Results 81 to 90 of about 267,093 (291)

Review of Metabolism, Transport and Role of Serotonin in the Body and the Relation between Serotonin and Diseases

Journal of Fasa University of Medical Sciences, 2013
Serotonin (5-hydroxytriptamine), one of the most important neurotransmitters, is synthesized from amino acid L-tryptophan in some neurons located in the central nervous system and intestine enterochromaffin cells .
Fatemeh Sholehvar, Mohammad Ali Takhshid, Maryam Rafiei   +2 more
doaj  

Sustained Exposure to 3,4-Methylenedioxymethamphetamine Induces the Augmentation of Exocytotic Serotonin Release in Rat Organotypic Raphe Slice Cultures

Journal of Pharmacological Sciences, 2010
3,4-Methylenedioxymethamphetamine (MDMA) causes serotonin efflux via serotonin transporter. Recently, we have reported that sustained exposure to MDMA induced an augmentation of serotonin release in rat raphe serotonergic slice cultures.
Kazuki Nagayasu, Maiko Kitaichi, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko   +4 more
doaj   +1 more source

Amphetamine Derivatives as Monoamine Oxidase Inhibitors

Frontiers in Pharmacology, 2020
Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects.
Miguel Reyes-Parada, Miguel Reyes-Parada, Patricio Iturriaga-Vasquez, Bruce K. Cassels   +3 more
doaj   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Ligand coupling mechanism of the human serotonin transporter differentiates substrates from inhibitors

Nature Communications
The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of serotonergic signalling and neurotransmitter homeostasis.
Ralph Gradisch, Katharina Schlögl, Erika Lazzarin, Marco Niello, Julian Maier, Felix P. Mayer, Leticia Alves da Silva, Sophie M. C. Skopec, Randy D. Blakely, Harald H. Sitte, Marko D. Mihovilovic, Thomas Stockner   +11 more
doaj   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Developmental roles of the serotonin transporter

, 2010
From invertebrates to humans, serotonin (5-HT) exerts structural effects especially during development. The 5-HT transporter (SERT) directly regulates these effects by maintaining extracellular 5-HT concentrations within a physiological range and ...
Persico A. M.
core  

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

AXONAL SEGREGATION AND ROLE OF THE VESICULAR GLUTAMATE TRANSPORTER VGLUT3 IN SEROTONIN NEURONS

Frontiers in Neuroanatomy, 2016
A subset of monoamine neurons releases glutamate as a cotransmitter due to specific expression of the vesicular glutamate transporters VGLUT2 or VGLUT3.
Aurore N Voisin, Ouissame eMnie-Filali, Nicolas eGiguère, Guillaume M Fortin, Erika eVignault, salah eEl Mestikawy, salah eEl Mestikawy, salah eEl Mestikawy, salah eEl Mestikawy, Laurent eDescarries, Louis-Eric eTrudeau, Louis-Eric eTrudeau   +11 more
doaj   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source