Results 181 to 190 of about 234,379 (321)

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Computer‐aided Evaluation of Polyvalent Medications’ Pharmacological Potential. Multiphytoadaptogen as a Case Study

open access: yesMolecular Informatics, Volume 42, Issue 1, January 2023., 2023
Abstract Many human diseases including cancer, degenerative and autoimmune disorders, diabetes and others are multifactorial. Pharmaceutical agents acting on a single target do not provide their efficient curation. Multitargeted drugs exhibiting pleiotropic pharmacological effects have certain advantages due to the normalization of the complex ...
O. A. Bocharova   +18 more
wiley   +1 more source

Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain. [PDF]

open access: yesMicrob Biotechnol
Planells-Cárcel A   +5 more
europepmc   +1 more source

Prophylactic Effects of Astragalus Polysaccharides on Depression‐Like Behaviors in Rats With Chronic Unpredictable Mild Stress: A Role of Gut‐Microbiota–Brain Axis

open access: yesFood Frontiers, EarlyView.
This study complements the pathogenesis of depression, and the effects of APS from the perspective of “gut microbiome ‐ immunity ‐ metabolome” axis. This study also provides a novel research strategy and approaches for demonstrating the anti‐depression effects of plant polysaccharides, and lays a solid foundation for discovering new medicines from ...
Xiaojie Liu   +9 more
wiley   +1 more source

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