Results 31 to 40 of about 95,130 (254)
Frontiers in Immunology, 2022 Several serine proteases have been linked to autoimmune disorders and tumour initiation although the mechanisms are not fully understood. Activation of the kynurenine pathway enzyme indoleamine-2,3-dioxygenase (IDO1) modulates cellular activity in the ...
Felix I. L. Clanchy +6 more
doaj +1 more source
Serine proteases, their inhibitors and allergy [PDF]
Allergy, 2006 This paper reviews four serine protease inhibitors and three protease gene defects that are associated with allergic conditions, suggesting an important role for these genes and their products in the development of allergy. Serine protease inhibitors may have a therapeutic potential in the treatment of allergy.
Smith, P K, Harper, J I
openaire +2 more sources
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation
EMBO Molecular Medicine, 2021 SPINK6 was identified in human skin as a cellular inhibitor of serine proteases of the KLK family. Airway serine proteases are required to cleave hemagglutinin (HA) of influenza A viruses (IAVs) to initiate an infection in the human airway.
Dong Wang +15 more
doaj +1 more source
BMC Genomics, 2008 Background Serine proteases are one of the most abundant groups of proteolytic enzymes found in all the kingdoms of life. While studies have established significant roles for many prokaryotic serine proteases in several physiological processes, such as ...
Tripathi Lokesh P, Sowdhamini R
doaj +1 more source
Airway proteolytic control of pneumococcal competence.
PLoS Pathogens, 2023 Streptococcus pneumoniae is an opportunistic pathogen that colonizes the upper respiratory tract asymptomatically and, upon invasion, can lead to severe diseases including otitis media, sinusitis, meningitis, bacteremia, and pneumonia.
Haley Echlin +3 more
doaj +1 more source
New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina
BMC Evolutionary Biology, 2010 Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying +9 more
doaj +1 more source
eLife, 2021 Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in vivo.
Anna Z Mykytyn +7 more
doaj +1 more source
The epidermolytic toxins are serine proteases [PDF]
FEBS Letters, 1990 Certain strains of Staphylococcus aureus usually belonging to phage group II produce epidermolytic toxins (ETA and ETB) which cause intraepidermal splitting in mice, neonates and occasionally adults. Amino acid sequences of ETA and ETB have been reported but the mechanism of epidermolysis remains unknown.
Dancer, Stephanie J. +4 more
openaire +2 more sources
Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets
Interdisciplinary Perspectives on Infectious Diseases, 2014 Malaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs.
Asrar Alam
doaj +1 more source
The HtrA family of serine proteases [PDF]
Molecular Microbiology, 1997 HtrA, also known as DegP and probably identical to the Do protease, is a heat shock‐induced serine protease that is active in the periplasm of Escherichia coli. Homologues of HtrA have been described in a wide range of bacteria and in eukaryotes. Its chief role is to degrade misfolded proteins in the periplasm.
M J, Pallen, B W, Wren
openaire +2 more sources