Results 311 to 320 of about 71,732 (355)
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Receptor-Based 3D QSAR Analysis of Serotonin 5-HT1D Receptor Agonists
Collection of Czechoslovak Chemical Communications, 2005A three-dimensional quantitative structure-activity relationship study (3D QSAR) has been successfully applied to explain the binding affinities for the serotonin 5-HT1Dreceptor of a triptan series. The paper describes the development of a receptor-based 3D QSAR model of some known agonists and recently developed triptans on the 5-HT1Dserotonergic ...
Nalan Terzioglu, Hans-Dieter Höltje
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Journal of Neural Transmission, 1989
The antinociceptive effects of subcutaneous 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the responses to intrathecal (i.th.) serotonin (5-HT) and substance P (SP) were examined in mice after repeated administration of 5-MeODMT (3 mg/kg every 30 min for 4 hours).
P K, Eide, K, Hole
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The antinociceptive effects of subcutaneous 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the responses to intrathecal (i.th.) serotonin (5-HT) and substance P (SP) were examined in mice after repeated administration of 5-MeODMT (3 mg/kg every 30 min for 4 hours).
P K, Eide, K, Hole
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Serotonin (5-HT)1A Receptor Agonists and Neuroprotection
1993The activation of serotonin (5-HT)1Areceptors exerts an inhibitory influence on neuronal activity in a way similar to the activation of adenosine Al receptors. Adenosine Al receptor agonists have been shown to exert neuroprotective effects in animal models of cerebral ischemia.
J. Traber, K. M. Bode-Greuel, E. Horvath
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Headache, Raynaud’s syndrome and serotonin receptor agonists in systemic lupus erythematosus
Lupus, 2006There are potential concerns regarding serotonin receptor agonists in SLE patients with migraine, particularly patients with concomitant Raynaud’s syndrome. We estimated the prevalence of lupusrelated headache and Raynaud’s syndrome in the Montreal General Hospital SLE clinic cohort and evaluated the relationship between these two variables in ...
S, Bernatsky +3 more
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Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists
Journal of Computer-Aided Molecular Design, 2004The N-terminal extracellular regions of heterooligomeric 3AB-type human 5-hydroxytryptamine receptors (5-HT3ABR) were modelled based on the crystal structure of snail acetylcholine binding protein AChBP. Stepwise rotation of subunit A by 5 degrees was performed between -10 degrees and 15 degrees to mimic agonist binding and receptor activation ...
Gábor, Maksay +2 more
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Migraine headache treatment with eletriptan, a second-generation serotonin receptor agonist
Drugs of Today, 2001Eletriptan is a member of the triptan family of selective serotonin receptor agonists. These act against migraine by inducing vasoconstriction of the meningeal arteries. In pharmacological tests, eletriptan has shown high affinity for the 5-HT(1B/1D) receptors, which have been implicated in the etiology of migraine headache attacks.
P., Cole, X., Rabasseda
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[Serotonin 5- HT4 receptor agonist (mosapride citrate)].
Nihon rinsho. Japanese journal of clinical medicine, 2006Irritable bowel syndrome is a functional gastrointestinal disorder characterized by abnormal sensation and motility in the lower gastrointestinal tract. In constipation-type irritable bowel syndrome, decreased bowel motility causes stagnation of feces and gas, resulting in enhanced pain sensation of the bowel. Mosapride citrate is a selective serotonin
Takeo, Odaka +4 more
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Investigation of the 2,5-Dimethoxy Motif in Phenethylamine Serotonin 2A Receptor Agonists
ACS Chemical Neuroscience, 2020The 2,5-dimethoxyphenethylamine (2,5-PEA) scaffold is recognized as a motif conferring potent agonist activity at the serotonin 2A receptor (5-HT2AR). The 2,5-dimethoxy motif is present in several classical phenethylamine psychedelics such as 2,4,5- trimethoxyamphetamine (TMA-2), 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-iodoamphetamine (
Emil Marcher-Rørsted +6 more
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1993
Gaddum and Picarelli (1957) initially suggested the existence of more than one serotonin (5-HT) receptor over 30 years ago. Subsequently, neurophysiological, pharmacological, and other investigative techniques provided evidence that 5-HT could act at presynaptic and postsynaptic sites and could be either excitatory or inhibitory in different systems ...
K P, Lesch, C S, Aulakh, D L, Murphy
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Gaddum and Picarelli (1957) initially suggested the existence of more than one serotonin (5-HT) receptor over 30 years ago. Subsequently, neurophysiological, pharmacological, and other investigative techniques provided evidence that 5-HT could act at presynaptic and postsynaptic sites and could be either excitatory or inhibitory in different systems ...
K P, Lesch, C S, Aulakh, D L, Murphy
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Journal of Neural Transmission, 2004
Sarizotan exhibited high affinities only to serotonin 5-HT1A receptors and dopamine DA D4>D3>D2 receptors with the profile of a 5-HT1A agonist and DA antagonist demonstrated by the inhibition of cAMP-stimulation and guinea pig ileum contraction, decreased accumulation of the 5-HT precursor 5-hydroxytryptophan and increased levels of 5-HT metabolites ...
G D, Bartoszyk +5 more
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Sarizotan exhibited high affinities only to serotonin 5-HT1A receptors and dopamine DA D4>D3>D2 receptors with the profile of a 5-HT1A agonist and DA antagonist demonstrated by the inhibition of cAMP-stimulation and guinea pig ileum contraction, decreased accumulation of the 5-HT precursor 5-hydroxytryptophan and increased levels of 5-HT metabolites ...
G D, Bartoszyk +5 more
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