Results 21 to 30 of about 14,423 (252)
Serpins in the Caenorhabditis elegans genome [PDF]
Proteins: Structure, Function, and Genetics, 1999 Data mining in genome sequences can identify distant homologues of known protein families, and is most powerful if solved structures are available to reveal the three-dimensional implications of very dissimilar sequences. Here we describe putative serpin sequences identified with very high statistical significance in the Caenorhabditis elegans genome ...
James C. Whisstock +4 more
openalex +5 more sources
Serine protease inhibitors and human wellbeing interplay: new insights for old friends [PDF]
PeerJ, 2019 Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets.
Héla Mkaouar +8 more
doaj +2 more sources
Serpins in cartilage and osteoarthritis: what do we know?
Biochemical Society Transactions, 2021 Serpins (serine proteinase inhibitors) are an ancient superfamily of structurally similar proteins, the majority of which use an elegant suicide inhibition mechanism to target serine proteinases. Despite likely evolving from a single common ancestor, the
David J. Wilkinson
semanticscholar +1 more source
Molecular Biology and Evolution, 2002 Members of the serpin (serine proteinase inhibitor) superfamily have been identified in higher multicellular eukaryotes (plants and animals) and viruses but not in bacteria, archaea, or fungi. Thus, the ancestral serpin and the origin of the serpin inhibitory mechanism remain obscure.
James A. Irving +5 more
openaire +3 more sources
Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders
Frontiers in Cardiovascular Medicine, 2021 Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential
Elsa P. Bianchini +4 more
semanticscholar +1 more source
Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms
Frontiers in Cardiovascular Medicine, 2021 The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine protease cascades are critical determinants of morbidity and mortality during infection and with vascular or tissue injury. Both the clot forming (thrombotic) and the
Jordan R. Yaron +4 more
semanticscholar +1 more source
Serpin functions in host-pathogen interactions [PDF]
PeerJ, 2018 Serpins are a broadly distributed superfamily of protease inhibitors that are present in all kingdoms of life. The acronym, serpin, is derived from their function as potent serine proteases inhibitors.
Jialing Bao +5 more
doaj +2 more sources
A reactive center loop–based prediction platform to enhance the design of therapeutic SERPINs
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Serine protease inhibitors (SERPINs) regulate vital physiological processes. Considerable research effort has gone into the development of SERPINs as therapeutic agents.
W. Sanrattana +7 more
semanticscholar +1 more source
Necrosis and the Serpin Under't [PDF]
Developmental Cell, 2007 Caspase proteases play essential roles in apoptotic cell death, while other proteases are active in necrotic cell death. In a recent paper in Cell, Luke et al. (2007) present findings demonstrating that a gene believed to be a natural protease inhibitor may have a role in preventing necrosis.
Mary C. Abraham, Shai Shaham
openaire +3 more sources
Serpins: the uncut version [PDF]
Structure, 1994 The structure of active antithrombin, the first active serpin to be solved, sheds new light on the conformational forms of this important class of inhibitor.
James Mottonen, Elizabeth J. Goldsmith
openaire +3 more sources