The under‐appreciated world of the serpin family of serine proteinase inhibitors [PDF]
EMBO Molecular Medicine, 2023 In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in ...
Marie‐Christine Bouton +9 more
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Kazal-type serine proteinase inhibitors in the midgut of Phlebotomus papatasi [PDF]
Memorias do Instituto Oswaldo Cruz, 2013 Sandflies (Diptera: Psychodidae) are important disease vectors of parasites of the genus Leishmania, as well as bacteria and viruses. Following studies of the midgut transcriptome of Phlebotomus papatasi, the principal vector of Leishmania major, two non-
Leah Theresa Sigle +1 more
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Primary Structure of Potato Kunitz-Type Serine Proteinase Inhibitor [PDF]
Biological Chemistry, 2000 The serine proteinase inhibitor (PSPI-21) isolated from potato tubers (Solanum tuberosum L.) comprises two protein species with pI 5.2 and 6.3, denoted as PSPI-21-5.2 and PSPI-21-6.3, respectively. They were separated by anion exchange chromatography on a Mono Q FPLC column.
Valueva, Tatyana A. +3 more
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Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors
Journal of Insect Physiology, 1997 Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval Helicoverpa zea, Agrotis ipsilon, and Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI.
Roxanne M. Broadway
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Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer [PDF]
Scientific Reports, 2018 Amphibian venom-derived peptides have high potential in the field of anticancer drug discovery. We have isolated a novel Bowman-Birk proteinase inhibitor (BBI)-type peptide from the skin secretion of Pelophylax esculentus (PE) named PE-BBI, and evaluated
Peng Lyu +7 more
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Analysis of serine proteinase–inhibitor interaction by alanine shaving [PDF]
Protein Science, 2002 AbstractWe analyzed the energetic importance of residues surrounding the hot spot (the P1 position) of bovine pancreatic trypsin inhibitor (BPTI) in interaction with two proteinases, trypsin and chymotrypsin, by a procedure called molecular shaving.
Olga Buczek +4 more
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Identification and purification of a novel serine proteinase inhibitor
Journal of Biological Chemistry, 1993 We report the identification, purification, and partial amino acid sequence of a novel serine proteinase inhibitor which is present in extracts from human placentas and in the cytosolic fraction of the leukemic cell line K562. Extracts from these tissues exhibited time-dependent inhibition of the serine proteinase thrombin.
Paul Coughlin, T. Tetaz, Hatem H. Salem
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Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes in Solanum lycopersicum in Response to Feeding by Tuta absoluta [PDF]
InsectsUnderstanding plant-insect interactions can help control the harm of herbivorous pests. According to transcriptome data, transcripts of Solanum lycopersicum responding to feeding by Tuta absoluta were screened for important endopeptidase inhibitors ...
Yan Zhou +4 more
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Domain 15 of the serine proteinase inhibitor LEKTI blocks HIV infection <em>in vitro</em>
The International Journal of Biochemistry & Cell Biology, 2013 Proteinase inhibitors are important negative regulators of proteinase action in vivo and are thus involved in several pathophysiological processes. Starting with the isolation of two new peptides from human blood filtrate, we succeeded in cloning a cDNA encoding the precursor protein for a novel 15-domain Kazal-type-related serine proteinase inhibitor.
David Palesch +7 more
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In-silico comparative study of inhibitory mechanism of Plant Serine Proteinase Inhibitors. [PDF]
Bioinformation, 2012 Siva Prasad CV +3 more
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