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Irish Journal of Psychological Medicine, 2011
Serotonin toxicity is a potentially life-threatening condition associated with a range of psychotropic medications, co-administration of specific combinations of agents and overdose of certain drugs. It is associated with a wide diversity of clinical signs and symptoms, including cognitive, autonomic and somatic effects, as well as serious ...
Sobia, Nasim +3 more
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Serotonin toxicity is a potentially life-threatening condition associated with a range of psychotropic medications, co-administration of specific combinations of agents and overdose of certain drugs. It is associated with a wide diversity of clinical signs and symptoms, including cognitive, autonomic and somatic effects, as well as serious ...
Sobia, Nasim +3 more
openaire +3 more sources
Serotonin Toxicity in Older People
The Senior Care Pharmacist, 2022Serotonin toxicity, sometimes referred to as serotonin syndrome, results in a triad of clinical features that include autonomic signs, neuromuscular changes, and altered mental status, which may range from mild symptoms to fatal toxicity. As a result, serotonin toxicity is best thought of as a spectrum of symptoms rather than as a syndrome.
J Michael, McGuire, Amy, Werremeyer
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Serotonin toxicity of serotonergic psychedelics
Psychopharmacology, 2021In recent years, psychedelic substances with serotonergic mechanisms have accumulated substantial evidence that they may provide therapeutic benefits for people suffering with psychiatric symptoms. Psychiatric disorders targeted by these psychedelic-assisted therapies are managed with serotonergic drugs like selective serotonin reuptake inhibitors ...
Benjamin Malcolm, Kelan Thomas
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Pharmacogenomics Journal, 2014 Serotonin toxicity results from serotonin excess in the central nervous system from serotonergic drugs. Previous studies suggest an association between T102C polymorphism of the serotonin 2A (5-hydroxytryptamine 2A) receptor gene and serotonergic adverse
Ian Whyte +2 more
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Journal of Clinical Psychopharmacology, 2019
Abstract Background Serotonin toxicity is a common cause of drug-induced altered mental status. However, data on the causes of serotonin toxicity, symptomatology, complications, and rate of antidotal treatment are limited.
Michael J, Moss, Robert G, Hendrickson
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Abstract Background Serotonin toxicity is a common cause of drug-induced altered mental status. However, data on the causes of serotonin toxicity, symptomatology, complications, and rate of antidotal treatment are limited.
Michael J, Moss, Robert G, Hendrickson
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Toxicity of a serotonin-derived neuromelanin
Biochemical and Biophysical Research Communications, 2010Postoperative Cognitive Dysfunction (POCD) is associated with increased mortality in the elderly and may occur from lipid peroxidation in aging. We previously showed that sevoflurane sequesters acrolein, which promotes the formation of a novel species of a putative neuromelanin.
Elizabeth D, Miller +2 more
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Clinical Toxicology, 2017 Context: Desvenlafaxine is used to treat major depression. Desvenlafaxine is also the active metabolite of venlafaxine. Venlafaxine overdose can cause serotonin toxicity, seizures and cardiovascular effects, but there is limited information on ...
Geoffrey Isbister
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Veterinary Record, 2007
SIR, — The Veterinary Poisons Information Service (vpis) has received a small number of inquiries concerning dogs with serious clinical effects following accidental ingestion of 5-hydroxytryptophan (5-htp) and wishes to highlight the risks of serotonin toxicity with this drug.
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SIR, — The Veterinary Poisons Information Service (vpis) has received a small number of inquiries concerning dogs with serious clinical effects following accidental ingestion of 5-hydroxytryptophan (5-htp) and wishes to highlight the risks of serotonin toxicity with this drug.
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Serotonin Toxicity as a Source of Iatrogenic Harm
The Senior Care Pharmacist, 2022In this edition of the journal, we see discussion of serotonin toxicity, an important but under-recognized problem that many pharmacists will encounter from time to time in caring for older people. In fact, the issue is not new. What has changed is that unlike the situation previously, where the problem was defined syndromally, with specific diagnostic
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