Results 1 to 10 of about 797,226 (340)

Identification and characterization of fusolisin, the Fusobacterium nucleatum autotransporter serine protease. [PDF]

PLoS ONE, 2014
Fusobacterium nucleatum is an oral anaerobe associated with periodontal disease, adverse pregnancy outcomes and colorectal carcinoma. A serine endopeptidase of 61-65 kDa capable of damaging host tissue and of inactivating immune effectors was detected ...
Lior Doron, Shunit Coppenhagen-Glazer, Yara Ibrahim, Amir Eini, Ronit Naor, Graciela Rosen, Gilad Bachrach   +6 more
doaj   +2 more sources

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

eLife, 2021
Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo.
A. Mykytyn, T. I. Breugem, Samra Riesebosch, D. Schipper, Petra B. van den Doel, R. Rottier, M. Lamers, B. Haagmans   +7 more
semanticscholar   +1 more source

Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy

Journal of the American Society of Nephrology, 2021
Visual Abstract Significance Statement Membranous nephropathy (MN) is a glomerular disease that often leads to nephrotic syndrome and is caused by autoantibodies that target podocyte proteins.
Laith F Al-Rabadi, Tiffany N. Caza, Claire Trivin-Avillach, Aylin R. Rodan, Nicole K. Andeen, Norifumi Hayashi, B. Williams, M. Revelo, F. Clayton, J. Abraham, Edwin Lin, Willisa Liou, Chang-jiang Zou, N. Ramkumar, Timothy D. Cummins, D. Wilkey, I. Kawalit, C. Herzog, Aaron J. Storey, R. Edmondson, R. Sjoberg, Tianxin Yang, J. Chien, M. Merchant, J. Arthur, J. Klein, C. Larsen, L. Beck   +27 more
semanticscholar   +1 more source

In vitro and in silico characterization of alkaline serine protease from Bacillus subtilis D9 recovered from Saudi Arabia

Heliyon, 2021
In this study, we have isolated and characterized proteolytic soil bacteria and their alkaline protease. Based on 16S rRNA sequence analysis, 12 isolates with the highest protease activity were classified as B. subtilis and B. cereus groups. B.
Amal Mahmoud, Essam Kotb, Amany I. Alqosaibi, Ahmed A. Al-Karmalawy, Ibtesam S. Al-Dhuayan, Hameedah Alabkari   +5 more
doaj   +1 more source

Discovery and biochemical characterization of the D-aspartyl endopeptidase activity of the serine protease LACTB. [PDF]

J Biol Chem
Ito G, Utsunomiya-Tate N.
europepmc   +2 more sources

Dual function of a bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals. [PDF]

PLoS ONE, 2010
Bee venom contains a variety of peptides and enzymes, including serine proteases. While the presence of serine proteases in bee venom has been demonstrated, the role of these proteins in bee venom has not been elucidated.
Young Moo Choo, Kwang Sik Lee, Hyung Joo Yoon, Bo Yeon Kim, Mi Ri Sohn, Jong Yul Roh, Yeon Ho Je, Nam Jung Kim, Iksoo Kim, Soo Dong Woo, Hung Dae Sohn, Byung Rae Jin   +11 more
doaj   +1 more source

Novel inhibitors and activity-based probes targeting serine proteases

Frontiers in Chemistry, 2022
Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson, James A. Reihill, S. Lorraine Martin, Brian Walker   +3 more
doaj   +1 more source

Characteristics of Mycobacterium tuberculosis serine protease Rv1043c in enzymology and pathogenicity in mice

Journal of Integrative Agriculture, 2023
The serine proteases of Mycobacteria tuberculosis (Mtb) are important contributors to the process of bacterial invasion and its pathogenesis. In the present study, we systematically characterized the role of the Rv1043c protein in Mycobacterium infection
Yang-yang TANG, Ying-ying CUI, Yan-yan JIANG, Ming-zhu SHAO, Xin-xin ZANG, Guang-hui DANG, Si-guo LIU   +6 more
doaj   +1 more source

Fecal Serine Protease Profiling in Inflammatory Bowel Diseases

Frontiers in Cellular and Infection Microbiology, 2020
Serine proteases are extensively known to play key roles in many physiological processes. However, their dysregulation is often associated to several diseases including inflammatory bowel diseases (IBD). Here, we used specific substrates to monitor fecal
Amin Jablaoui, Aïcha Kriaa, Héla Mkaouar, Nizar Akermi, Souha Soussou, M. Wysocka, Dominika Wołoszyn, A. Amouri, A. Gargouri, E. Maguin, A. Lesner, M. Rhimi   +11 more
semanticscholar   +1 more source

Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy

Cell Death and Disease, 2020
Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease participates in mitochondrial protein quality control by degrading misfolded or damaged proteins, thus maintaining normal metabolic function. Mitochondrial ClpP is
K. Nouri, Yue Feng, A. Schimmer
semanticscholar   +1 more source