Results 111 to 120 of about 24,818 (268)

Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis

Cell & Bioscience
Background Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors secreted by Trichinella spiralis play
Ruixue Li, Bing Zhang, Chen Chen
doaj   +1 more source

Characterization of Serpin Family Genes in Three Rice Planthopper Species and Their Expression Profiles in Response to Metarhizium Infection

Agronomy
Rice planthoppers, including Nilaparvata lugens, Sogatella furcifera, and Laodelphax striatellus, are major agricultural pests. Serpins, which function as serine protease inhibitors, play a pivotal role in the immune systems of these insects, especially ...
Ruonan Zhang, Zichun Zhong, Liyan He, Hongxin Wu, Liuyan He, Yujing Guo, Haoming Wu, Xiaoxia Xu, Fengliang Jin, Rui Pang   +9 more
doaj   +1 more source

Comparative Proteomics of Salinity Stress Responses in Fish and Aquatic Invertebrates

PROTEOMICS, EarlyView.
ABSTRACT Fluctuating salinity is symptomatic of climate change challenging aquatic species. The melting of polar ice, rising sea levels, coastal surface and groundwater salinization, and increased evaporation in arid habitats alter salinity worldwide. Moreover, the frequency and intensity of extreme weather events such as rainstorms and floods increase,
Maxime Leprêtre, Jens Hamar, Monica B. Urias, Dietmar Kültz   +3 more
wiley   +1 more source

Smoothing a rugged protein folding landscape by sequence-based redesign [PDF]

, 2016
The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance between function and misfolding.
Borg, NA, Bottomley, SP, Buckle, AM, Costa, MGS, Dai, W, Hoke, DE, Hollins, JJ, Irving, JA, Kass, I, Keleher, S, Marijanovic, EM, McGowan, S, Nickson, AA, Pearce, MA, Porebski, BT, Webb, GI, Whisstock, JC, Zhu, L   +17 more
core   +2 more sources

P53 and anti‐p53 autoantibody complex versus anti‐p53 antibody as a biomarker for gastrointestinal cancer

Precision Medical Sciences, EarlyView.
This study compares the diagnostic value of the anti‐p53 autoantibody as potential biomarkers for gastrointestinal cancer with enzyme‐linked immunosorbent assay technique. Abstract Gastrointestinal tract cancer is among the most common types of cancer and includes colorectal cancer (CRC) and gastric cancer (GC).
V. Hamidi Sofiani, A. Ebrahimian Shiadeh, A. Tabarraei, H. Razavi Nikoo, F. Sadeghi, Gh. Kamrani, Y. Yahyapour, A. Moradi   +7 more
wiley   +1 more source

SERPINs—From Trap to Treatment [PDF]

Frontiers in Medicine, 2019
Excessive enzyme activity often has pathological consequences. This for example is the case in thrombosis and hereditary angioedema, where serine proteases of the coagulation system and kallikrein-kinin system are excessively active. Serine proteases are controlled by SERPINs (serine protease inhibitors).
Sanrattana, Wariya, Maas, Coen, de Maat, Steven   +2 more
openaire   +5 more sources

Plasma POSTN Derived From Bile Proteome Is a Promising Biomarker for Cholangiocarcinoma With Efficacy Comparable and Complementary to CA19.9

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n 
Lichieh Julie Chu, Chia‐Jung Tsai, Chun‐Chun Chien, Yung‐Chin Hsiao, Jau‐Song Yu, Jun‐Yi Tsai, Ta‐Sen Yeh   +6 more
wiley   +1 more source

Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells. [PDF]

, 2015
Many therapies using mesenchymal stem cells (MSC) rely on their ability to produce and release paracrine signals with chemotactic and pro-angiogenic activity.
Beegle, Julie R, Chávez, Myra N, Egaña, José T, Fierro, Fernando A, Isseroff, Roslyn R, O'Neal, Adam J, Peavy, Thomas R   +6 more
core   +2 more sources

Thrombin inhibition by the serpins [PDF]

Journal of Thrombosis and Haemostasis, 2013
Thrombin is the central protease in the blood coagulation network. It has multiple substrates and cofactors, and it appears that four serpins are responsible for inhibiting the thrombin produced in haemostasis and thrombosis. Structural studies conducted over the last 10 years have resolved how thrombin recognises these serpins with the aid of ...
openaire   +3 more sources

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss [PDF]

, 2016
Background: A hypothesis exists whereby an exercise- or dietary-induced negative energy balance reduces human subcutaneous white adipose tissue (scWAT) mass through the formation of brown-like adipocyte (brite) cells.
Andrea R Josse, Asif Nakhuda, Björntorp, Chamorro-García, Collins, Crawford, Cypess, de Jong, Després, Digby, Donzelli, Ellero-Simatos, Frederic Raymond, Gburcik, Gburcik, Hannah Crossland, Holmström, James A Timmons, Jespersen, Josse, Josse, Krämer, Kusu, Lee, Liam Good, Lind, Moulin, Nissen, Petrovic, Petrovic, Philip J Atherton, Seale, Seale, Shan, Sood, Stanford, Stanford, Stenson, Stuart M Phillips, Sylviane Metairon, Timmons, Timmons, Timmons, Timmons, Toseland, Valentina Gburcik, Waldén, Wang, Wu   +48 more
core   +2 more sources