Therapeutic SERPINs: Improving on Nature [PDF]
Frontiers in Cardiovascular Medicine, 2021 Serine proteases drive important physiological processes such as coagulation, fibrinolysis, inflammation and angiogenesis. These proteases are controlled by serine protease inhibitors (SERPINs) that neutralize their activity.
Coen Maas, Steven de Maat
doaj +5 more sources
Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins. [PDF]
PLoS ONE, 2023 Serine protease inhibitors (serpins) include thousands of structurally conserved proteins playing key roles in many organisms. Mutations affecting serpins may disturb their conformation, leading to inactive forms.
Pedro Garrido-Rodríguez +8 more
doaj +3 more sources
“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions
Frontiers in Cardiovascular Medicine, 2023 The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a dynamic conformational change to trap and inhibit their target enzymes.
Steven J. Humphreys +2 more
doaj +2 more sources
Parasitoid Serpins Evolve Novel Functions to Manipulate Host Homeostasis. [PDF]
Mol Biol Evol, 2023 Parasitoids introduce various virulence factors when parasitism occurs, and some taxa generate teratocytes to manipulate the host immune system and metabolic homeostasis for the survival and development of their progeny.
Wu Z +9 more
europepmc +2 more sources
Serpins in Tick Physiology and Tick-Host Interaction
Frontiers in Cellular and Infection Microbiology, 2022 Tick saliva has been extensively studied in the context of tick-host interactions because it is involved in host homeostasis modulation and microbial pathogen transmission to the host.
Muhammad Nadeem Abbas +6 more
doaj +2 more sources
Plant Serpins: Potential Inhibitors of Serine and Cysteine Proteases with Multiple Functions [PDF]
Plants, 2023 Plant serpins are a superfamily of protein inhibitors that have been continuously studied in different species and have great biotechnological potential.
Monaliza Macêdo Ferreira +4 more
doaj +2 more sources
Bayesian phylogeny analysis of vertebrate serpins illustrates evolutionary conservation of the intron and indels based six groups classification system from lampreys for ∼500 MY [PDF]
PeerJ, 2015 The serpin superfamily is characterized by proteins that fold into a conserved tertiary structure and exploits a sophisticated and irreversible suicide-mechanism of inhibition.
Abhishek Kumar
doaj +3 more sources
Unveiling the levels and significance of different serpin family proteins in aqueous humor dynamics [PDF]
BMC OphthalmologyBackground Alterations in the constituents of the aqueous humor (AH) are associated with various ocular pathologies, including primary open-angle glaucoma (POAG).
Eliza Williams +11 more
doaj +2 more sources
Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis
Frontiers in Cardiovascular Medicine, 2022 Appropriate activation of coagulation requires a balance between procoagulant and anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis.
Steven P. Grover, Nigel Mackman
doaj +2 more sources
Viral SERPINS—A Family of Highly Potent Immune-Modulating Therapeutic Proteins [PDF]
Biomolecules, 2023 Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate serine proteases in the central coagulation and immune pathways, representing 2–10% of circulating proteins in the blood.
Kyle Varkoly +5 more
doaj +2 more sources