Results 61 to 70 of about 72,544 (286)

Predictors of Serotonin Syndrome in Acute Poisoning with 5-Hydroxytryptamine Modulators

Toxics
5-Hydroxytryptamine (5-HT) modulators are commonly prescribed medications with potentially life-threatening outcomes, particularly serotonin syndrome (SS). Early prediction of SS is critical not only to avoid lethal drug combinations but also to initiate
Asmaa F. Sharif, Mubarak Nasir M. Almulhim, Hadi Mohamed A. Almosabeh, Mohammed Essam A. Alshammasy, Ali Mohammed A. Aljeshi, Taher Mohammed A. Mufti, Shahd AlNasser, Khalid A. Al-Mulhim, Yousef A. AlMubarak   +8 more
doaj   +1 more source

Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. [PDF]

PLoS ONE, 2016
3,4-methylenedioxymethamphetamine (MDMA; ecstasy) is a commonly abused recreational drug that causes neurotoxic effects in both humans and animals. The mechanism behind MDMA-induced neurotoxicity is suggested to be species-dependent and needs to be ...
Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson   +3 more
doaj   +1 more source

Monoaminergic Neuropathology in Alzheimer's disease [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant. no. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Bažadona, Danira, Buée, Luc, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles R., Hof, Patrick R., Jovanov-Milošević, Nataša, Leko, Mirjana Babić, Silva, Rohan de, Wischik, Claude M., Wray, Selina, Šimić, Goran   +11 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Serotonin Syndrome in the Setting of Lamotrigine, Aripiprazole, and Cocaine Use

Case Reports in Medicine, 2015
Serotonin syndrome is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. It is classically associated with the simultaneous administration of two serotonergic agents, but it can occur ...
Anupam Kotwal, Sarah L. Cutrona
doaj   +1 more source

Dietary antioxidants impact DDT resistance in Drosophila melanogaster.

PLoS ONE, 2020
Insects experience a diversity of subtoxic and/or toxic xenobiotics through exposure to pesticides and, in the case of herbivorous insects, through plant defensive compounds in their diets.
Gamal A M Abdu-Allah, Keon Mook Seong, Omprakash Mittapalli, James Adebayo Ojo, Weilin Sun, Omar Posos-Parra, David Mota-Sanchez, John M Clark, Barry R Pittendrigh   +8 more
doaj   +1 more source

In Vivo Electrochemical Monitoring of Safinamide Pharmacokinetics in the Brain Explores Its Correlation With Vision‐Related Neuronal Activity

Advanced Science, EarlyView.
An electrochemical platform based on differential pulse amperometry enables real‐time, selective tracking of safinamide pharmacokinetics in the living brain with high spatiotemporal resolution. When integrated with electrophysiology, this approach reveals that drug‐induced suppression of vision‐related neuronal activity provides mechanistic insight ...
Xiaoke Nan, Chuqi Li, Qianhe Dai, Junlan Zhou, Lijiao Cao, Yuying Liu, Jinger Chen, Meiping Xiong, Yuhang Jiang, Xianchan Li   +9 more
wiley   +1 more source

Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum

Frontiers in Public Health, 2023
Humans are exposed to lead (Pb), mercury (Hg), and cadmium (Cd) through various routes, including drinking water, and such exposure can lead to a range of toxicological effects.
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Kim   +3 more
doaj   +1 more source

Characterization of Vesicular Monoamine Transporter 2 and its role in Parkinson\u27s Disease Pathogenesis using Drosophila [PDF]

, 2016
Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the Substantia nigra pars compacta region of the brain.
Tito, Antonio Joel, Jr., Zhang, Sheng
core   +1 more source