Results 11 to 20 of about 14,423 (252)

SERPINs—From Trap to Treatment [PDF]

open access: yesFrontiers in Medicine, 2019
Excessive enzyme activity often has pathological consequences. This for example is the case in thrombosis and hereditary angioedema, where serine proteases of the coagulation system and kallikrein-kinin system are excessively active. Serine proteases are
Wariya Sanrattana   +2 more
doaj   +6 more sources

Regulation of epidermal barrier function and pathogenesis of psoriasis by serine protease inhibitors [PDF]

open access: yesFrontiers in Immunology
Serine protease inhibitors (Serpins) are a protein superfamily of protease inhibitors that are thought to play a role in the regulation of inflammation, immunity, tumorigenesis, coagulation, blood pressure and cancer metastasis.
Juanjuan Wang   +9 more
doaj   +2 more sources

Serpins: Genome-Wide Characterisation and Expression Analysis of the Serine Protease Inhibitor Family in Triticum aestivum

open access: yesG3: Genes, Genomes, Genetics, 2019
The serine protease inhibitor (serpin) gene family is the largest family of protease inhibitors. Serine protease inhibitors have an active, but under-characterized, role in grain development and defense against pathogen attack in cereal crops.
Harriet R. Benbow   +2 more
doaj   +2 more sources

Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini [PDF]

open access: yesPathogens
Serine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang   +3 more
doaj   +2 more sources

Fasciola hepatica serine protease inhibitor family (serpins): Purposely crafted for regulating host proteases.

open access: yesPLoS Neglected Tropical Diseases, 2020
Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica excretory-secretory products indicates
Carolina De Marco Verissimo   +6 more
doaj   +2 more sources

Comparison of structures and inhibition activities of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis [PDF]

open access: yesCell & Bioscience
Background Trichinosis is one of the most widespread parasitic infections worldwide. Trichinella spiralis not only infects humans but can also utilize wild anddomestic animals as hosts. The serine protease inhibitors secreted by Trichinella spiralis play
Ruixue Li, Bing Zhang, Chen Chen
doaj   +2 more sources

Serpins in rice: protein sequence analysis, phylogeny and gene expression during development

open access: yesBMC Genomics, 2012
Background Most members of the serpin family of proteins are potent, irreversible inhibitors of specific serine or cysteine proteinases. Inhibitory serpins are distinguished from members of other families of proteinase inhibitors by their metastable ...
Francis Sheila E   +4 more
doaj   +2 more sources

Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

open access: yesFrontiers in Cellular and Infection Microbiology, 2017
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař   +5 more
doaj   +2 more sources

Cytosolic serpins act in a cytoprotective feedback loop that limits ESX-1-dependent death of Mycobacterium marinum-infected macrophages [PDF]

open access: yesmBio
Serine protease inhibitors (serpins) constitute the largest family of protease inhibitors expressed in humans, but their role in infection remains largely unexplored.
Esther Nobs   +5 more
doaj   +2 more sources

Serpins in arthropod biology. [PDF]

open access: yesSeminars in Cell & Developmental Biology, 2017
Serpins are the largest known family of serine proteinase inhibitors and perform a variety of physiological functions in arthropods. Herein, we review the field of serpins in arthropod biology, providing an overview of current knowledge and topics of interest.
D. Meekins, M. Kanost, K. Michel
semanticscholar   +4 more sources

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