New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina [PDF]
BMC Evolutionary Biology, 2010 Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying +9 more
doaj +4 more sources
A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa [PDF]
Veterinary Research, 2011 Several alphaherpesviruses breach the basement membrane during mucosal invasion. In the present study, the role of proteases in this process was examined.
Glorieux Sarah +4 more
doaj +5 more sources
Intramolecular Modulation of Serine Protease Inhibitor Activity in a Marine Cyanobacterium with Antifeedant Properties [PDF]
Marine Drugs, 2010 Extracts of the Floridian marine cyanobacterium Lyngbya cf. confervoides were found to deter feeding by reef fish and sea urchins (Diadema antillarum).
Susan Matthew +5 more
doaj +5 more sources
Ionization Behavior of the Histidine Residue in the Catalytic Triad of Serine Proteases [PDF]
, 1973 α-Lytic protease is a homologue of the mammalian serine proteases such as trypsin, chymotrypsin, and elastase, and its single histidine residue belongs to the Asp-His-Ser catalytic triad. This single histidine residue has been selectively enriched in the
Michael W. Hunkapiller +3 more
openalex +3 more sources
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA). [PDF]
PLoS Pathogens, 2008 Viruses encode suppressors of cell death to block intrinsic and extrinsic host-initiated death pathways that reduce viral yield as well as control the termination of infection.
A Louise McCormick +2 more
doaj +5 more sources
Purification and characterization of thermostable serine alkaline protease from Geobacillus sp. DS3 isolated from Sikidang crater, Dieng plateau, Central Java, Indonesia [PDF]
Indonesian Journal of Biotechnology, 2022 Thermostable proteases that optimally withstand the high‐temperature conditions of thermophilic bacteria could be produced and purified, which would be highly beneficial for use in industry. Geobacillus sp.
Sotharith Phon +2 more
doaj +3 more sources
Early diagnosis of Trichinella spiralis and Trichinella nativa: Expression of the serine protease gene at the invasive intestinal and muscular larva stages [PDF]
Veterinary WorldBackground and Aim: Diagnosis of trichinellosis at the intestinal stage during larval development is the primary challenge in the early detection and treatment of trichinellosis. The use of serine protease as a diagnostic marker for serological tests has
Orken S. Akibekov +8 more
doaj +2 more sources
Disruption of the c‐terminal serine protease domain of Fam111a does not alter calcium homeostasis in mice [PDF]
Physiological ReportsFAM111A gene mutations cause Kenney–Caffey syndrome (KCS) and Osteocraniostenosis (OCS), conditions characterized by short stature, low serum ionized calcium (Ca2+), low parathyroid hormone (PTH), and bony abnormalities. The molecular mechanism mediating
Rebecca Siu Ga Tan +5 more
doaj +2 more sources
Dual function of a bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals. [PDF]
PLoS ONE, 2010 Bee venom contains a variety of peptides and enzymes, including serine proteases. While the presence of serine proteases in bee venom has been demonstrated, the role of these proteins in bee venom has not been elucidated.
Young Moo Choo +11 more
doaj +1 more source
Novel inhibitors and activity-based probes targeting serine proteases
Frontiers in Chemistry, 2022 Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson +3 more
doaj +1 more source