Results 1 to 10 of about 43,231 (331)

Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera [PDF]

PLoS Pathogens, 2017
Melanization, an important insect defense mechanism, is mediated by clip-domain serine protease (cSP) cascades and is regulated by serpins. Here we show that proteolytic activation of prophenoloxidase (PPO) and PO-catalyzed melanization kill the ...
Manli Wang, Zhihong Hu, Zhen Zou
exaly   +3 more sources

Helicobacter pylori-induced fibroblast-derived Serpin E1 promotes gastric cancer growth and peritoneal dissemination through p38 MAPK/VEGFA-mediated angiogenesis

Cancer Cell International, 2023
Background Fibroblasts, especially cancer-associated fibroblasts (CAFs), represent the predominant stromal cell population in the tumor microenvironment and have an important function in tumorigenesis by interacting with tumor cells.
Wei Cheng, Yonghui Liao, Yuan Xie, Qinrong Wang, Leilei Li, Yuanjia Chen, Yan Zhao, Jianjiang Zhou   +7 more
doaj   +2 more sources

Serpin B9 controls tumor cell killing by CAR T cells

Journal for ImmunoTherapy of Cancer, 2023
Background Initial clinical responses with gene engineered chimeric antigen receptor (CAR) T cells in cancer patients are highly encouraging; however, primary resistance and also relapse may prevent durable remission in a substantial part of the patients.
Zsolt Sebestyen, Jürgen Kuball, Shuang Li, Eric Eldering, Monique C Minnema, Eline van Diest, Sarah Grabherr, Thomas Kimman, Anne Slomp, Anne Martens, Jan Meeldijk, Niels Bovenschen, Victor Peperzak   +12 more
doaj   +2 more sources

Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis

Journal of Translational Medicine, 2022
Background Helicobacter pylori (H. pylori) can disrupt the tight junctions between gastric epithelial cells and penetrate the intercellular spaces acting on epithelial cells, normal fibroblasts (NFs), and cancer-associated fibroblasts (CAFs), but their ...
Xueshu Chen, Wei Chen, Yan Zhao, Qinrong Wang, Wenling Wang, Yining Xiang, Hang Yuan, Yuan Xie, Jianjiang Zhou   +8 more
doaj   +2 more sources

Carbohydrate-controlled serine protease inhibitor (serpin) production in Bifidobacterium longum subsp. longum

Scientific Reports, 2021
The Serine Protease Inhibitor (serpin) protein has been suggested to play a key role in the interaction of bifidobacteria with the host. By inhibiting intestinal serine proteases, it might allow bifidobacteria to reside in specific gut niches.
S. Duboux, M. Golliard, J. A. Muller, G. Bergonzelli, C. J. Bolten, A. Mercenier, M. Kleerebezem   +6 more
doaj   +2 more sources

The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases

International Journal of Molecular Sciences, 2021
Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease characterised by unregulated proteolytic destruction of lung tissue mediated via a protease-antiprotease imbalance.
James A Reihill, Fionnuala Lundy, John C Lockhart   +2 more
exaly   +2 more sources

Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement [PDF]

International Journal of Molecular Sciences, 2021
Tick saliva is a rich source of antihemostatic, anti-inflammatory, and immunomodulatory molecules that actively help the tick to finish its blood meal. Moreover, these molecules facilitate the transmission of tick-borne pathogens.
Jan Kotál, Stéphanie G. I. Polderdijk, Helena Langhansová, Monika Ederová, Larissa Almeida Martins, Z. Beránková, Adéla Chlastáková, Ondřej Hajdušek, Michail Kotsyfakis, James A. Huntington, Jindrǐch Chmelař   +10 more
openalex   +2 more sources

A serpin gene from a parasitoid wasp disrupts host immunity and exhibits adaptive alternative splicing.

PLoS Pathogens, 2023
Alternative splicing (AS) is a major source of protein diversity in eukaryotes, but less is known about its evolution compared to gene duplication (GD). How AS and GD interact is also largely understudied.
Zhichao Yan, Qi Fang, Jiqiang Song, Lei Yang, Shan Xiao, Jiale Wang, Gongyin Ye   +6 more
doaj   +2 more sources

Ai-Assisted Discovery of a Direct Physical Interaction Between a Venom Serpin from the Parasitoid Wasp Liragathis javana and a Host Serine Carboxypeptidase [PDF]

Toxins
Parasitoid wasp venoms represent highly specialized biochemical arsenals that evolved to manipulate host physiology and ensure successful development of the parasitoid offspring.
Jiale Wang, Xunyuan Jiang, Zemiao Xiao, Xuemei Tang, Kai Wan   +4 more
doaj   +2 more sources

Activity of Serpins in Context to Hydrophobic Interaction [PDF]

Biomolecules
The activity of serpins uses a specific mechanism or process. This process comprises several steps and is related to significant structural changes that involve significant displacement of chain fragments and whole molecules of protease.
Irena Roterman, Katarzyna Stapor, Grzegorz Zemanek, Dawid Dulak, Leszek Konieczny   +4 more
doaj   +2 more sources