Results 41 to 50 of about 709,580 (281)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Clinical Severity and Serotonin Toxicity in Antidepressant Self-Poisoning: Implications for Clinical Risk Assessment

Psychiatry and Clinical Psychopharmacology
Background: Antidepressant self-poisoning is a common form of intentional self-harm, and comparisons across antidepressant groups are complicated by differences in ingested dose and coexposures.
Meltem Gürü, Merve Unutmaz
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

The serotonin toxidrome: shortfalls of current diagnostic criteria for related syndromes

, 2021
Serotonin syndrome (toxicity) describes adverse drug effects from toxic amounts of intra-synaptic central nervous system serotonin. A wide range of drugs have been implicated to cause serotonin toxicity, not all justifiably. The plausible agents all have
Angela L. Chiew (4169770), Nicholas A. Buckley (7294397)   +1 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A case of serotonin syndrome following the reintroduction of aripiprazole after dextromethorphan overdose

PCN Reports
Background Serotonin syndrome is a potentially life‐threatening condition that arises from excessive serotonergic activity. Dextromethorphan (DXM), commonly used as a non‐prescription antitussive, can induce serotonin syndrome when taken in high doses or
Naoko Saito, Nobuhiko Noguchi, Maki Toida, Masatoshi Miyauchi, Takeshi Asami   +4 more
doaj   +1 more source

Molecular and behavioral responses of zebrafish embryos/larvae after sertraline exposure

Ecotoxicology and Environmental Safety, 2021
Sertraline (SER) is one of the most frequently detected antidepressant drugs in aquatic environments. However, knowledge regarding SER-induced behavioral alterations in fish is insufficient, as well as the mechanisms underlying SER-induced toxicity.
Huiting Yang, Xuefang Liang, Yanyan Zhao, Xiaohong Gu, Zhigang Mao, Qingfei Zeng, Huihui Chen, Christopher J. Martyniuk   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Predictors of Serotonin Syndrome in Acute Poisoning with 5-Hydroxytryptamine Modulators

Toxics
5-Hydroxytryptamine (5-HT) modulators are commonly prescribed medications with potentially life-threatening outcomes, particularly serotonin syndrome (SS). Early prediction of SS is critical not only to avoid lethal drug combinations but also to initiate
Asmaa F. Sharif, Mubarak Nasir M. Almulhim, Hadi Mohamed A. Almosabeh, Mohammed Essam A. Alshammasy, Ali Mohammed A. Aljeshi, Taher Mohammed A. Mufti, Shahd AlNasser, Khalid A. Al-Mulhim, Yousef A. AlMubarak   +8 more
doaj   +1 more source