Results 21 to 30 of about 60,901 (333)
A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors
Current Issues in Molecular Biology, 2023 SARS-CoV-2 (severe acute respiratory syndrome) is highly infectious and causes severe acute respiratory distress syndrome (SARD), immune suppression, and multi-organ failure. For SARS-CoV-2, only supportive treatment options are available, such as oxygen
Desh Deepak Singh +3 more
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Pest protection conferred by a Beta vulgaris serine proteinase inhibitor gene. [PDF]
PLoS ONE, 2013 Proteinase inhibitors provide a means of engineering plant resistance to insect pests. A Beta vulgaris serine proteinase inhibitor gene (BvSTI) was fused to the constitutive CaMV35S promoter for over-expression in Nicotiana benthamiana plants to study ...
Ann C Smigocki +3 more
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Non‐peptide inhibitors of HCV serine proteinase [PDF]
FEBS Letters, 1998 We screened a chemical library of 2000 compounds for inhibitors of hepatitis C virus (HCV) serine proteinase using an in vitro screening method measuring the hydrolysis of the peptide substrate. Three compounds were found to be the most potent inhibitors (IC50<10−5 M).
Yasumasa Komoda +6 more
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The effect of melanin on the proteolytic potential of blood under alkali esophageal burn
Journal of Biological Research, 2020 Caustic esophageal burns are among serious medical problems of global significance. Due to a key role in biological processes proteolytic enzymes actively involved in the pathological mechanisms underpinning the development and progression of burn ...
Nataliia Chornenka +9 more
doaj +1 more source
A KLK4 proteinase substrate capture approach to antagonize PAR1
Scientific Reports, 2021 Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis.
Eitan Rabinovitch +8 more
doaj +1 more source
Frontiers in Chemistry, 2021 During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications,
Timo Burster +4 more
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The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases [PDF]
Biochemical Journal, 1986 A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane ...
Brian Walker +3 more
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Study on Serine Proteinase in the Muscle of Yesso Scallops (Mizuhopecten yessoensis）
Shipin gongye ke-ji, 2022 To investigate the effect of endogenous protease on the texture of Yesso scallop muscle during cold storage, the texture and protein change related indexes of Yesso scallop muscle was measured during 4 ℃ cold storage 7 d with a purpose to identify the ...
Qiuying REN +6 more
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Identification of three stage-specific proteinases of Plasmodium falciparum. [PDF]
, 1987 We have identified and characterized three stage-specific proteinases of Plasmodium falciparum that are active at neutral pH. We analyzed ring-, trophozoite-, schizont-, and merozoite-stage parasites by gelatin substrate PAGE and characterized the ...
Kim, K +3 more
core +2 more sources
Protein inhibitors of serine proteinases.
Acta Biochimica Polonica, 1999 Serine proteinases and their natural protein inhibitors belong to the most intensively studied models of protein-protein recognition. Protein inhibitors do not form a single group but can be divided into about 20 different families. Global structures of proteins representing different inhibitor families are completely different and comprise alpha ...
Daniel Krowarsch +2 more
openaire +4 more sources