variety of peptides and enzymes, including serine proteases. While the presence of serine proteases in bee venom has been demonstrated, the role of these proteins in bee venom has not been elucidated.
Young Moo Choo, Kwang Sik Lee, Hyung Joo Yoon, Bo Yeon Kim, Mi Ri Sohn, Jong Yul Roh, Yeon Ho Je, Nam Jung Kim, Iksoo Kim, Soo Dong Woo, Hung Dae Sohn, Byung Rae Jin   +11 more
doaj   +1 more source

Novel inhibitors and activity-based probes targeting serine proteases

Frontiers in Chemistry, 2022
Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson, James A. Reihill, S. Lorraine Martin, Brian Walker   +3 more
doaj   +1 more source

Characteristics of Mycobacterium tuberculosis serine protease Rv1043c in enzymology and pathogenicity in mice

Journal of Integrative Agriculture, 2023
The serine proteases of Mycobacteria tuberculosis (Mtb) are important contributors to the process of bacterial invasion and its pathogenesis. In the present study, we systematically characterized the role of the Rv1043c protein in Mycobacterium infection
Yang-yang TANG, Ying-ying CUI, Yan-yan JIANG, Ming-zhu SHAO, Xin-xin ZANG, Guang-hui DANG, Si-guo LIU   +6 more
doaj   +1 more source

HtrA1 serine protease expression levels on age-related macular degeneration (AMD) patients in Yogyakarta

BIO Web of Conferences, 2020
This research aims to investigate the HtrA1 serine protease circulating level of Age-related Macular Degeneration (AMD) patients in Yogyakarta, Indonesia.
Supanji Supanji, Bahana Ilham Perdamaian Ayudha, Dianratri Anindita, Syifarahmah Anditta, Wahyu Widayanti Tri, Setya Wardhana Firman, Bayu Sasongko Muhammad, Eko Prayogo Mohammad, Nurini Agni Angela, Oka Chio   +9 more
doaj   +1 more source

Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-α pathway. [PDF]

PLoS ONE, 2012
The activity of the serine protease in the German cockroach allergen is important to the development of allergic disease. The protease-activated receptor (PAR)-2, which is expressed in numerous cell types in lung tissue, is known to mediate the cellular ...
Joo Young Kim, Jung Ho Sohn, Je-Min Choi, Jae-Hyun Lee, Chein-Soo Hong, Joo-Shil Lee, Jung-Won Park   +6 more
doaj   +1 more source

Gadolinium-Cyclic 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid-Click-Sulfonyl Fluoride for Probing Serine Protease Activity in Magnetic Resonance Imaging

Molecules, 2023
Serine protease is linked to a wide range of diseases, prompting the development of robust, selective, and sensitive protease assays and sensing methods.
Phuong Tu Huynh, Huy Duc Vu, Junghwa Ryu, Hee Su Kim, Hoesu Jung, Sung Won Youn   +5 more
doaj   +1 more source

New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina

BMC Evolutionary Biology, 2010
Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying, Liang Lianming, Yu Zefen, Tian Baoyu, Dong Linqian, Yang Jinkui, Yu Li, Li Juan, Wang Xu, Zhang Keqin   +9 more
doaj   +1 more source

The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult

Frontiers in Pharmacology, 2022
Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic ...
Hannah Ceuleers, Hannah Ceuleers, Hannah Ceuleers, Nikita Hanning, Nikita Hanning, Michelle De bruyn, Michelle De bruyn, Joris G De Man, Joris G De Man, Heiko U De Schepper, Heiko U De Schepper, Heiko U De Schepper, Qian Li, Liansheng Liu, Steven Abrams, Steven Abrams, Annemieke Smet, Annemieke Smet, Jurgen Joossens, Koen Augustyns, Koen Augustyns, Ingrid De Meester, Ingrid De Meester, Pankaj J Pasricha, Benedicte Y De Winter, Benedicte Y De Winter, Benedicte Y De Winter   +26 more
doaj   +1 more source

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources