Results 71 to 80 of about 709,580 (281)

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Moclobemide poisoning: toxicokinetics and occurrence of serotonin toxicity [PDF]

British Journal of Clinical Pharmacology, 2003
Aims  To investigate the spectrum of toxicity of moclobemide overdose, the occurrence of serotonin toxicity, and to estimate toxicokinetic parameters.Methods  All moclobemide overdoses presenting over a 10‐year period to the Hunter Area Toxicology Service were reviewed.
Geoffrey K, Isbister, L P, Hackett, Andrew H, Dawson, Ian M, Whyte, Anthony J, Smith   +4 more
openaire   +2 more sources

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Fluoxetine prevents Aβ1-42-induced toxicity via a paracrine signaling mediated by Transforming-Growth-Factor-β1

Frontiers in Pharmacology, 2016
Selective reuptake inhibitors (SSRIs), such as fluoxetine and sertraline, increase circulating Transforming-Growth-Factor-β1 (TGF-ß1) levels in depressed patients,and are currently studied for their neuroprotective properties in Alzheimer’s disease (AD).
Filippo Caraci, Filippo Caraci, Fabio Tascedda, Sara Merlo, Cristina Benatti, Simona Federica Spampinato, Antonio Munafò, Gian Marco Leggio, Ferdinando Nicoletti, Ferdinando Nicoletti, Nicoletta Brunello, Filippo Drago, Maria Angela Sortino, Agata Copani, Agata Copani   +14 more
doaj   +1 more source

Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain.

PLoS Biology, 2020
It was recently suggested that supplying the brain with new neurons could counteract Alzheimer's disease (AD). This provocative idea requires further testing in experimental models in which the molecular basis of disease-induced neuronal regeneration ...
Prabesh Bhattarai, Mehmet Ilyas Cosacak, Violeta Mashkaryan, Sevgican Demir, Stanislava Dimitrova Popova, Nambirajan Govindarajan, Kerstin Brandt, Yixin Zhang, Weipang Chang, Konstantinos Ampatzis, Caghan Kizil   +10 more
doaj   +1 more source

Serotonin syndrome: a spectrum of toxicity [PDF]

BJPsych Advances, 2015
SummarySerotonin syndrome (serotonin toxicity or serotonin toxidrome) is a potentially serious and theoretically predictable reaction that appears to be rarely diagnosed in practice in the UK. Some symptoms of serotonin syndrome overlap with features of other presentations in psychiatry and thus may be misattributed to mental illness (‘diagnostic ...
openaire   +1 more source

Recurrence of Serotonin Toxicity and Influence of Cytochrome 2D6 Polymorphism.

, 2019
Serotonin toxicity may be observed when the therapeutic use of antidepressants influences serotoninergic neurotransmission. There is a gradation in the severity of the clinical manifestations, usually with a rapid improvement when the offending drug is ...
Hantson, Philippe, Haufroid, Vincent, Volon, Brieuc, Willemart, Thierry   +3 more
core   +1 more source