Results 111 to 120 of about 43,231 (331)

Smoothing a rugged protein folding landscape by sequence-based redesign [PDF]

, 2016
The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance between function and misfolding.
Borg, NA, Bottomley, SP, Buckle, AM, Costa, MGS, Dai, W, Hoke, DE, Hollins, JJ, Irving, JA, Kass, I, Keleher, S, Marijanovic, EM, McGowan, S, Nickson, AA, Pearce, MA, Porebski, BT, Webb, GI, Whisstock, JC, Zhu, L   +17 more
core   +2 more sources

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source

Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma

OncoImmunology, 2018
Pediatric medulloblastomas are the most frequently diagnosed embryonal tumors of the central nervous system. Current therapies cause severe neurological and cognitive side effects including secondary malignancies.
Jeroen F. Vermeulen, Wim Van Hecke, Elisabeth J. M. Adriaansen, Mieke K. Jansen, Rianne G. Bouma, José Villacorta Hidalgo, Paul Fisch, Roel Broekhuizen, Wim G. M. Spliet, Marcel Kool, Niels Bovenschen   +10 more
doaj   +1 more source

A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome

Journal of Biological Chemistry, 2017
Enduring host-microbiome relationships are based on adaptive strategies within a particular ecological niche. Tannerella forsythia is a dysbiotic member of the human oral microbiome that inhabits periodontal pockets and contributes to chronic ...
T. Goulas, M. Ksiazek, I. Garcia-Ferrer, Alicja M. Sochaj-Gregorczyk, Irena Waligórska, M. Wasylewski, J. Potempa, F. Gomis-Rüth   +7 more
semanticscholar   +1 more source

Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition [PDF]

, 2014
Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum.
Budrikis, Z., Costantini, G., La Porta, C. A., Zapperi, S.   +3 more
core   +3 more sources

The Alpha‐1 Pi*MZ Genotype Is an Independent Risk Factor for Hepatocellular Carcinoma Development in Patients With ACLD

Alimentary Pharmacology &Therapeutics, EarlyView.
Alpha‐1 antitrypsin deficiency is a genetic disease that affects the lungs and the liver. The role of the heterozygous genetic defect in the development of liver cancer in patients with cirrhosis is unclear. Our study found that carrying the Pi*MZ genotype increases the risk of developing liver cancer.
Lorenz Balcar, Georg Semmler, Bernhard Scheiner, Rafael Paternostro, Benedikt Simbrunner, Tina Jasmin Haunold, Mathias Jachs, Lukas Hartl, Benedikt Silvester Hofer, Nina Dominik, Michael Schwarz, Georg Kramer, Christian Sebesta, Paul Thöne, Matthias Pinter, Michael Trauner, Thomas Reiberger, Albert Friedrich Stättermayer, Mattias Mandorfer   +18 more
wiley   +1 more source

Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells. [PDF]

, 2015
Many therapies using mesenchymal stem cells (MSC) rely on their ability to produce and release paracrine signals with chemotactic and pro-angiogenic activity.
Beegle, Julie R, Chávez, Myra N, Egaña, José T, Fierro, Fernando A, Isseroff, Roslyn R, O'Neal, Adam J, Peavy, Thomas R   +6 more
core   +2 more sources

A high‐throughput bone marrow 3D co‐culture system to study resistance to BCR signalling targeted agents in B‐NHL

British Journal of Haematology, EarlyView.
Bone marrow (BM) involvement in B‐cell non‐Hodgkin lymphoma (B‐NHL) is associated with poor prognosis, as the BM microenvironment provides a protective niche that promotes therapeutic resistance. We developed a simplified, automated and high‐throughput 3D BM co‐culture model that faithfully reproduces key tumour–stroma interactions.
Alex Zadro, Alberto Arribas, Maria Vittoria Colombo, Eleonora Cannas, Filippo Spriano, Luciano Cascione, Afua Adjeiwaa Mensah, Federico Simonetta, Dalila Petta, Christian Candrian, Chiara Arrigoni, Francesco Bertoni, Matteo Moretti   +12 more
wiley   +1 more source

Vaspin identified as a DNA‐binding serpin with functional consequences for protease inhibition

The FEBS Journal, EarlyView.
Vaspin is a serpin that is expressed in skin, adipose tissue, and liver. It binds to single‐ and double‐stranded DNA with high affinity. This binding is unaffected by mutation of the known heparin‐binding site, accelerates the inhibition of the inflammatory protease KLK7, and may contribute to vaspin's nuclear localization.
Kevin Möhlis, Abibe Useini, Heike Betat, Sonja Bonin, Helen Broghammer, Rima Nuwayhid, Stefan Langer, Mario Mörl, Norbert Sträter, John T. Heiker   +9 more
wiley   +1 more source

A Venom Serpin Splicing Isoform of the Endoparasitoid Wasp Pteromalus puparum Suppresses Host Prophenoloxidase Cascade by Forming Complexes with Host Hemolymph Proteinases*

Journal of Biological Chemistry, 2016
To ensure successful parasitism, parasitoid wasps inject venom along with their eggs into their hosts. The venom serves to suppress host immune responses, including melanization.
Zhichao Yan, Qi Fang, Yang Liu, Shan Xiao, Lei Yang, Fei Wang, C. An, J. Werren, G. Yè   +8 more
semanticscholar   +1 more source