Results 91 to 100 of about 267,093 (291)

5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release

Scientific Reports
The neurotransmitter serotonin plays a pivotal role in mood and depression. It also acts as a vasoconstrictor within blood vessels and is the main neurotransmitter in the gastrointestinal system.
Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinning   +5 more
doaj   +1 more source

Neuroreceptor imaging in depression

Neurobiology of Disease, 2013
The in vivo study of receptor binding potential in the human brain is made possible by positron emission tomography (PET) imaging. Here we review PET studies of neuroreceptor function in mood disorders — specifically, major depressive disorder (MDD) and ...
Jonathan B. Savitz, Wayne C. Drevets
doaj   +1 more source

An ETH‐LAD trip with unfavourable consequences: A case report

British Journal of Clinical Pharmacology, EarlyView.
Numerous analogues of the psychedelic and internationally controlled hallucinogen LSD have been described; however, only a limited number have been systematically investigated. This report presents the first case with an analytically confirmed ingestion of ETH‐LAD (6‐ethyl‐6‐nor‐lysergic acid diethylamide), the N‐ethyl derivative of LSD.
Johannes Nadler, Michaela Sommer, Annette Zschiesche, Anne Stürzebecher, Christina Grumann, Volker Auwärter, Maren Hermanns‐Clausen   +6 more
wiley   +1 more source

A Feasibility Analysis on Individualized Acupuncture Treatment of Irritable Bowel Syndrome under Help of Genetic Polymorphism Technique

针刺研究, 2014
Along with the application of genetic polymorphism techniques to individualized treatment of clinical disorders,the screening of polymorphisms markers of serotonin(5-HT)transporter(SERT)is a hot-spot of researches on irritable bowel syndrome(IBS).In the ...
WU Xiao-liang, SUN Jian-hua, LIU Lan-ying, FU Hai-yang, JIAO Dai-yan, SHU Yan-ye, CHEN Dong, LIU Cheng-yong, ZHAN Dao-wei, ZHANG Wei   +9 more
doaj   +2 more sources

Association of STin2 VNTR Polymorphism in the SLC6A4 Gene with Increased Risk of MS Disease

Bihdād, 2019
Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) that is characterized by inflammation, demyelination and axonal injury.
Sahar Esfandiary, Parisa Mohamadynejad, Mohamad Mehdi Moghani Bashi   +2 more
doaj  

Therapeutic implications of the serotonin transporter gene in depression

Biomarkers in Neuropsychiatry, 2019
Background: A natural variant of the serotonin transporter gene has been studied in mood disorders and its treatment with serotonin transporter inhibitors. It is now available on gene testing profiles to help guide treatment.
Rif S. El-Mallakh, Ziad Ali
doaj   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Serotonin Transporter Gene Polymorphisms and Bone Mineral Density in North Indian Postmenopausal Women

Türk Osteoporoz Dergisi
Objective: Osteoporosis is a serious metabolic bone disease worldwide, with genetic factors contributing significantly. We investigated the 5-HTT variable number tandem repeats (5HTTVNTR) & serotonin transporter gene 5-hydroxy tryptamine transporter ...
Priya Dixit, Israr Ahmad, Shah Waliullah, Tabrez Jafar   +3 more
doaj   +1 more source

Gabapentin as an add‐on analgesic to morphine in paediatric patients with chronic pain

British Journal of Clinical Pharmacology, EarlyView.
Aims Off‐label use of gabapentin for the treatment of chronic pain in children has increased over the last decade, with multiple clinical trials evaluating its role pain management and potential opioid‐sparing effects. To date, however, these studies appear to rely on empirical evidence without further consideration of pharmacokinetic‐pharmacodynamic ...
Paul Healy, Mariagrazia Felisi, Adriana Ceci, Oscar Della Pasqua, on Behalf of the GAPP Consortium, Corinne Alberti, Donato Bonifazi, Adriana Ceci, Thomas G. de Leeuw, Saskia N. de Wildt, Mariagrazia Felisi, Florentia Kaguelidou, Enora Le Roux, Rebecca Lundin, Laura Mangiarini, Dick Tibboel   +15 more
wiley   +1 more source

Association between serotonin transporter gene polymorphism and obsessive–compulsive disorder in the Egyptian population

Middle East Current Psychiatry
Background Obsessive–compulsive disorder (OCD) is a debilitating disorder that has multifactorial etiology including genetic, neurobiological, cognitive, and environmental influences.
Sara Mehrez, Mustafa Ahmed Neamatallah, Zeinab Gomaa, Abdel-Hady El-Gilany, Mohammed Shahda, Hiam F Elsaied   +5 more
doaj   +1 more source