Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases [PDF]
npj Parkinson's DiseaseParkinson’s disease (PD) exhibits substantial phenotypic variability, likely influenced, at least in part, by proteins associated with pathways integral to aging processes.
Milan Zimmermann +12 more
doaj +2 more sources
Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis [PDF]
Cell & BioscienceBackground Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors secreted by Trichinella spiralis play
Ruixue Li, Bing Zhang, Chen Chen
doaj +2 more sources
Serpin B9 is Highly Expressed in Lung Adenocarcinoma and is Associated with Progression-Free Survival [PDF]
Journal of Inflammation ResearchYue Fang,1,2,* Yi Yue,3,* Sensen Hao,1 Ying Zhang,4 Nan Liu,1 Shengling Wang,1 Yan Li,1 Hongzhi Wang1 1Galactophore Oncology Center, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei City, Anhui Province, People’s Republic of China ...
Fang Y +7 more
doaj +2 more sources
Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes [PDF]
BMC Genomics, 2009 Background The Drosophila melanogaster genome contains 29 serpin genes, 12 as single transcripts and 17 within 6 gene clusters. Many of these serpins have a conserved "hinge" motif characteristic of active proteinase inhibitors.
Micklem Gos +4 more
doaj +3 more sources
Cells, 2023 Despite the success of combined antiretroviral therapy (cART) increasing the survival rate in human immunodeficiency virus (HIV) patients, low levels of viremia persist in the brain of patients leading to glia (microglia and astrocytes)-induced ...
Yemmy Soler +5 more
doaj +1 more source
Three new Alpha1-Antitrypsin deficiency variants help to define a C-Terminal region regulating conformational change and polymerization [PDF]
, 2012 Alpha1-antitrypsin (AAT) deficiency is a hereditary disorder associated with reduced AAT plasma levels, predisposing adults to pulmonary emphysema.
Benini, F. +11 more
core +18 more sources
Cancer Cell International, 2023 Background Fibroblasts, especially cancer-associated fibroblasts (CAFs), represent the predominant stromal cell population in the tumor microenvironment and have an important function in tumorigenesis by interacting with tumor cells.
Wei Cheng +7 more
doaj +1 more source
RNAi-mediated knockdown of serine protease inhibitor genes increases the mortality of Plutella xylostella challenged by destruxin A. [PDF]
PLoS ONE, 2014 Destruxin A is a mycotoxin that is secreted by entomopathogenic fungi which has a broad-spectrum insecticidal effect. Previous transcript and protein profiling analysis showed that destruxin A has significant effects on the expression of serine protease ...
Pengfei Han +6 more
doaj +1 more source
Serpin B9 controls tumor cell killing by CAR T cells
Journal for ImmunoTherapy of Cancer, 2023 Background Initial clinical responses with gene engineered chimeric antigen receptor (CAR) T cells in cancer patients are highly encouraging; however, primary resistance and also relapse may prevent durable remission in a substantial part of the patients.
Zsolt Sebestyen +12 more
doaj +1 more source
Scientific Reports, 2021 The Serine Protease Inhibitor (serpin) protein has been suggested to play a key role in the interaction of bifidobacteria with the host. By inhibiting intestinal serine proteases, it might allow bifidobacteria to reside in specific gut niches.
S. Duboux +6 more
doaj +1 more source