Analysis of serine proteinase–inhibitor interaction by alanine shaving [PDF]
Protein Science, 2002 AbstractWe analyzed the energetic importance of residues surrounding the hot spot (the P1 position) of bovine pancreatic trypsin inhibitor (BPTI) in interaction with two proteinases, trypsin and chymotrypsin, by a procedure called molecular shaving.
Olga, Buczek +4 more
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Camostat Does Not Inhibit the Proteolytic Activity of Neutrophil Serine Proteases
Pharmaceuticals, 2022 Coronavirus disease 2019 (COVID-19) can lead to multi-organ failure influenced by comorbidities and age. Binding of the severe acute respiratory syndrome coronavirus 2 spike protein (SARS-CoV-2 S protein) to angiotensin-converting enzyme 2 (ACE2), along ...
Akmaral Assylbekova +5 more
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Degradation of human kininogens with the release of kinin peptides by extracellular proteinases of Candida spp. [PDF]
, 2010 The secretion of proteolytic enzymes by pathogenic microorganisms is one of the most successful strategies used by pathogens to colonize and infect the host organism.
Ben Nasr A. +16 more
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European Journal of Entomology, 2005 Proteinase activity in the midgut of the pentatomid stinkbug Podisus maculiventris was investigated. The optimal pH for adult and nymph proteolysis was pH 6.0 and pH 6.5, respectively.
Howard A. BELL +4 more
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Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]
, 1989 Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY +7 more
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Serine proteinase inhibitors from insect hemolymph.
Acta Biochimica Polonica, 1996 Insect hemolymph, like vertebrate serum, contains several different types of polypeptides that are able to inhibit the catalytic function of proteolytic enzymes, however studies on proteins possessing this capability have been limited to a relatively few species.
A, Polanowski, T, Wilusz
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Antiviral Cytokines Induce Hepatic Expression of the Granzyme B Inhibitors, Proteinase Inhibitor 9 and Serine Proteinase Inhibitor 6 [PDF]
The Journal of Immunology, 2004 Abstract Expression of the granzyme B inhibitors, human proteinase inhibitor 9 (PI-9), or the murine orthologue, serine proteinase inhibitor 6 (SPI-6), confers resistance to CTL or NK killing by perforin- and granzyme-dependent effector mechanisms.
Mahmoud B, Barrie +4 more
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TRANSGENIC PLANTS RESISTANT TO INSECTS [PDF]
Poljoprivreda, 2009 Proteinase inhibitors are secondary metabolites present in all plants and it seems that their major role is protection of plants against attacks of animals, insects and microorganisms.
S. Kereša +4 more
doaj
Paradigm of biased PAR1 (protease-activated receptor-1) activation and inhibition in endothelial cells dissected by phosphoproteomics [PDF]
, 2017 Thrombin is the key serine protease of the coagulation cascade and mediates cellular responses by activation of PARs (protease-activated receptors). The predominant thrombin receptor is PAR1, and in endothelial cells (ECs), thrombin dynamically regulates
Hoogendijk, Arie J. +7 more
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Squash inhibitor family of serine proteinases.
Acta Biochimica Polonica, 1996 Squash inhibitors of serine proteinases form an uniform family of small proteins. They are built of 27-33 amino-acid residues and cross-linked with three disulfide bridges. The reactive site peptide bond (P1-P1') is between residue 5 (Lys, Arg or Leu) and 6 (always Ile). High resolution X-ray structures are available for two squash inhibitors complexed
J, Otlewski, D, Krowarsch
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